Neural Mechanisms Underlying IC/BPS
Neural Mechanisms Underlying IC/BPS
批准号:
10401907
负责人:
Vijay K Samineni
金额:
$46.94万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-05-05 至 2026-02-28
关键词:
Absence of pain sensationAffectAnalgesicsBehavioralBladderBladder ControlBladder DiseasesBrain StemCellsChronicClinicalCystitisDevelopmentElectric StimulationElectrophysiology (science)EquilibriumEquipment and supply inventoriesEtiologyExhibitsFunctional disorderGeneticHypersensitivityInterstitial CystitisKnowledgeLeadLocal TherapyMaintenanceMolecularMorphineMusNeuraxisNeuronsNeurotransmittersNociceptionOpioidOutputPainPathologyPathway interactionsPelvic PainPeripheralPersistent painPharmaceutical PreparationsPharmacologyPopulationProcessPropertyRegulationResolutionRoleSliceSpinalSpinal CordStimulusSymptomsSynapsesSyndromeSystemTestingTherapeuticUnited StatesWomanWorkafferent nerveanatomical tracingbasebladder painchronic paindesignin vivo calcium imaginginsightmouse modelneural circuitneuromechanismneuronal circuitryoptogeneticspain processingreceptorresponsetherapeutic targettherapy developmenttranscriptome sequencingtranscriptomicstransmission process
中文摘要
摘要
间质性膀胱炎/膀胱痛综合征(IC/BPS)是一种虚弱的情况,失去对膀胱的控制和
严重的膀胱疼痛对膀胱充盈有影响。IC/BPS的潜在机制还知之甚少。令人信服的研究
表明通过直接投射到脊髓的脑干可以直接调节伤害性信息的处理
膀胱功能。在我们的初步研究中,我们已经确定了脑干神经元的不同群体
投射到脊髓。在这里,我们将确定这些不同的脑干神经元在
IC/BPS的病理学。我们将确定IC/BPS是否会导致这些不同群体的适应不良变化。
我们将使用光遗传学、解剖示踪、活体钙成像、切片电生理学和核糖核酸
测序以确定IC/BPS是否导致这些电路中细胞和系统级别的功能变化。
这些变化是否会驱动IC/BPS?逆转这些不适应变化能缓解IC/BPS吗?总而言之,这
这项工作将揭示这种神经回路在IC/BPS中的具体作用。这种丰富的信息可以有广泛的
在IC/BPS治疗中设计更安全的治疗药物的潜在新方向的含义。
英文摘要
Abstract
Interstitial cystitis/bladder pain syndromes (IC/BPS) is a debilitating condition with loss of bladder control and
severe bladder pain on bladder filling. Mechanisms underlying IC/BPS are poorly understood. Compelling studies
show that the brainstem via direct projection to the spinal cord can directly modulate nociceptive processing and
bladder function. In our preliminary studies, we have identified distinct populations of the brainstem neurons that
project to the spinal cord. Here we will determine the precise roles of these distinct brainstem neurons in the
pathology of IC/BPS. We will determine if IC/BPS leads to maladaptive changes in these distinct populations.
We will use optogenetics, anatomical tracing, in vivo calcium imaging, slice electrophysiology and RNA
sequencing to determine if IC/BPS leads to functional changes at the cellular and systems level in these circuits.
Do these changes drive IC/BPS? Does reversing these maladaptive changes relieve IC/BPS? Together, this
work will reveal the specific roles for this neural circuits in IC/BPS. This rich information can have broad
implications for potential new direction in designing safer therapeutic drugs in treatment of the IC/BPS.
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会议论文
Neural Mechanisms Underlying IC/BPS
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批准号:10182438
-
项目类别:
-
资助金额:$46.94万
-
财政年份:2021
-
负责人:Vijay K Samineni
-
依托单位:
Neural Mechanisms Underlying IC/BPS
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批准号:10594492
-
项目类别:
-
资助金额:$46.94万
-
财政年份:2021
-
负责人:Vijay K Samineni
-
依托单位:
DEFINING THE NEURAL BASIS FOR CHRONIC BLADDER PAIN AND ITS ASSOCIATED COMORBID DISORDERS
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批准号:9750743
-
项目类别:
-
资助金额:$11.62万
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财政年份:2018
-
负责人:Vijay K Samineni
-
依托单位:
DEFINING THE NEURAL BASIS FOR CHRONIC BLADDER PAIN AND ITS ASSOCIATED COMORBID DISORDERS
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批准号:9598623
-
项目类别:
-
资助金额:$11.77万
-
财政年份:2018
-
负责人:Vijay K Samineni
-
依托单位:
DEFINING THE NEURAL BASIS FOR CHRONIC BLADDER PAIN AND ITS ASSOCIATED COMORBID DISORDERS
-
批准号:10460640
-
项目类别:
-
资助金额:$11.62万
-
财政年份:2018
-
负责人:Vijay K Samineni
-
依托单位:
DEFINING THE NEURAL BASIS FOR CHRONIC BLADDER PAIN AND ITS ASSOCIATED COMORBID DISORDERS
-
批准号:10224824
-
项目类别:
-
资助金额:$11.62万
-
财政年份:2018
-
负责人:Vijay K Samineni
-
依托单位:
海外基金