University of Pittsburgh HIV-Comorbidities Research Training Program in South Africa

南非匹兹堡大学艾滋病毒合并症研究培训项目

• 批准号: 10401787
• 负责人: JEAN BISIMWA NACHEGA
• 金额: $ 29.92万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-30 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10401787
• 关键词: Active Learning; Address; Advisory Committees; Africa South of the Sahara; Aging; Caliber; California; Cardiovascular Diseases; Chronic Kidney Failure; Clinical; Consultations; Country; Development Plans; Doctor of Philosophy; Educational workshop; Ethics; Evaluation; Frequencies; HIV; Health Policy; Individual; Inflammation; Institution; Journals; Knowledge; Leadership; Life Expectancy; Life Style; Los Angeles; Mentors; Modeling; Monitor; Outcome; Population; Prevention strategy; Public Health; Research; Research Ethics; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; San Francisco; Seeds; South Africa; South African; Testing; Time; Toxic effect; Training; Training Programs; Translating; Universities; Writing; antiretroviral therapy; career development; clinical practice; comorbidity; cost effectiveness; design; effectiveness evaluation; experience; high risk; improved outcome; innovation; mortality; multiple chronic conditions; neuropsychiatric disorder; next generation; programs; recruit; skills; treatment strategy; web site

Although the life expectancy of HIV-infected individuals increases with effective antiretroviral therapy (ART) use, they remain at higher risk of multi-morbidity and mortality than the general HIV-uninfected population. Long-term ART-related toxicity, persistent inflammation, and lifestyle have been hypothesized as mechanisms for non-AIDS defined conditions such as cardiovascular disease (CVD), chronic kidney diseases (CKD), and neuropsychiatric disease (NPD), which are increasing in frequency with the aging of the HIV-infected population. Very little research has been conducted to quantify the burden of these three HIV-comorbidities or to design and evaluate the effectiveness and cost-effectiveness of preventive and treatment strategies in sub-Saharan Africa. Moreover, South Africa, the country with the highest burden of HIV globally, unfortunately has a paucity of qualified investigators to effect change in these HIV-comorbidities. The overall objective of the University of Pittsburgh HIV-comorbidities Research Training Program in South Africa (Pitt-HRTP-SA) is to build a critical mass of the next generation of basic, translational, clinical, and public health researchers at Stellenbosch University in Cape Town, to conduct high-quality research, generate new knowledge, improve outcomes, and become successful, independent investigators. The specific aims are: 1) To gain research methodology, ethics, leadership and management skills; 2) To conduct mentored HIV-CVD, CKD, and NPD research that address new, locally relevant questions and test meaningful hypotheses; 3) To become proficient in scientific presentations and writing, grantsmanship, research ethics and management; 4) To evaluate the outcomes of the program and make adjustments as needed and acquire skills to translate research findings into clinical practice and public health policies. We will achieve these aims using an innovative North-South and South- South triangular mentoring model. Each trainee will have one South African core mentor (affiliated with SU or University of Cape Town) and one US co-mentor (University of Pittsburgh; Johns Hopkins University; Harvard University; University of California, San Francisco; University of California, Los Angeles), short- term training experience at one of the collaborating US institutions. The strategies utilized to build and enhance research capacity will include: didactic coursework (Masters and/or PhD), mentored high-caliber research, experiential learning, pilot research grants, workshops, seminars, journal clubs, scientific writing retreats, and Pitt-HRTP-SA website resources. A Steering Committee, after consultation with an independent Training Advisory Committee, will approve the recruitment, research, monitoring, and evaluation of twelve highly competitive trainees, each of whom will be provided a seed research grant and up to 50% of protected research time up to 5 years. Each trainee will have an individualized career development plan that will be monitored and tracked throughout their tenure and after completion of the program.

虽然艾滋病毒感染者的预期寿命随着有效的抗逆转录病毒疗法的使用而增加， 与未感染艾滋病毒的一般人口相比，他们仍然面临更高的多重发病率和死亡率风险。 长期ART相关毒性、持续性炎症和生活方式被假设为 非艾滋病定义的疾病，如心血管疾病（CVD），慢性肾脏疾病， 慢性肾脏病（CKD）和神经精神疾病（NPD），这些疾病的发生频率随着年龄的增长而增加 艾滋病毒感染者的数量。很少有研究已经进行量化的负担，这些 三种艾滋病毒合并症或设计和评估预防的有效性和成本效益 和治疗策略。此外，南非， 全球艾滋病毒的负担，不幸的是，缺乏合格的调查人员来改变这些 HIV合并症。匹兹堡大学艾滋病毒合并症研究培训的总体目标 在南非的计划（Pitt-HRTP-SA）是建立一个临界质量的下一代基本， 开普敦斯泰伦博斯大学的翻译、临床和公共卫生研究人员， 高质量研究、产生新知识、改善成果并取得成功， 独立调查员。具体目标是：1）获得研究方法，道德，领导力 和管理技能; 2）进行指导HIV-CVD，CKD和NPD研究，以解决新的，当地 相关问题和测试有意义的假设; 3）精通科学演示 4）评估研究成果， 计划并根据需要进行调整，并获得将研究结果转化为临床研究的技能。 实践和公共卫生政策。我们将通过创新的北南和南南合作实现这些目标， 南三角指导模式。每个受训者将有一名南非核心导师（附属于SU 或开普敦大学）和一名美国共同导师（匹兹堡大学;约翰霍普金斯大学; 哈佛大学;加州大学弗朗西斯科分校;加州大学洛杉矶分校），短- 在美国合作机构之一的长期培训经验。用于建立和 提高研究能力将包括：教学课程（硕士和/或博士），指导高素质 研究，体验式学习，试点研究赠款，讲习班，研讨会，期刊俱乐部，科学 写作务虚会和Pitt-HRTP-SA网站资源。一个指导委员会，在与一个 独立的培训咨询委员会将批准招聘、研究、监督和评估 12名竞争力很强的学员，每人将获得种子研究补助金， 受保护的研究时间长达5年。每个受训者都将有一个个性化的职业发展计划 在他们的任期内和项目完成后，将对其进行监测和跟踪。