Incorporation of Zinc and Nickel Complexes that Bind H2S and HS in ChemFET Sensing Devices

项目摘要/摘要 硫化氢(H_2S)是各种环境中传感应用的重要分析目标，包括 环境、生物医学、石油和天然气工业。来自我的初步结果 Pluth/Johnson实验室的工作已经确定了使用ChemFET架构来检测 水溶液中的硫化氢(HS-)阴离子。这种方法利用了对HS-的检测，HS-是最 通过直接分子识别，在生理条件下H_2S的普遍质子化状态。尽管这些 初步结果提供了用ChemFET检测HS-的第一个例子，即初始检测限(LOD) 8毫米目前仅适用于天然气行业；需要显著降低的检测下限 环境监测或在生物环境中。为了提高这些HS-传感的适用性 Device I将在ChemFET平台中构建新的识别元素。这其中的关键创新元素 研究建议是通过使用一种新的方法来进一步发展硫化氢和HS识别化学 与H_2S和HS-具有较强结合作用的分子金属络合物的合成 将它们整合到ChemFET架构中，事实证明，这些架构对 HS-在水溶液中。我作为一名合成无机化学家的丰富经验和我的经验 作为一名博士后研究员，我已经开发出能够检测各种分析物的化学FET，这让我做好了很好的准备 开发新的硫化氢或HS检测技术。 除了建议的研究外，作为我职业发展的一部分，以推进我的职业目标 无论是创办一家初创公司还是在行业工作，我都很兴奋能报名并继续参与 市场镜头(LOTM)研讨会。LOTM是一个分为三个阶段的计划，旨在让科学家了解 研究在解决现实世界中的人们所面临的挑战方面的价值。它还旨在提供 为工作和职业机会建立关系网。我将在感应到配对感应领域进行市场调查 具有特定市场需求的技术。我已经完成了LOTM计划的第一和第二阶段，我将 继续进行到第三阶段。 最后，进行研究的环境是一个跨学科的研究环境。 我经常与我的赞助人和共同发起人互动，他们是超分子传感领域的专家 化学、金属络合物中的小分子结合和与硫化氢有关的化学。许多教职员工 成员，包括教授。Pluth和Johnson(赞助商)是跨部门研究所的成员，如 材料科学研究所、加速科学影响骑士校园和分子研究所 生物学，它为我提供了额外的互动广度。

Project Summary/Abstract Hydrogen sulfide (H2S) is an important analytical target for sensing applications in diverse settings, including the environment, biomedical sciences, and petroleum and natural gas industries. Preliminary results from my work in the Pluth/Johnson laboratories has established the feasibility of using ChemFET architectures to detect hydrosulfide (HS–) anion in aqueous solution. This approach leverages the detection of HS–, which is the most prevalent protonation state of H2S under physiological conditions, by direct molecular recognition. Although these preliminary results provide the first example of detecting HS– with a ChemFET, the initial limit of detection (LoD) of 8 mM is currently only applicable in the natural gas industry; significantly lower detection limits are needed for environmental monitoring or in biological settings. In order to improve the applicability of these HS– sensing devices I will build new recognition elements in the ChemFET platform. The key innovative element of this research proposal is to further develop H2S and HS– recognition chemistry by using a new approach of synthesizing molecular metal complexes that have strong binding interactions with H2S and HS– and incorporating them into ChemFET architectures that have proven to show concertation dependent responses to HS– in aqueous solution. My extensive experience as a synthetic inorganic chemist coupled with my experience as a post-doctoral researcher that has developed ChemFETs to sense a variety of analytes prepares me well to develop new technologies for H2S or HS– detection. In addition to the proposed research and as part of my professional development to advance my career goals of building a start-up company or working in industry, I am excited to enroll and continue to participate in the Lens of the Market (LOTM) workshop. LOTM is a three-stage program designed for scientists to learn about the value of research in addressing the challenges faced by people in the real world. It also aims to provide networking for job and career opportunities. I will perform market research in the field of sensing to pair sensing technologies with specific market needs. I have completed stages one and two of the LOTM program and I will continue on to stage three. Lastly, the environment in which the research will be performed is an interdisciplinary research environment. I interact regularly with my sponsor and cosponsor who are experts in the field of sensing, supramolecular chemistry, small molecule binding in metal complexes and hydrogen sulfide related chemistry. Many faculty members, including Profs. Pluth and Johnson (sponsors), are members of cross-department institutes, such as the Materials Science Institute, Knight Campus for Accelerating Scientific Impact, and the Institute of Molecular Biology, which provides me with an additional breadth of interactions.