Implementation and Evaluation at Northwestern Medicine of Shareable EHR Treatment Plans in support of Multi-Site Clinical Trials

罗伯特·H。西北大学Lurie综合癌症中心（LCC）认识到， 在电子健康记录（EHR）中实施临床试验治疗计划是及时 激活所有来源的临床试验，包括NCTN。LCC临床试验和信息学专家蓄势待发 与其他国家癌症研究所支持的癌症中心的同行合作，开发工具和标准流程， 并协调多中心临床试验的EHR治疗计划制定。这一努力将需要谨慎的 分析现有的治疗计划，以建立一个共同的信息模型。信息模型可以是 用于创建EHR治疗计划的单个实例，然后可由参与站点快速采用 因为他们的地方背景。我们计划利用十大癌症研究机构内已建立的合作伙伴关系， 联盟和拟议的十大电子健康记录联盟，以应对这一挑战， 与NCI和EHR供应商协调。具体而言，我们将：（1）分析以前的治疗计划， 开发一个全球站点不可知的信息模型，用于与 十大EHRC，并确定在LCC实施EHR治疗计划的特定属性 及其最大的临床附属机构，西北医学（NM）;（2）参与社区发展， 新的工具包，加快NCTN临床试验的激活，使用统一的EHR实施， 治疗计划。这将通过专家的努力-临床试验人员和信息学家- 技术开发，并在当地LCC中试行实施全球信息学工件 和NM系统;以及（3）Prominent在NM本地验证EHR治疗计划的实施， 在全球范围内的合作机构。

The Robert H. Lurie Comprehensive Cancer Center (LCC) at Northwestern University recognizes that implementation for clinical trial treatment plans in the Electronic Health Record (EHR) is an impediment to timely activation of clinical trials of all sources, including the NCTN. LCC clinical trial and informatics experts are poised to work with peers in other NCI-supported Cancer Centers to develop tools and standard processes to streamline and harmonize EHR treatment plan development for multi-site clinical trials. This effort will require the careful analysis of existing treatment plans to establish a common information model. The information model can be used to create a single instance of EHR treatment plans which can then be quickly adopted by participating sites for their local context. We plan to leverage the established partnerships within the Big Ten Cancer Research Consortium and the proposed Big Ten Electronic Health Record Consortium for tackling this challenge in coordination with the NCI and with EHR vendors. Specifically, we will: (1) Analyze previous treatment plans to develop a global site-agnostic information model for representing EHR treatment plans in collaboration with the Big Ten-EHRC and to identify the attributes that are specific for implementation of EHR treatment plans at LCC and its largest clinical affiliate, Northwestern Medicine (NM); (2) Participate in the communal development of novel toolkits that expedite the activation of NCTN clinical trials using harmonized EHR implementation of treatment plans. This will be achieved by contribution of expert effort – clinical trialists and informaticists – towards technical development, and by piloting the implementation of global informatics artifacts in local LCC and NM systems; and (3) Prospectively validate this EHR treatment plan implementation both locally at NM and globally across the collaborating institutions.