Multicenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical Center

多中心骨关节炎研究 (MOST) 第二次更新：爱荷华临床中心

• 批准号: 10227334
• 负责人: Neil A Segal
• 金额: $ 6.08万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10227334
• 关键词: 3-Dimensional; Acute; Address; Affect; Age; Aging; Animal Model; Arthritis; Biomechanics; Bone Density; Calcium; Cartilage; Chronic; Cohort Studies; Crystallization; Degenerative polyarthritis; Deposition; Deterioration; Development; Disease; Elderly; Environment; Evaluation; Frequencies; Gait; Goals; Heel; Hip region structure; Inflammation; Iowa; Joints; Knee; Knee Osteoarthritis; Knee joint; Knowledge; Lead; Longitudinal cohort study; Lower Extremity; Magnetic Resonance Imaging; Measures; Meniscus structure of joint; Muscle Weakness; Musculoskeletal; Outcome; Pain; Pain management; Persons; Prevention; Prevention strategy; Risk; Risk Factors; Sensory; Severities; Source; Structure; Symptoms; Techniques; Testing; Time; Walking; base; bone; chronic pain; clinical center; cohort; comorbidity; conditioned pain modulation; disability; disorder prevention; experience; falls; functional loss; high risk; insight; joint injury; knee pain; loss of function; member; new technology; novel; osteoarthritis pain; pain outcome; pain sensitivity; persistent symptom; prevent; recruit

PROJECT SUMMARY Knee osteoarthritis (OA) is a common chronic painful disorder that is the most frequent cause of mobility disability in older people. The MOST study has been a major source of new knowledge about the course of this disease and factors that affect its course. Since the study began in 2003, it is increasingly recognized that by the time people develop chronic symptoms of knee OA, they usually have advanced structural findings of disease on MRI. Findings such as meniscal tears, malalignment and cartilage loss drive further structural deterioration and almost certainly limit prevention opportunities. We believe that prevention opportunities are likely to be greater if started in those who do not yet have severe continuous knee pain or advanced structural findings of disease. The functional impacts of knee OA occur in older people who experience multiple musculoskeletal comorbidities, and preventing disablement from OA requires a broader perspective than a focus on a single knee. For example, those with pain in one knee are at high risk of pain in other lower extremity musculoskeletal regions and, even if the knee is replaced, they may ultimately need treatment for pain in other joints developing as a consequence of the first joint affected. Also, in addition to functional loss, persons with OA experience buckling, falls and constraints in their involvement with the outside environment. We suggest there are opportunities to develop treatments and disease prevention strategies that have been unexplored and that by using new technologies and focusing on persons at a milder or earlier disease stage than previous studies, we can identify such opportunities. We propose to recruit a new mild disease cohort and continue to study the existing MOST cohort to identify new risk factors for disease and to study consequences of disease. Our goal is to find new strategies to prevent disease at an early stage and to limit the impact of disease once it has occurred.

项目摘要 膝关节骨关节炎（OA）是一种常见的慢性疼痛性疾病，是最常见的原因，流动性 老年人的残疾。MOST研究一直是有关这一过程的新知识的主要来源 疾病及其影响因素。自2003年开始研究以来，人们越来越认识到， 当人们出现膝关节OA的慢性症状时，他们通常有先进的结构发现， MRI上的疾病诸如椎间盘撕裂、对线不良和软骨损失等发现进一步推动了结构性疾病的发生。 恶化，几乎肯定会限制预防的机会。我们认为，预防机会是 如果在那些还没有严重的持续性膝关节疼痛或先进的结构性疼痛的人中开始， 疾病的发现。 膝关节OA的功能影响发生在经历多种肌肉骨骼疾病的老年人中。 合并症，预防OA致残需要更广泛的视角，而不是专注于单一的 膝盖例如，那些在一个膝盖疼痛是在其他下肢肌肉骨骼疼痛的高风险 即使膝关节被替换，他们最终也可能需要治疗其他关节的疼痛， 因为第一个关节受影响。此外，除了功能丧失外，有OA经验的人 屈曲、福尔斯和它们与外部环境接触时的约束。 我们建议有机会开发治疗和疾病预防策略， 通过使用新技术和侧重于处于较轻或较早疾病阶段的人 比以前的研究，我们可以确定这样的机会。我们建议招募一个新的轻度疾病队列， 继续研究现有的MOST队列，以确定新的疾病风险因素并研究其后果 疾病。我们的目标是找到新的策略，在早期阶段预防疾病，并限制 疾病一旦发生。

项目成果

Clinical value of weight-bearing CT and radiographs for detecting patellofemoral cartilage visualized by MRI in the MOST study.

• DOI: 10.1016/j.joca.2021.07.011
• 发表时间: 2021-11
• 期刊: Osteoarthritis and cartilage
• 影响因子: 7
• 作者: Segal NA;Murphy MT;Everist BM;Brown KD;He J;Lynch JA;Nevitt MC
• 通讯作者: Nevitt MC

Quantitative Three-dimensional Assessment of Knee Joint Space Width from Weight-bearing CT.

• DOI: 10.1148/radiol.2021203928
• 发表时间: 2021-06
• 期刊: Radiology
• 影响因子: 19.7

Multiparametric 3-D analysis of bone and joint space width at the knee from weight bearing computed tomography.

通过承重计算机断层扫描对膝盖骨和关节间隙宽度进行多参数 3-D 分析。

• DOI: 10.1016/j.ostima.2022.100069
• 发表时间: 2022
• 期刊: Osteoarthritis imaging
• 作者: Turmezei,TomD;Low,SamanthaB;Rupret,Simon;Treece,GrahamM;Gee,AndrewH;MacKay,JamesW;Lynch,JohnA;Poole,KennethEs;Segal,NeilA
• 通讯作者: Segal,NeilA