Incorporation of Zinc and Nickel Complexes that Bind H2S and HS in ChemFET Sensing Devices

在 ChemFET 传感器件中结合结合 H2S 和 HS 的锌和镍络合物

• 批准号: 10231809
• 负责人: Tobias J Sherbow
• 金额: $ 6.64万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10231809
• 关键词: Acidity; Address; Affinity; Amines; Anions; Architecture; Bicarbonates; Binding; Biological; Biomedical Research; Biomimetics; Buffers; Carbon Monoxide; Chemicals; Chemistry; Chlorides; Complex; Coupled; Data; Detection; Development; Devices; Educational workshop; Electrons; Elements; Enrollment; Environment; Environmental Monitoring; Exhibits; Faculty; Formulation; Gases; Goals; Hydrocarbons; Hydrogen Sulfide; Industry; Institutes; Interdisciplinary Study; Laboratories; Learning; Ligands; Market Research; Measures; Medical Research; Metals; Methods; Modification; Molecular; Molecular Biology; Monitor; Natural Gas; Nickel; Nitric Oxide; Occupations; Petroleum; Pharmacology; Physiological; Play; Polymers; Porphyrins; Postdoctoral Fellow; Prevalence; Production; Property; Research; Research Personnel; Research Proposals; Role; Running; Sampling; Science; Scientist; Source; Spectrum Analysis; Structure; System; Testing; Time; Titrations; Toxic effect; Transistors; Transition Elements; United States; Water; Work; Zinc; Zn(II)-phthalocyanine; analog; aqueous; base; career; design; detection limit; detection sensitivity; expectation; experience; improved; innovation; inorganic phosphate; lens; materials science; member; metal complex; molecular recognition; new technology; novel strategies; programs; protonation; response; sensor; sensor technology; small molecule

Project Summary/Abstract Hydrogen sulfide (H2S) is an important analytical target for sensing applications in diverse settings, including the environment, biomedical sciences, and petroleum and natural gas industries. Preliminary results from my work in the Pluth/Johnson laboratories has established the feasibility of using ChemFET architectures to detect hydrosulfide (HS–) anion in aqueous solution. This approach leverages the detection of HS–, which is the most prevalent protonation state of H2S under physiological conditions, by direct molecular recognition. Although these preliminary results provide the first example of detecting HS– with a ChemFET, the initial limit of detection (LoD) of 8 mM is currently only applicable in the natural gas industry; significantly lower detection limits are needed for environmental monitoring or in biological settings. In order to improve the applicability of these HS– sensing devices I will build new recognition elements in the ChemFET platform. The key innovative element of this research proposal is to further develop H2S and HS– recognition chemistry by using a new approach of synthesizing molecular metal complexes that have strong binding interactions with H2S and HS– and incorporating them into ChemFET architectures that have proven to show concertation dependent responses to HS– in aqueous solution. My extensive experience as a synthetic inorganic chemist coupled with my experience as a post-doctoral researcher that has developed ChemFETs to sense a variety of analytes prepares me well to develop new technologies for H2S or HS– detection. In addition to the proposed research and as part of my professional development to advance my career goals of building a start-up company or working in industry, I am excited to enroll and continue to participate in the Lens of the Market (LOTM) workshop. LOTM is a three-stage program designed for scientists to learn about the value of research in addressing the challenges faced by people in the real world. It also aims to provide networking for job and career opportunities. I will perform market research in the field of sensing to pair sensing technologies with specific market needs. I have completed stages one and two of the LOTM program and I will continue on to stage three. Lastly, the environment in which the research will be performed is an interdisciplinary research environment. I interact regularly with my sponsor and cosponsor who are experts in the field of sensing, supramolecular chemistry, small molecule binding in metal complexes and hydrogen sulfide related chemistry. Many faculty members, including Profs. Pluth and Johnson (sponsors), are members of cross-department institutes, such as the Materials Science Institute, Knight Campus for Accelerating Scientific Impact, and the Institute of Molecular Biology, which provides me with an additional breadth of interactions.

项目概要/摘要 硫化氢 (H2S) 是多种环境下传感应用的重要分析目标，包括 环境、生物医学科学以及石油和天然气工业。我的初步结果 Pluth/Johnson 实验室的工作已经确立了使用 ChemFET 架构检测的可行性 水溶液中的氢硫化物 (HS–) 阴离子。这种方法利用了 HS– 的检测，这是最 通过直接分子识别，生理条件下 H2S 普遍的质子化状态。虽然这些 初步结果提供了使用 ChemFET 检测 HS 的第一个示例，初始检测限 (LoD) 8 mM 目前仅适用于天然气行业；需要显着降低的检测限 环境监测或生物环境。为了提高这些 HS 传感的适用性 我将在 ChemFET 平台中构建新的识别元件。该方案的关键创新要素 研究计划是通过使用新方法进一步开发 H2S 和 HS 识别化学 合成与 H2S 和 HS- 具有强结合相互作用的分子金属配合物 将它们合并到 ChemFET 架构中，该架构已被证明能够表现出协调依赖的响应 HS——水溶液。我作为合成无机化学家的丰富经验加上我的经验 作为一名博士后研究员，我开发了 ChemFET 来感应各种分析物，这让我做好了充分的准备 开发 H2S 或 HS- 检测新技术。 除了拟议的研究之外，作为我职业发展的一部分，以推进我的职业目标 无论是建立一家初创公司还是在行业中工作，我很高兴能够注册并继续参与 市场透镜 (LOTM) 研讨会。 LOTM 是一个三阶段计划，旨在让科学家了解 研究在解决人们在现实世界中面临的挑战方面的价值。它还旨在提供 工作和职业机会的网络。我将在传感领域进行配对传感市场研究 具有特定市场需求的技术。我已完成 LOTM 计划的第一阶段和第二阶段，我将 继续进入第三阶段。 最后，进行研究的环境是跨学科的研究环境。 我定期与我的赞助人和共同赞助人互动，他们是传感、超分子领域的专家 化学、金属配合物中的小分子结合和硫化氢相关化学。师资众多 成员，包括教授。普卢斯和约翰逊（发起人）是跨部门研究所的成员，例如 材料科学研究所、加速科学影响奈特校区和分子研究所 生物学为我提供了更广泛的互动。