Vaper to Vaper (V2V): A Multimodal Mobile Peer Driven Intervention to Support Adolescents in Quitting Vaping

7.项目总结/摘要 FDA和美国外科医生称，美国青少年越来越多地使用电子烟， 流行病，电子烟的使用超过了可燃香烟的使用。电子烟中尼古丁含量高 损害青少年大脑发育，影响学习、记忆和注意力。青少年电子烟使用者 也比非吸烟者更容易转向传统香烟。虽然预防很重要， 迫切需要采取循证干预措施，吸引和帮助青少年电子烟使用者戒烟。关键 挑战包括青少年认为使用电子烟的风险低，导致戒烟意愿低， 以及同龄人对电子烟使用的主要影响。鉴于目前没有证据表明 干预措施，以帮助青少年电子烟使用者戒烟，由美国科学院建议， 儿科和FDA，我们建议开发Vaper-to-Vaper（V2 V），一种多模式移动的同行驱动的干预， 根据我们以前烟草干预工作的经验教训。同行驱动的干预措施已被发现， 成功地改善了青少年吸烟的结果，我们已经成功地发展了同伴驱动的 低动机成年吸烟者的干预措施。因此，我们将调整这些方法为青少年e- 吸烟者。V2 V的目标将是参与，教育，激励和促进青少年使用策略 来控制自己的欲望并成功戒烟V2 V组件将包括：对等消息传递（定制消息 通过短信推送），同伴教练（通过短信与训练有素的教练进行异步交流），以及 游戏化（利用游戏设计来激励参与）。使这些工具适应以下方面的独特需求： 青少年电子烟使用者将进一步将这些工具扩展到新的方向。关于目标1，我们将召开一次 由20名青少年电子烟使用者组成的同行咨询小组参与定性评估，并进一步 开发V2 V组件。在目标2中，我们将评估研究方案的可行性， V2 V干预的可行性和可接受性在一项试点可行性研究与80青少年电子烟 从4所高中（学校随机分配到V2 V干预或对照组）招募用户并进行随访， 6个月我们假设能够招募80名青少年（20/学校，40/研究条件）， 在6个月随访时，每种研究条件下将保留>85%（目标2A）。对于目标2b，我们将监测V2 V 接合（例如，完成的V2 V短信测验次数、同伴指导互动次数、观看的同伴视频次数） 并评估该计划的可接受性和满意度。对于目标2C，我们假设干预 将与更大的可替宁验证的7天点患病率电子烟戒烟率相关， 第一次尝试戒烟，6个月随访时与对照组相比，电子烟使用量较少。这个阶段我 项目，调整现有的干预措施和可行性/试点测试，将提供必要的材料， 继续进行后续大规模III期R 01试验以测试V2 V干预的有效性 支持青少年电子烟使用者戒烟。

7. Project Summary/Abstract The FDA and the US Surgeon General call the increasing use of e-cigarettes among U.S. adolescents an epidemic, with e-cigarette use exceeding combustible cigarette use. The high amounts of nicotine in e-cigarettes harm adolescent brain development, impacting learning, memory, and attention. Adolescent e-cigarette users also are at higher risk than non-users of transitioning to traditional cigarettes. While prevention is important, evidence-based interventions to engage and help adolescent e-cigarette users quit are critically needed. Key challenges include adolescents perceiving e-cigarette use to be of low risk resulting in a low intention to quit, and the major influence of peers in e-cigarette use. Given there currently are no evidence-based cessation interventions to assist adolescent e-cigarette users in quitting, as suggested by the American Academy of Pediatrics and FDA, we propose to develop Vaper-to-Vaper (V2V), a multi-modal mobile peer driven intervention, based on lessons learned in our prior tobacco intervention work. Peer-driven interventions have been found to successfully improve smoking outcomes in adolescents, and we have had success in developing peer-driven interventions for low motivated adult smokers. We therefore will adapt these approaches for adolescent e- cigarette users. V2V’s goal will be to engage, educate, motivate, and facilitate the adolescent in using strategies to manage cravings and successfully quit. The V2V components will include: Peer Messaging (tailored messages pushed via texting), Peer Coaching (asynchronous communications with trained coaches via texting), and Gamification (using game design to motivate participation). Adapting these tools to the unique needs of adolescent e-cigarette users will further extend these tools into novel directions. For Aim 1 we will convene a peer advisory panel of 20 adolescent e-cigarette users to participate in a qualitative assessment and further development of V2V components. In Aim 2 we will evaluate the feasibility of the research protocols and the feasibility and acceptability of the V2V intervention in a pilot feasibility study with eighty adolescent e-cigarette users from 4 high schools (schools randomized to either V2V intervention or control) recruited and followed for 6 months. We hypothesize being able to recruit 80 adolescents (20/school, 40 per study condition) and that >85% will be retained in each study condition at 6-month follow-up (Aim 2A). For Aim 2b we will monitor V2V engagement (e.g., number of V2V texting quizzes completed, peer coaching interactions, peer videos viewed) and assess acceptability of and satisfaction with the program. For Aim 2C we hypothesize that the intervention will be associated with greater cotinine-validated 7-day point prevalence vaping abstinence rates, lower time to first quit attempt, and less amount of e-cigarette use compared to control at 6-month follow-up. This Stage I project, adapting an existing intervention and feasibility/pilot testing, will provide the necessary materials and information to proceed to a subsequent large-scale Stage III R01 trial to test the efficacy of the V2V intervention in supporting adolescent e-cigarette users in quitting.