HIV and Drug Abuse Prevention Research Ethics Training Institute

项目摘要 全球艾滋病毒/艾滋病的流行、吸毒模式的转变以及干预研究设计的进步，都创造了新的 艾滋病毒和药物滥用交叉研究的伦理挑战。到目前为止，合格的 经过培训的调查人员进行科学严谨的研究，为旨在应对这些挑战的政策提供信息。的 这次更新的目的是促进福德姆大学艾滋病毒和药物滥用预防研究的贡献 道德培训学院（RETI），这是唯一的同类计划，以满足这一需求。的广泛的长期目标， RETI将培养新一代科学家，他们将进行稳健和公正的设计，以告知研究伦理 对艾滋病毒感染者和有感染风险的人的特殊需要敏感的做法， 通过在线科学和教学资源，该计划的全球影响力。这些目标是通过 的目标。目标1：提高早期职业临床科学家进行严格和可重复性研究的能力 关于艾滋病毒和药物滥用预防研究、道德操守做法和政策的实证研究。道德决策， 研究者和IRB/REC经常受到对措辞宽泛的法规和指南的主观解释的指导。 因此，需要关于道德操守做法和政策的经验数据，以便更好地为这些决定提供信息。目标1将解决这一问题 需要通过RETI指导研究项目（MRP），一个多年资助的研究经验，其中学员 接受密集的监督经验设计，实施，分析和传播艾滋病毒的原始研究 和药物滥用研究伦理MRP将与年度RETI暑期研究所一起进行， 将在独特的概念框架和研究设计中培养受训者的能力， 研究伦理目标1还将通过职业发展活动来实现，这些活动旨在加强出版和 授予写作技能，并通过一个新的公开网络研讨会系列传播学员的工作。目标2：尽早增加 职业临床科学家的能力，使社区参与建设艾滋病毒和药物滥用参与者 保护。虽然社区咨询委员会（CAB）现在在艾滋病毒和药物滥用研究中很常见，但很少有 课程教导学员如何让适当的利益相关者参与研究设计的开发， 保护参与者权利和福利的程序。这往往导致对潜在参与者的授权有限 作为合作伙伴。目标2将通过暑期研究所研讨会来实现，研讨会将讨论如何让未来的 参与与道德操守有关的对话，并在设计和解释阶段纳入社区咨询委员会 的研究项目。目标3：建立和维持一个全球信息网络， 艾滋病毒和药物滥用预防研究伦理方面的知识和循证伦理做法、政策和教学法。 目标3将通过扩大RETI的全球在线艾滋病毒和药物滥用研究伦理科学和 教学资源。作为一项新功能，RETI将促进调查人员之间的变革性伙伴关系， 通过创建社区访问研究伦理（CARE），这是一个专门针对 将研究伦理学带到参与艾滋病毒和药物滥用研究的社区和人群中。

PROJECT SUMMARY The global HIV/AIDS pandemic, shifts in drug use patterns, and advances in intervention research designs, all create new ethical challenges for studies at the intersection of HIV and drug abuse. To date, there is a paucity of well-qualified investigators trained to conduct scientifically rigorous studies to inform policies directed at meeting these challenges. The goal of this renewal is to advance the contributions of the Fordham University HIV and Drug Abuse Prevention Research Ethics Training Institute (RETI), the only program of its kind, to meet this need. The broad long-term objectives of the RETI are to train a new generation of scientists who will conduct robust and unbiased designs to inform research ethics practices sensitive to the unique needs of individuals with and at-risk for HIV and substance abuse and to extend the program's global impact through online scientific and pedagogical resources. These objectives are met through the following aims. Aim 1: To increase early career clinical scientists' capacity to conduct rigorous and reproducible empirical research on HIV and drug abuse prevention research ethics practices and policies. Ethical decisions by investigators and IRBs/RECs are often guided by subjective interpretations of broadly worded regulations and guidelines. Empirical data on ethics practices and policies is thus needed to better inform these decisions. Aim 1 will address this need through the RETI mentored research project (MRP), a multi-year funded research experience in which trainees receive intensive supervised experience designing, implementing, analyzing and disseminating an original study on HIV and drug abuse research ethics. The MRP will be conducted in conjunction with the annual RETI Summer Institute that will build trainee competencies in the unique conceptual frameworks and research designs for conducting studies on research ethics. Aim 1 will also be achieved through career development activities designed to enhance publication and grant writing skills and to disseminate trainees' work through a new public webinar series. Aim 2: To increase early career clinical scientists' capacity to engage communities in the construction of HIV and drug abuse participant protections. Although community advisory boards (CABs) are now commonplace in HIV and drug abuse research, few programs teach trainees how to involve appropriate stakeholders in the development of the study design and the procedures to protect participant rights and welfare. This has often led to limited empowerment of prospective participants as collaborative partners. Aim 2 will be achieved through Summer Institute seminars on methods to engage prospective participants in ethics-relevant dialogue and inclusion of community advisory boards at the design and interpretation stages of the mentored research project. Aim 3: To create and sustain a global information network for enhancing ethical knowledge and evidence-based ethics practices, policies and pedagogy for HIV and drug abuse prevention research ethics. Aim 3 will be achieved through expansion of RETI's global online HIV and drug abuse research ethics scientific and pedagogical resources. As a new feature, the RETI will promote transformative partnerships between investigators and communities by creating Community Access to Research Ethics (CARE), a social media platform specifically tailored to bring research ethics science to communities and populations represented in HIV and drug abuse research.