Core D: Program Administration

计划管理核心将通过提供行政和 财政支持以及科学监督，以确保该计划的活动符合其 最终目标，即为非小细胞肺癌开发新的靶向治疗。这涉及 协调所有计划活动，特别是促进合作、交流和分享 各种项目和核心之间的信息和想法。这包括评估和 根据需要改变研究轨迹，以确保研究进展和 活动与方案的总体目标。这将通过以下具体目标来实现： 具体目标1：监控项目和共享资源核心，评估整体研究进展。 a）协调包括每个项目负责人在内的计划执行委员会的定期会议， 核心董事，监督每个项目和共享资源核心的进度。 B）为项目负责人和核心主管提供定期指导，包括对以下方面进行批判性评估： 研究进展和方向。 c）从Dana-Farber癌症研究所内部科学家咨询委员会获得建议， 监督将委员会的建议纳入项目和核心的绩效。 d）举行由具有肺癌靶向治疗专门知识的科学家组成的外部咨询委员会会议。 具体目标2：促进项目和共享资源核心之间的协作和沟通。 a）安排本计划的双周小组会议，分享研究思路、成果和方法。 B）监控和鼓励项目与核心之间的互动。 具体目标3：为方案提供财政监督和支持。 （a）协助赠款管理和资金支付。 B）分析和调整预算，以纳入正在进行的创新和随着计划的发展。 具体目标4：促进该项目诊断和治疗发现的临床转化。 a）确保将可翻译的发现有效地传达给丹娜-法伯/哈佛癌症中心 中心肺癌项目。 B）组织一次务虚会，传播研究结果，促进协同互动。 c）协助稿件提交和后续出版。

The Program Administration Core will facilitate the overall goals of the Program by providing administrative and fiscal support as well as scientific oversight, to ensure that the activities of the Program are consistent with its ultimate goal i.e. the development of new targeted therapies for non-small cell lung cancer. This involves coordination of all Programmatic activities, in particular promoting collaboration, cross-talk and sharing of information and ideas between the various Projects and Cores. This includes the assessment and implementation of changes in research trajectory, as required, to ensure research progress and alignment of activities with the overall goals of the program. This will be accomplished via the following Specific Aims: Specific Aim 1: Monitor projects and shared resource cores and evaluate overall research progress. a) Coordinate regular meetings of a Program Executive Committee, including each of the Project Leaders and Core Directors, to monitor the progress of each Project and Shared Resource Core. b) Provide regular guidance to the Project Leaders and Core Directors, including critical evaluation of research progress and direction. c) Obtain advice from an Internal Advisory Committee of scientists within Dana-Farber Cancer Institute, and monitor the integration of the committee’s suggestions into the performance of the Projects and Cores. d) Hold meetings of an External Advisory Board of scientists with expertise in lung cancer targeted therapies. Specific Aim 2: Foster collaboration and communication among the projects and shared resource cores. a) Arrange bi-weekly group meetings of the Program to share research ideas, results, and methods. b) Monitor and encourage the interactions between projects and cores. Specific Aim 3: Provide fiscal oversight and support for the program. a) Assist with grants management and disbursement of funds. b) Analyze and adjust budgets to incorporate ongoing innovations and as the program evolves. Specific Aim 4: Promote the clinical translation of diagnostic and therapeutic discoveries from the program. a) Ensure that translatable discoveries are effectively communicated to the Dana-Farber/Harvard Cancer Center Lung Cancer Program. b) Organize a retreat to disseminate the research findings and prompt synergistic interactions. c) Assist in manuscript submission and subsequent publication.