权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Impacts of sarcomeric protein phosphorylation on ischemic hearts

肌节蛋白磷酸化对缺血心脏的影响

基本信息

批准号：
10225539
负责人：
Yuejin Li
金额：
$ 15.1万
依托单位：
MORGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10225539
关键词：
Actomyosin Adenosinetriphosphatase Address Adenovirus Vector Adult Affect Amino Acids Biological Markers Blood C-terminal Calpain Cardiac Cardiac Muscle Contraction Cardiac Myocytes Cardiac Surgery procedures Cessation of life Consumption Coronary heart disease Data Development Disease Energy Metabolism Functional disorder Genetic Goals Healthcare Heart Heart Diseases Heart failure Historically Black Colleges and Universities Human In Vitro Injury Ischemia Knowledge Measures Mechanics Modification Molecular Molecular Conformation Molecular Motors Mus Muscle Muscle Contraction Mutation Myocardial Myocardial Infarction Myocardial Ischemia Myocardial dysfunction Myocardium Nutrient Oxidative Stress Oxygen Pathologic Patients Peptide Hydrolases Periodicity Phosphorylation Physiological Physiology Play Principal Investigator Proteins Proteolysis Publishing Pump Rattus Recombinant Proteins Recovery of Function Regulation Reperfusion Injury Reperfusion Therapy Reporting Research Research Project Grants Role Silent Mutation Site Stress Survivors System Testing Transgenic Mice Transgenic Organisms Troponin I United States United States National Institutes of Health Universities Vascular blood supply Western Blotting antioxidant enzyme cardiac muscle disease cardioprotection effective therapy enzyme activity experience familial dilated cardiomyopathy heart function improved interest member mimetics mouse model myocardial injury novel novel therapeutic intervention phosphoproteomics prevent programs response

项目摘要

PROJECT SUMMARY Each year in the U.S., approximately 2 million people experienced myocardial ischemia (inadequate blood supply to heart muscle). Ischemic heart disease is a common cause of heart failure. Currently, about 1.6 million post-ischemia survivors live with ischemic heart failure, a deadly condition without effective treatment. The main function of the heart is to pump out blood to supply the body with nutrients and oxygen. Sarcomeric proteins make up the molecular motor of the heart muscle, which are essential for heart function. Modifications on sarcomeric proteins play a central role in regulating heart function in various physiological and diseased conditions. The long-term goal of our lab is to understand how modifications on sarcomeric proteins affect heart function in ischemia and the consequent ischemic heart failure. The effort will lead to potential new therapeutic strategies or biomarkers for the deadly heart diseases. The present proposal focuses on one of the key sarcomeric protein regulators, called cardiac troponin I (cTnI). Recently, we have found that its modifications are significantly altered in the patients with ischemic heart failure as well as the heart failure resulting from genetic heart muscle diseases. The preliminary study has shown that one crucial cTnI modification site protects heart from ischemia-related injury and is kept at a high level of modification in the consequent ischemic heart failure. The proposed study will address the question: how the cTnI modification protects heart function from ischemia-related injury. There are two specific aims: 1) to investigate the molecular and cellular cardioprotective mechanism conveyed by the cTnI modification; 2) to test whether the protective function is unique to the proposed site. The proposed project has broad impacts; it will not only produce knowledge about heart function regulation and ischemic heart disease but also help the principal investigator build strong research program at Morgan State University, a prestigious member of Historically Black Colleges and Universities, in order to promote the workforce diversity in biomedical field and health care.

项目总结