Vaper to Vaper (V2V): A Multimodal Mobile Peer Driven Intervention to Support Adolescents in Quitting Vaping

7.项目摘要/摘要 FDA和美国卫生局局长称美国青少年和青少年中电子烟的使用增加 流行，电子烟的使用量超过可燃香烟的使用量。电子烟中尼古丁的含量很高 危害青少年大脑发育，影响学习、记忆和注意力。青少年电子烟使用者 与非吸烟者相比，他们也面临着更高的转向传统香烟的风险。虽然预防很重要， 迫切需要以证据为基础的干预措施，以参与并帮助青少年电子烟使用者戒烟。钥匙 挑战包括青少年认为使用电子烟的风险较低，因此戒烟意愿较低， 以及同龄人对电子烟使用的主要影响。鉴于目前还没有基于证据的戒烟方法 根据美国科学院的建议，采取干预措施帮助青少年电子烟使用者戒烟 儿科和FDA，我们建议开发Vaper-to-Vaper(V2V)，一种多模式移动同行驱动的干预， 根据我们以前的烟草干预工作中吸取的经验教训。同行驱动的干预已被发现 成功地改善了青少年的吸烟结果，我们在发展同伴驱动型方面也取得了成功 针对动机较低的成年吸烟者的干预。因此，我们将调整这些方法，以适应青少年的电子- 吸烟者。V2V的目标将是让青少年参与、教育、激励和促进他们使用策略 控制食欲并成功戒烟。V2V组件将包括：对等消息(定制消息 通过短信推送)，同行教练(通过短信与训练有素的教练进行异步交流)，以及 游戏化(使用游戏设计来激发参与度)。调整这些工具以满足 青少年电子烟用户将进一步将这些工具扩展到新的方向。对于目标1，我们将召开一次 由20名青少年电子烟使用者组成的同行咨询小组参与定性评估，并进一步 V2V组件的开发。在目标2中，我们将评估研究方案和 V2V干预在80例青少年电子烟试点可行性研究中的可行性和可接受性 来自4所高中的用户(学校随机分为V2V干预组或对照组)招募并跟踪调查 六个月。我们假设能够招募80名青少年(每所学校20名，每个研究条件40名)，并且 在6个月的随访中，在每个研究条件下将保留85%(目标2A)。对于AIM 2b，我们将监控V2V 参与度(例如，完成的V2V短信测验数量、同伴辅导互动、观看同伴视频) 并评估该计划的可接受性和满意度。对于目标2C，我们假设干预 将与更高的可替宁验证的7天点汽化戒断率相关，更短的时间 第一次戒烟尝试，在6个月的随访中，与对照组相比，电子烟的使用量更少。本阶段一 项目，适应现有的干预措施和可行性/试点测试，将提供必要的材料和 继续进行随后的大规模III R01阶段试验以测试V2V干预的有效性的信息 支持青少年电子烟使用者戒烟。

7. Project Summary/Abstract The FDA and the US Surgeon General call the increasing use of e-cigarettes among U.S. adolescents an epidemic, with e-cigarette use exceeding combustible cigarette use. The high amounts of nicotine in e-cigarettes harm adolescent brain development, impacting learning, memory, and attention. Adolescent e-cigarette users also are at higher risk than non-users of transitioning to traditional cigarettes. While prevention is important, evidence-based interventions to engage and help adolescent e-cigarette users quit are critically needed. Key challenges include adolescents perceiving e-cigarette use to be of low risk resulting in a low intention to quit, and the major influence of peers in e-cigarette use. Given there currently are no evidence-based cessation interventions to assist adolescent e-cigarette users in quitting, as suggested by the American Academy of Pediatrics and FDA, we propose to develop Vaper-to-Vaper (V2V), a multi-modal mobile peer driven intervention, based on lessons learned in our prior tobacco intervention work. Peer-driven interventions have been found to successfully improve smoking outcomes in adolescents, and we have had success in developing peer-driven interventions for low motivated adult smokers. We therefore will adapt these approaches for adolescent e- cigarette users. V2V’s goal will be to engage, educate, motivate, and facilitate the adolescent in using strategies to manage cravings and successfully quit. The V2V components will include: Peer Messaging (tailored messages pushed via texting), Peer Coaching (asynchronous communications with trained coaches via texting), and Gamification (using game design to motivate participation). Adapting these tools to the unique needs of adolescent e-cigarette users will further extend these tools into novel directions. For Aim 1 we will convene a peer advisory panel of 20 adolescent e-cigarette users to participate in a qualitative assessment and further development of V2V components. In Aim 2 we will evaluate the feasibility of the research protocols and the feasibility and acceptability of the V2V intervention in a pilot feasibility study with eighty adolescent e-cigarette users from 4 high schools (schools randomized to either V2V intervention or control) recruited and followed for 6 months. We hypothesize being able to recruit 80 adolescents (20/school, 40 per study condition) and that >85% will be retained in each study condition at 6-month follow-up (Aim 2A). For Aim 2b we will monitor V2V engagement (e.g., number of V2V texting quizzes completed, peer coaching interactions, peer videos viewed) and assess acceptability of and satisfaction with the program. For Aim 2C we hypothesize that the intervention will be associated with greater cotinine-validated 7-day point prevalence vaping abstinence rates, lower time to first quit attempt, and less amount of e-cigarette use compared to control at 6-month follow-up. This Stage I project, adapting an existing intervention and feasibility/pilot testing, will provide the necessary materials and information to proceed to a subsequent large-scale Stage III R01 trial to test the efficacy of the V2V intervention in supporting adolescent e-cigarette users in quitting.