STI Response and Recommendations Under PrEP (STIRRUP)

PrEP (STIRRUP) 下的性传播感染应对和建议

基本信息

  • 批准号:
    10402695
  • 负责人:
  • 金额:
    $ 63.32万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-02-01 至 2026-12-31
  • 项目状态:
    未结题

项目摘要

ABSTRACT STIRRUP (STI Responses and Recommendations Under PrEP) combines big data streams with mathemat- ical modeling and economic decision science to understand the optimal design of STI screening in PrEP care. Cases of gonorrhea, chlamydia, and syphilis have increased substantially over the past decade and a dispro- portionate disease burden falls on men who have sex with men (MSM). The persistently high STI rates among MSM are driven by the high proportion of asymptomatic infections and low rates of routine screening that would detect these infections. Most MSM who use PrEP are at elevated risk of acquiring STIs. PrEP care therefore provides a critical opportunity to reach and clinically engage a population who could benefit from linked HIV and STI prevention services. Screening for STIs in PrEP care following CDC recommendations can counterbalance the effects of increases in sexual risk behavior by treating asymptomatic STIs to prevent ongo- ing STI transmission chains. However, patterns of STI screening in PrEP care are far from recommended levels, with substantial variation by demographics and geography. Models informing clinical practice and public health policy must therefore incorporate data streams that span the range of healthcare settings where PrEP care is offered to these groups, and where it can be improved. Following an Extended, Multi-Disease PrEP Continuum of Care that includes steps for STI ancillary services and PrEP retention, we seek to test a leading hypothesis about the bidirectionality of these two steps: that ongoing comprehensive PrEP care is an efficient mechanism for routine STI screening and treatment, but that frequent STI ancillary services may often be a burden to retention in PrEP care. STIRRUP includes three SPECIFIC AIMS: AIM 1. We will extract, collect, analyze, and synthesize information on PrEP care, sexual behavior, mental health diagnoses, and HIV/STI screening patterns for MSM from electronic health records and epidemiological studies in three types of PrEP programs (academic, public, and private) in two geographic settings (Boston and Atlanta) distinguished by their HIV/STI burden and demographics. Analyses will guide development of an ethical framework for big data in modeling. AIM 2. With these data, we will build network-based race-stratified transmission models of four co- circulating infections (HIV, chlamydia, syphilis, and gonorrhea) among MSM at three exposure sites (urogeni- tal, rectal, and pharyngeal). These models will investigate the relationship between PrEP use and HIV/STI incidence given current bacterial STI screening/treatment (pre- and post-PrEP initiation), with a theory-driven focus on racial/ethnic disparities and mental health predictors across and within each city. AIM 3. We will eval- uate public health policies and clinical practice strategies for screening and treatment of STIs among heterogenous groups of MSM using PrEP. Economic models will estimate the cost-effectiveness of policies individualized to clinical histories, and evaluate the optimal approach to targeting societal resources to reduce out-of-pocket user costs for ancillary PrEP services that could improve long-term PrEP retention.
摘要 STIRRUP(STI Responses and Recommendations Under PrEP)结合了大数据流和数据分析, 科学建模和经济决策科学,以了解PrEP护理中STI筛查的最佳设计。 淋病、衣原体和梅毒的病例在过去十年中大幅增加, 男性同性性行为者(MSM)承担了福尔斯的前列腺疾病负担。性传播感染率居高不下, 无症状感染的高比例和常规筛查的低比例是导致MSM的原因, 能检测出这些感染大多数使用PrEP的MSM患性病的风险都很高。PrEP护理 因此,提供了一个关键的机会,以达到和临床参与的人群谁可以受益于 将艾滋病毒和性传播感染预防服务联系起来。根据CDC的建议,在PrEP护理中筛查性传播感染可以 通过治疗无症状性传播感染来抵消性风险行为增加的影响, STI传播链。然而,在PrEP护理中进行STI筛查的模式远未得到推荐 人口统计学和地理学差异很大。为临床实践和公众提供信息的模型 因此,卫生政策必须纳入数据流,这些数据流涵盖了PrEP 向这些群体提供护理,并在哪些方面可以改进。在一个扩展的,多疾病的PrEP 连续护理包括STI辅助服务和PrEP保留的步骤,我们寻求测试领先的 关于这两个步骤的双向性的假设:正在进行的全面PrEP护理是一种有效的 常规性传播感染筛查和治疗的机制,但频繁的性传播感染辅助服务可能往往是 负担保留在PrEP护理. STIRRUP包括三个具体目标:目标1。我们会提取,收集, 分析和综合有关PrEP护理、性行为、心理健康诊断和艾滋病毒/性传播感染的信息 从电子健康记录和流行病学研究中筛查MSM的模式 计划(学术,公共和私人)在两个地理环境(波士顿和亚特兰大)区分他们的 艾滋病毒/性传播感染负担和人口统计。分析将指导大数据道德框架的制定, 建模AIM 2.有了这些数据,我们将建立基于网络的种族分层传输模型的四个合作, 男男性接触者在三个接触点(泌尿生殖道, 谈话、直肠和咽)。这些模型将调查PrEP使用与HIV/STI之间的关系 考虑到当前细菌性STI筛查/治疗(PrEP启动前后)的发生率, 重点关注每个城市之间和内部的种族/民族差异和心理健康预测因素。AIM 3.我们会评估- 评估公共卫生政策和临床实践战略,以筛查和治疗 经济模型将估计政策的成本效益 个性化的临床病史,并评估最佳方法,以针对社会资源,以减少 辅助PrEP服务的自付用户成本,可以改善PrEP的长期保留。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Samuel Jenness其他文献

Samuel Jenness的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Samuel Jenness', 18)}}的其他基金

STI Response and Recommendations Under PrEP (STIRRUP)
PrEP (STIRRUP) 下的性传播感染应对和建议
  • 批准号:
    10555335
  • 财政年份:
    2022
  • 资助金额:
    $ 63.32万
  • 项目类别:
EpiModel 2.0: Integrated Network Models for HIV/STI Prevention Science
EpiModel 2.0:HIV/STI 预防科学的综合网络模型
  • 批准号:
    10179311
  • 财政年份:
    2018
  • 资助金额:
    $ 63.32万
  • 项目类别:

相似海外基金

Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
  • 批准号:
    24K16488
  • 财政年份:
    2024
  • 资助金额:
    $ 63.32万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Mighty Accounting - Accountancy Automation for 1-person limited companies.
Mighty Accounting - 1 人有限公司的会计自动化。
  • 批准号:
    10100360
  • 财政年份:
    2024
  • 资助金额:
    $ 63.32万
  • 项目类别:
    Collaborative R&D
Accounting for the Fall of Silver? Western exchange banking practice, 1870-1910
白银下跌的原因是什么?
  • 批准号:
    24K04974
  • 财政年份:
    2024
  • 资助金额:
    $ 63.32万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
CPS: Medium: Making Every Drop Count: Accounting for Spatiotemporal Variability of Water Needs for Proactive Scheduling of Variable Rate Irrigation Systems
CPS:中:让每一滴水都发挥作用:考虑用水需求的时空变化,主动调度可变速率灌溉系统
  • 批准号:
    2312319
  • 财政年份:
    2023
  • 资助金额:
    $ 63.32万
  • 项目类别:
    Standard Grant
A New Direction in Accounting Education for IT Human Resources
IT人力资源会计教育的新方向
  • 批准号:
    23K01686
  • 财政年份:
    2023
  • 资助金额:
    $ 63.32万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
An empirical and theoretical study of the double-accounting system in 19th-century American and British public utility companies
19世纪美国和英国公用事业公司双重会计制度的实证和理论研究
  • 批准号:
    23K01692
  • 财政年份:
    2023
  • 资助金额:
    $ 63.32万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
An Empirical Analysis of the Value Effect: An Accounting Viewpoint
价值效应的实证分析:会计观点
  • 批准号:
    23K01695
  • 财政年份:
    2023
  • 资助金额:
    $ 63.32万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Accounting model for improving performance on the health and productivity management
提高健康和生产力管理绩效的会计模型
  • 批准号:
    23K01713
  • 财政年份:
    2023
  • 资助金额:
    $ 63.32万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
New Role of Not-for-Profit Entities and Their Accounting Standards to Be Unified
非营利实体的新角色及其会计准则将统一
  • 批准号:
    23K01715
  • 财政年份:
    2023
  • 资助金额:
    $ 63.32万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Improving Age- and Cause-Specific Under-Five Mortality Rates (ACSU5MR) by Systematically Accounting Measurement Errors to Inform Child Survival Decision Making in Low Income Countries
通过系统地核算测量误差来改善特定年龄和特定原因的五岁以下死亡率 (ACSU5MR),为低收入国家的儿童生存决策提供信息
  • 批准号:
    10585388
  • 财政年份:
    2023
  • 资助金额:
    $ 63.32万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了