DBPs
舒张压
基本信息
- 批准号:10401764
- 负责人:
- 金额:$ 31.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-08-01 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAutomobile DrivingBackBiologicalCellsChromatinCommunitiesComplexCytoplasmDNADevelopmentEnsureFundingGenerationsGenetic TranscriptionMethodologyMethodsMicroscopeModelingMolecularMorphologyOrganellesPaperPathway interactionsPreparationProcessProteinsRNAReagentResearchResearch PersonnelSamplingSignal TransductionStructureTechniquesTechnologyTestingTimeTrainingTranslationsfeedingmeetingsmembermethod developmentmodel developmentstoichiometrytechnology developmenttool
项目摘要
PROJECT SUMMARY
Driving Biomedical Projects Portfolio
To drive the development of our molecular microscope pipeline, we have selected Driving Biomedical Projects
(DBPs) that serve as the first stage in applying and testing NCDIR technologies. Each DBP contains one or more
key specific technological roadblocks that have been generally acknowledged by the field and that must be
overcome by the development and optimization of technologies at different stages in our pipeline. Collectively,
these DBPs are selected to test all the technology in this pipeline: helping develop sample preparation methods
and ways to isolate intact native assemblies; ensuring the development and refinement of methods that
determine the composition, stoichiometry, morphology and connectivity of isolated complexes; and projects that
challenge the development of methods for modeling static structures of large macromolecular machines as well
as dynamic processes involving these machines on long time scales. We have also selected these DBPs to
represent different biological problems, key pieces of the “cellular information pathway” that starts with signalling
to a cell, leading to reorganization and activation of DNA in chromatin for transcription into RNA, which is
processed, packaged, and exported into the cytoplasm where its translation into protein leads to the generation
of new assemblies, structures, and organelles. These DBPs are therefore a key metric for the efficacy of our
technologies in both solving key technical roadblocks and addressing key biomedical challenges in the research
community we serve. In doing so, we will generate new tools, techniques, and reagents for interactomic studies,
train DBP members in the molecular microscope pipeline approaches, begin the dissemination of these
approaches to a wider group of researchers both through this training and presentation in meetings and papers,
and aid the stabilization of these approaches for a sustainable presence in the community. We also expect
application of our TR&D technology in the DBPs to generate new challenges, feeding back to help drive new
aspects of our ongoing TR&D development and maturation.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MICHAEL P ROUT其他文献
MICHAEL P ROUT的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MICHAEL P ROUT', 18)}}的其他基金
Altered Communication between the nucleus and the mitochondria under oncogenic states
致癌状态下细胞核与线粒体之间通讯的改变
- 批准号:
10016218 - 财政年份:2019
- 资助金额:
$ 31.03万 - 项目类别:
Altered Communication between the nucleus and the mitochondria under oncogenic states
致癌状态下细胞核与线粒体之间通讯的改变
- 批准号:
10688189 - 财政年份:2019
- 资助金额:
$ 31.03万 - 项目类别:
Altered Communication between the nucleus and the mitochondria under oncogenic states
致癌状态下细胞核与线粒体之间通讯的改变
- 批准号:
10248415 - 财政年份:2019
- 资助金额:
$ 31.03万 - 项目类别:
Altered Communication between the nucleus and the mitochondria under oncogenic states
致癌状态下细胞核与线粒体之间通讯的改变
- 批准号:
9764927 - 财政年份:2019
- 资助金额:
$ 31.03万 - 项目类别:
National Center for Dynamic Interactome Research
国家动态相互作用组研究中心
- 批准号:
9063390 - 财政年份:2015
- 资助金额:
$ 31.03万 - 项目类别:
Equipment Supplement for the National Center for Dynamic Interactome Research
国家动态相互作用组研究中心的设备补充
- 批准号:
10392609 - 财政年份:2014
- 资助金额:
$ 31.03万 - 项目类别:
National Center for Dynamic Interactome Research
国家动态相互作用组研究中心
- 批准号:
10401758 - 财政年份:2014
- 资助金额:
$ 31.03万 - 项目类别:
National Center for Dynamic Interactome Research
国家动态相互作用组研究中心
- 批准号:
10621352 - 财政年份:2014
- 资助金额:
$ 31.03万 - 项目类别:
相似海外基金
Establishment of a method for evaluating automobile driving ability focusing on frontal lobe functions and its application to accident prediction
以额叶功能为中心的汽车驾驶能力评价方法的建立及其在事故预测中的应用
- 批准号:
20K07947 - 财政年份:2020
- 资助金额:
$ 31.03万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Evaluation of the Effectiveness of Multi-Professional Collaborative Assessment of Cognitive Function and Automobile Driving Skills and Comprehensive Support
认知功能与汽车驾驶技能多专业协同评估效果评价及综合支持
- 批准号:
17K19824 - 财政年份:2017
- 资助金额:
$ 31.03万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Development of Flexible Automobile Driving Interface for Disabled People
残疾人灵活汽车驾驶界面开发
- 批准号:
25330237 - 财政年份:2013
- 资助金额:
$ 31.03万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Automobile driving among older people with dementia: the effect of an intervention using a support manual for family caregivers
患有痴呆症的老年人的汽车驾驶:使用家庭护理人员支持手册进行干预的效果
- 批准号:
23591741 - 财政年份:2011
- 资助金额:
$ 31.03万 - 项目类别:
Grant-in-Aid for Scientific Research (C)














{{item.name}}会员




