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Alzheimer's Disease Research Center

阿尔茨海默病研究中心

基本信息

批准号：
10406865
负责人：
Mary Sano
金额：
$ 304.2万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10406865
关键词：
Alzheimer&apos s Disease Alzheimer&apos s disease pathology Alzheimer&apos s disease related dementia Amyloid Area Autopsy Awareness Big Data Big Data Methods Biological Biological Markers Biological Process Biology Blood Blood Vessels Body Fluids Brain Brain region Characteristics Clinical Clinical Course of Disease Clinical Trials Design Cognitive deficits Collection Communities Complex Computerized Medical Record Data Data Science Data Set Data Sources Dementia Detection Development Discipline Disease Disease model Economics Ensure Environment Epigenetic Process Excision Exhibits Faculty Faculty Recruitment Failure Fostering Functional Imaging Genetic Genomics Goals Growth Health Heterogeneity Human Image Impaired cognition Individual Informatics Infrastructure Institutes Institution Intervention Knowledge Leadership Life Location Medical center Methods Mission Nerve Degeneration Pain Participant Pathogenicity Pathology Patients Pharmacology Phenotype Plasma Population Population Heterogeneity Preparation Proteomics Recording of previous events Research Research Personnel Resources Risk Sampling Science Scientific Inquiry Secure Specimen Supercomputing Symptoms System Tauopathies Technology Therapeutic Time Tissues Training Translational Research Traumatic Brain Injury Underrepresented Minority Underrepresented Populations United States Department of Veterans Affairs Ursidae Family base biological heterogeneity clinical biomarkers clinical heterogeneity clinically relevant cohort computerized tools convict design disease heterogeneity education research exosome experience genetic analysis genome wide association study improved induced pluripotent stem cell innovation institutional capacity interdisciplinary collaboration medical schools microbiome molecular imaging molecular phenotype multidisciplinary multiple omics neuropathology new technology novel outreach patient engagement prevent recruit research clinical testing scientific computing skills stressor success therapeutic development

项目摘要

Mount Sinai ADRC (Sano): OVERALL – Research Summary Alzheimer's disease (AD) is a major health threat to the nation and the world causing great human pain and economic loss. While some advances have been made in detection and raising awareness, finding treatments has remained unsuccessful in spite of decades of research. To date, efforts have focused on defining the disease by a narrow characterization of end-stage pathology, using restrictive samples and technologies that systematically exclude the diversity of the disease. This approach has led to multiple failures, resulting in scant progress on the therapeutic front. With this backdrop, the Mount Sinai Alzheimer's Disease Research Center (MSADRC), with its history of success in therapeutic development dedicates itself anew to identify and develop effective approaches to treating AD. Co-located in Manhattan on the Mount Sinai campus and in the Bronx at the James J Peters Veterans Administration Medical Center, we bring the strength of two premiere institutions to the mission of finding a treatment for AD. This application builds on these institutional strengths including systems- based approaches to scientific inquiry, using the computational tools to mine big data and our established expertise in recruiting diverse populations. We propose as our theme “Understanding disease heterogeneity to optimize therapeutic approaches to treat and cure Alzheimer's disease” as it aligns our strengths with the implementation areas and milestones of the National Alzheimer's Project Act (NAPA). We propose 7 cores (Administrative, Clinical, Biomarker, Genetics, Neuropathology, Data, and Outreach) and a Research Education Component, all of which have outstanding leadership reflecting newly recruited faculty as well investigators with established histories at the MSADRC. Using the collaborative efforts of the Clinical and Outreach Core, enhanced by novel methods of patient engagement through the electronic medical records at both locations, we propose to expand and maintain a cohort of 450 diverse individuals, 40% of whom will be from under-represented minorities, all receiving annual clinical evaluations, genetic analysis, and blood biomarker collection. The Genetics Core will collect genetics data on all, generate GWAS, and will obtain plasma samples for established biomarkers and proteomics on this diverse cohort. Our new Biomarker Core, supported by new philanthropy and existing research efforts will obtain structural and functional imaging on all patients, and molecular phenotyping with CSF biomarkers or molecular imaging on at least 50% of the cohort, capturing its full diversity. The Neuropathology Core, expanding collection beyond brain to other relevant tissues and body fluids obtained at autopsy, will allow the preparation of relevant brain regions for unbiased systematic sampling (stereology) and autopsy-derived specimens for iPS, multiomics, microbiome, and exosome studies. The Data Core, enhanced by the addition of the Senior Associate Dean for Scientific Computing and Data Science as Core Co-Leader, will expand the capacity to integrate and share the Core's resources to facilitate interdisciplinary collaborations and create an environment that fosters innovative approaches to finding treatments and cures.

西奈山ADRC (Sano)：总体-研究总结