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DEFINING THE NEURAL BASIS FOR CHRONIC BLADDER PAIN AND ITS ASSOCIATED COMORBID DISORDERS

定义慢性膀胱疼痛及其相关合并症的神经基础

基本信息

批准号：
10460640
负责人：
Vijay K Samineni
金额：
$ 11.62万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10460640
关键词：
Address Affect Affective Amygdaloid structure Anatomy Anesthesiology Anxiety Applications Grants Behavior Bladder Bladder Diseases Brain Brain region Cells Chronic Clinical Cystitis Development Disease Dissection Electrophysiology (science)Environment Etiology Funding Future Genetic Goals Halorhodopsins Interstitial Cystitis K-Series Research Career Programs Lead Left Light Local Therapy Maintenance Mediating Mental Depression Mentored Research Scientist Development Award Mentors Mood Disorders Neuraxis Neurons Nociception Pathology Patients Pelvic Pain Peripheral Personnel Management Population Process Pump Research Research Personnel Research Project Grants Research Proposals Rodent Role Running Scientist Series Slice Stimulus Supervision Symptoms Synapses Synaptic Transmission Syndrome System Techniques Testing Training United States United States National Institutes of Health Universities Urology Washington Woman Work Writing afferent nerve anatomical tracing base behavioral pharmacology bladder pain career career development cell type central sensitization chronic neuropathic pain chronic pain comorbidity experience experimental study in vivo inflammatory pain innovation insight meetings mouse model multidisciplinary negative affect neural circuit neuromechanism neuronal circuitry novel therapeutics optogenetics pain behavior programs psychosocial recruit relating to nervous system selective expression skills skills training therapeutic target tool

项目摘要

Project Summary The goal of this “Career Development Award” is to provide Dr. Samineni with a mentored neurourology research experience and to successfully bridge transition from mentored research to a career as an independent investigator as a neurourologist. Dr. Samineni’s primary goal in the next five years is to establish as a successful independent scientist conducting neurourology research that provides mechanistic insights into our understanding of chronic bladder pain and to obtain R01 level funding. The long-term goal of Dr. Samineni’s research is to independently lead a research group that investigates new avenues for relief of chronic bladder pain and identify new therapeutic opportunities through furthering our mechanistic understanding of chronic bladder pain. To achieve this goal, Dr. Samineni is proposing a project that provides him with significant training in neurourology. Training plan includes rigorous bench work under the primary supervision of Dr. Gereau and Dr. Andriole, attending urology focused grand rounds and didactic series, presentations at national meetings, and training in personnel management, grantsmanship and scientific writing. This training will enable Dr. Samineni to become an independent scientist in urology and allow him to be competitive in obtaining an independent NIH research grant (R01). The institutional environment for career development at Washington University and in the Department of Anesthesiology and Urology is exceptional. Dr. Evers (Chief of Anesthesiology) pledged his full department commitment. To achieve Dr. Samineni’s goal, he is proposing a project that provides him with significant training by examining how maladaptive plasticity in the central amygdala (CeA) circuit contributes to chronic bladder pain in IC/ BPS. Specifically, Dr. Samineni will examine necessity and sufficiency of these circuits in mediating chronic bladder pain. To test this, Dr. Samineni will use optogenetic techniques to control the activity of the CeA neurons and determine their relative contribution to bladder pain. This proposal combines Dr. Samineni’s prior expertise using rodent in vivo work, and pushes forward an innovative combination of genetics, electrophysiology and circuit dissecting tools. Successful completion of these studies will identify the maladaptive mechanisms in these circuits for processing chronic bladder pain and will provide new avenues for developing novel therapies and treatments that would be beneficial for the treatment of chronic bladder pain. Completion of this K01 award will train Dr. Samineni with comprehensive, multidisciplinary training in behavioral pharmacology, optogenetics and whole-cell slice electrophysiology. Furthermore, additional mentored training via the K01 mechanism will allow Dr. Samineni to bridge the gap in his training with regard to skills relevant to running an independent research program.

项目总结