Mechanisms that underlie poorer binaural outcomes in patients with asymmetrical hearing and bilateral cochlear implants

听力不对称且双侧人工耳蜗植入患者双耳结果较差的机制

• 批准号: 10226859
• 负责人: SEAN R ANDERSON
• 金额: $ 3.12万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2022-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10226859
• 关键词: Acoustic Nerve; Adult; Affect; Age; Aging; Algorithms; Auditory system; Bilateral; Binaural; Brain Stem; Cell model; Cochlear Implants; Cochlear nucleus; Cognition; Collaborations; Communities; Computer Models; Computer software; Cues; Deterioration; Development; Disease; Ear; Electrophysiology (science); Exhibits; Frequencies; Future; Goals; Hearing; Hearing Aids; Implanted Electrodes; Knowledge; Laboratories; Lead; Light; Literature; Measures; Modeling; Nerve Fibers; Neurons; Noise; Outcome; Participant; Pathway interactions; Patient Self-Report; Patient-Focused Outcomes; Patients; Perception; Performance; Physiological; Physiology; Psychophysics; Reporting; Research; Scientist; Side; Sound Localization; Speech; Speech Perception; Stimulus; Testing; Training Programs; age effect; binaural hearing; career; computerized tools; design; experimental study; hearing impairment; improved; improved outcome; neural model; normal hearing; novel; preference; response; simulation; skills; sound; speech in noise; temporal measurement

PROJECT SUMMARY/ABSTRACT Binaural hearing allows listeners to better understand speech in noise and localize sounds. This proposal aims to develop a clearer understanding of the mechanisms that contribute to poorer binaural hearing abilities in patients with cochlear implants. The proposed experiments investigate the effects of poor hearing outcomes in one or both ears on speech perception and computational modeling of binaural processing in the brainstem. Abnormal speech perception with poor speech outcomes in one or both ears may contribute to poorer speech understanding in noise. Aim 1 will investigate differences in speech perception in cases of simulated or actual asymmetrical hearing, when speech understanding is poor in one or both ears. Factors that affect cochlear implant patients, namely the fidelity of temporal information conveyed by cochlear implant electrodes, will be simulated in younger and older listeners with normal hearing to account for aging effects. By testing participants with normal hearing and cochlear implants, results will have important implications for changes in perception with disease and perception with normal hearing. Poor encoding of binaural cues with asymmetrical hearing may result in reduced sensitivity to binaural cues and poorer sound localization performance. Aim 2 will develop a computational model of binaural encoding in the brainstem where one or both sides are deteriorated as in hearing impairment to predict the effects of hearing loss and cochlear implant stimulation on binaural processing. This approach will allow for an explanation of perceptual results in terms of the physiological mechanisms involved in the brainstem. Specific factors that affect patients with hearing loss and patients that use cochlear implants can be modeled and assessed separately to account for changes that occur along the binaural pathway. The training program will result in the development of the following specific scientific skills: (1) sound processing for cochlear implant simulations and speech perception experiments, (2) programming cochlear implants for direct connect experiments, (3) development and testing of computational models of binaural processing, and (4) ability to make electrophysiological recordings and understand their limitations. Each of these skills is critical to the applicant’s development as a scientist and future career in binaural hearing research. With these and other existing research skills, it will be possible to establish an independent and productive line of research concerning binaural hearing outcomes for adults with bilateral cochlear implants and normal hearing. Good binaural hearing improves the lives of patients. The results of the projects in this proposal will shed light on the perceptual and physiological problems that limit binaural hearing abilities in listeners with bilateral cochlear implants. Ultimately, these results will be important in understanding the limitations to binaural hearing for cochlear implants and improved cochlear implant processing strategies.

项目总结/摘要 双耳听力允许听众在噪音中更好地理解语音并定位声音。这项建议 旨在更清楚地了解导致双耳听力下降的机制 植入人工耳蜗的病人拟议的实验调查了听力不佳的影响 在一只或两只耳朵中进行语音感知和脑干双耳处理的计算建模。 异常的言语知觉与一只或两只耳朵的言语结果差可能导致更差的 噪声中的语音理解目的1将调查在模拟或模拟的情况下言语感知的差异。 实际上不对称的听力，当一只或两只耳朵的言语理解能力很差时。影响耳蜗的因素 植入患者，即由耳蜗植入电极传达的时间信息的保真度， 在具有正常听力的年轻和老年听众中模拟，以说明老化效应。通过测试参与者 在听力正常和人工耳蜗植入的情况下，结果将对感知的变化产生重要影响。 有疾病和正常听力的感知。 不对称听力的双耳线索编码不良可能会导致对双耳信号的敏感性降低。 线索和较差的声音定位性能。目标2将开发一个双耳编码的计算模型 在脑干中，一侧或两侧都恶化，如听力受损，以预测 听力损失和人工耳蜗刺激对双耳处理的影响。这种方法可以解释 从脑干的生理机制来看，的具体因素 影响听力损失患者和使用人工耳蜗植入物的患者可以建模和评估 以解释沿着双耳通路发生的变化。 培训计划将导致以下具体科学技能的发展：（1）声音 人工耳蜗植入模拟和语音感知实验的处理，（2）编程人工耳蜗 用于直接连接实验的植入物，（3）开发和测试双耳的计算模型， 处理，和（4）进行电生理记录和了解其局限性的能力。这一切成功都 技能是申请人的发展，作为一个科学家和未来的职业生涯在双耳听力研究的关键。与 这些和其他现有的研究技能，将有可能建立一个独立的和生产线， 关于双侧人工耳蜗植入和听力正常成人双耳听力结果的研究。 良好的双耳听力改善了患者的生活。本提案中的项目成果将 光的知觉和生理问题，限制双耳听力能力的听众与双边 人工耳蜗最终，这些结果将是重要的了解限制双耳听力 用于耳蜗植入物和改进的耳蜗植入物处理策略。