Alzheimer's Disease Research Center Supplement for VA Collaboration

这是对西奈山阿尔茨海默病研究中心(MSADRC)的补充资金请求， Pi：Mary Sano，博士(P30 AG066514)，试验有效和可持续战略的新方法 增加招募和留住退伍军人参加阿尔茨海默病临床研究和 阿尔茨海默病相关痴呆(AD/ADRD)。此补充应用程序增强了以下几个目标 最近资助的亚洲发展与合作委员会。以多年在James J的MSADRC同一地点的经验为基础 彼得斯在布朗克斯区的VAMC，本附录建议将外展和招募扩大到认知健康 退伍军人和那些早期或轻微认知障碍的人，让他们参与关于痴呆症的研究 预防和及早发现疾病。这些人在初级保健中最常见的是 患者看护团队(PACT)。为了针对这些人，我们建议使用布朗克斯地区卫生 信息组织(RHIO)，纽约州认证的健康信息交易所，以识别那些 在该地区的其他卫生设施中也可以看到。此资源与数据分析团队在 JJPVAMC，目前已经确定了2700多名可能可以接触进行研究的人 参与。在初级保健的支持下，我们将联合向这一群体开展外展活动 访问退伍军人管理局，并邀请他们对AD/ADRD的临床研究感兴趣。我们会 创建一个研究协调(RC)团队，该团队将利用JJP VA老年研究的专业知识， 教育和临床中心(GRECC)与患者、护理人员和提供者建立联盟。一位老兵 和护理者研究咨询委员会将通过GRECC组建，以协助 编制和评价由以下机构编制的外联、参与和教育材料 ADRC的外联和接触(ORE)核心。理事会将为建设提供投入 在退伍军人社区中提高认知健康和痴呆症预防意识的信息 建议与退伍军人病患及其照顾者相关的讲座和研讨会的主题。 加入注册的参与者将被邀请参加自然历史和生物标记物等研究 研究包括MSADRC临床核心、临床试验、调查研究和教育机会 这将由MSADRC外联核心提供。RC团队将跟踪注册参与者以确定 成功招募的受试者概况和特定类型试验的招募比率。细节，如 联系、推荐、筛选、成功登记并保留到AD/ADRD的退伍军人人数 研究将被跟踪，数据将被用于评估和修改外展工作，以最大限度地提高退伍军人 投身于研究。作为结果，我们希望这项工作将改善AD/ADRD相关的招聘 侧重于疾病早期阶段和疾病预防工作的生物标志物研究的试验，以及 创建一个路线图，使成功能够在其他中心复制。

This is a request for supplemental funds to the Mount Sinai Alzheimer’s Disease Research Center (MSADRC), PI: Mary Sano, PhD, (P30 AG066514) to pilot novel approaches for effective and sustainable strategies to increase the recruitment and retention of veterans into clinical research studies of Alzheimer’s disease and Alzheimer's disease related dementias (AD/ADRD). This supplemental application enhances several aims of the recently funded ADRC. Building on years of experience with co-location of the MSADRC at the James J Peters VAMC in the Bronx, this supplement proposes to extend outreach and recruitment to cognitively healthy veterans and those with early or subtle cognitive impairment to engage them in research around dementia prevention and early detection of disease. These individuals are most often seen in primary care by the Patient Aligned Care Team (PACT). To target these individuals we propose to use the Bronx Regional Health Information Organization (RHIO), a New York State certified health information exchange, to identify those who are seen at other health facilities in the region. This resource, in combination with the data analytic team at the JJPVAMC, has currently identified over 2700 individuals who may be available to approach for research participation. With the support of primary care we will conduct outreach activities to this cohort in conjunction with their visits with the VA PACT, and invite them to register interest in clinical research in AD/ADRD. We will create a Research Coordination (RC) Team that will use the expertise of the JJP VA Geriatric Research, Education and Clinical Center (GRECC) to create alliances with patients, caregivers and providers. A Veteran and Caregiver Research Advisory Council will be assembled through the GRECC to assist with the development and evaluation of outreach, engagement and educational materials that have been developed by the Outreach and Engagement (ORE) core of the ADRC. The council will provide input for constructing messages to raise awareness of cognitive health and dementia prevention in the veteran community and will suggest topics for lectures and workshops that are relevant to concerns of VA patients and their caregivers. Participants who join the registry will be invited to participate in studies such as natural history and biomarker studies including into the MSADRC clinical Core, clinical trials, survey studies and educational opportunities that will be offered by the MSADRC Outreach Core. The RC team will track registry participants to determine the profile of successfully enrolled subjects and rates of recruitment into specific types of trials. Details such as the number of veterans contacted, referred, screened, successfully enrolled and retained in to AD/ADRD research will be tracked and the data will be used to evaluate and modify outreach efforts to maximize veteran engagement in research. As outcomes, we expect this work to improve recruitment into AD/ADRD related trials with a specific focus on biomarker studies for early disease stage and disease prevention efforts, and to create a roadmap that will permit the success to be reproduced in other centers.