HIV and Drug Abuse Prevention Research Ethics Training Institute

项目总结 全球艾滋病毒/艾滋病大流行、药物使用模式的转变以及干预研究设计的进步，都创造了新的 在艾滋病毒和药物滥用的交叉点上进行研究的伦理挑战。到目前为止，合格的人才还很少。 调查人员经过培训，进行科学严谨的研究，为应对这些挑战的政策提供信息。这个 这次更新的目标是促进福特汉姆大学艾滋病毒和药物滥用预防研究的贡献 道德培训学院(RETI)是此类项目中唯一满足这一需求的机构。的广泛的长期目标 RETI将培养新一代科学家，他们将进行稳健和不偏不倚的设计，以告知研究伦理 对艾滋病毒携带者和有滥用药物风险的个人的独特需求敏感的做法，并扩大 该计划通过在线科学和教学资源产生的全球影响。这些目标是通过 遵循目标。目标1：提高早期职业临床科学家进行严谨和可重复操作的能力 艾滋病毒和药物滥用预防研究的实证研究、伦理实践和政策。合乎道德的决定 调查员和IRBs/REC往往以对措辞宽泛的条例和准则的主观解释为指导。 因此，需要关于道德实践和政策的经验数据，以便更好地为这些决定提供信息。目标1将解决这一问题 需要通过Reti指导研究项目(MRP)，这是一种多年资助的研究经验，受训者 获得设计、实施、分析和传播艾滋病毒原创研究的密集监督经验 和药物滥用研究伦理。MRP将与一年一度的Reti Summer Institute一起进行 将在独特的概念框架和研究设计中培养学员的能力，以进行以下方面的研究 研究伦理。目标1还将通过职业发展活动实现，旨在加强出版和 提高写作技能，并通过一系列新的公开网络研讨会传播学员的作品。目标2：提早增加 职业临床科学家让社区参与艾滋病毒和药物滥用参与者建设的能力 保护措施。虽然社区咨询委员会(CAB)现在在艾滋病毒和药物滥用研究中很常见，但很少有 课程教学员如何让适当的利益相关者参与研究设计和开发 保护参与者权利和福利的程序。这往往导致对潜在参与者的授权有限 作为合作伙伴。目标2将通过夏季学院关于吸引潜在客户的方法的研讨会来实现 参与与道德有关的对话，并在设计和解释阶段纳入社区咨询委员会 有指导意义的研究项目。目标3：创建和维持一个全球信息网络，以加强道德操守 艾滋病毒和药物滥用预防研究伦理的知识和循证伦理实践、政策和教学。 目标3将通过扩大Reti的全球在线艾滋病毒和药物滥用研究伦理科学和 教学资源。作为一项新功能，RETI将促进调查人员和 通过创建社区研究伦理访问(CARE)，这是一个专门为 将研究伦理科学带给艾滋病毒和药物滥用研究中所代表的社区和人口。

PROJECT SUMMARY The global HIV/AIDS pandemic, shifts in drug use patterns, and advances in intervention research designs, all create new ethical challenges for studies at the intersection of HIV and drug abuse. To date, there is a paucity of well-qualified investigators trained to conduct scientifically rigorous studies to inform policies directed at meeting these challenges. The goal of this renewal is to advance the contributions of the Fordham University HIV and Drug Abuse Prevention Research Ethics Training Institute (RETI), the only program of its kind, to meet this need. The broad long-term objectives of the RETI are to train a new generation of scientists who will conduct robust and unbiased designs to inform research ethics practices sensitive to the unique needs of individuals with and at-risk for HIV and substance abuse and to extend the program's global impact through online scientific and pedagogical resources. These objectives are met through the following aims. Aim 1: To increase early career clinical scientists' capacity to conduct rigorous and reproducible empirical research on HIV and drug abuse prevention research ethics practices and policies. Ethical decisions by investigators and IRBs/RECs are often guided by subjective interpretations of broadly worded regulations and guidelines. Empirical data on ethics practices and policies is thus needed to better inform these decisions. Aim 1 will address this need through the RETI mentored research project (MRP), a multi-year funded research experience in which trainees receive intensive supervised experience designing, implementing, analyzing and disseminating an original study on HIV and drug abuse research ethics. The MRP will be conducted in conjunction with the annual RETI Summer Institute that will build trainee competencies in the unique conceptual frameworks and research designs for conducting studies on research ethics. Aim 1 will also be achieved through career development activities designed to enhance publication and grant writing skills and to disseminate trainees' work through a new public webinar series. Aim 2: To increase early career clinical scientists' capacity to engage communities in the construction of HIV and drug abuse participant protections. Although community advisory boards (CABs) are now commonplace in HIV and drug abuse research, few programs teach trainees how to involve appropriate stakeholders in the development of the study design and the procedures to protect participant rights and welfare. This has often led to limited empowerment of prospective participants as collaborative partners. Aim 2 will be achieved through Summer Institute seminars on methods to engage prospective participants in ethics-relevant dialogue and inclusion of community advisory boards at the design and interpretation stages of the mentored research project. Aim 3: To create and sustain a global information network for enhancing ethical knowledge and evidence-based ethics practices, policies and pedagogy for HIV and drug abuse prevention research ethics. Aim 3 will be achieved through expansion of RETI's global online HIV and drug abuse research ethics scientific and pedagogical resources. As a new feature, the RETI will promote transformative partnerships between investigators and communities by creating Community Access to Research Ethics (CARE), a social media platform specifically tailored to bring research ethics science to communities and populations represented in HIV and drug abuse research.