Alzheimer's Disease Research Center Supplement for VA Collaboration

阿尔茨海默病研究中心 VA 合作补充资料

• 批准号: 10192271
• 负责人: Mary Sano
• 金额: $ 31.44万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10192271
• 关键词: Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Awareness; Biological Markers; Caregiver research; Caregivers; Caring; Clinic; Clinical; Clinical Research; Clinical Services; Clinical Trials; Cognitive; Collaborations; Communities; Data; Data Analytics; Data Sources; Dementia; Development; Disease; Doctor of Philosophy; Early Diagnosis; Education; Educational Materials; Educational workshop; Elderly; Eligibility Determination; Enrollment; Evaluation; Faculty; Funding; Geriatric Psychiatry; Geriatrics; Goals; Health; Health care facility; Impaired cognition; Individual; Investigational Therapies; Location; Medical; Medical center; Monitor; Natural History; New York; Outcome; Outreach Research; Participant; Patient Care; Patients; Population; Prevention; Primary Health Care; Provider; Recording of previous events; Records; Registries; Research; Resources; Schedule; Services; Surveys; Veterans; Visit; Work; care seeking; clinical biomarkers; clinical center; cohort; comorbidity; design; disease natural history; disorder prevention; education research; eligible participant; ethnic diversity; experience; human old age (65+); improved; information organization; interest; lectures; medical specialties; meetings; member; novel strategies; outreach; primary care services; racial and ethnic; ranpirnase; recruit; research study; success; tool

This is a request for supplemental funds to the Mount Sinai Alzheimer’s Disease Research Center (MSADRC), PI: Mary Sano, PhD, (P30 AG066514) to pilot novel approaches for effective and sustainable strategies to increase the recruitment and retention of veterans into clinical research studies of Alzheimer’s disease and Alzheimer's disease related dementias (AD/ADRD). This supplemental application enhances several aims of the recently funded ADRC. Building on years of experience with co-location of the MSADRC at the James J Peters VAMC in the Bronx, this supplement proposes to extend outreach and recruitment to cognitively healthy veterans and those with early or subtle cognitive impairment to engage them in research around dementia prevention and early detection of disease. These individuals are most often seen in primary care by the Patient Aligned Care Team (PACT). To target these individuals we propose to use the Bronx Regional Health Information Organization (RHIO), a New York State certified health information exchange, to identify those who are seen at other health facilities in the region. This resource, in combination with the data analytic team at the JJPVAMC, has currently identified over 2700 individuals who may be available to approach for research participation. With the support of primary care we will conduct outreach activities to this cohort in conjunction with their visits with the VA PACT, and invite them to register interest in clinical research in AD/ADRD. We will create a Research Coordination (RC) Team that will use the expertise of the JJP VA Geriatric Research, Education and Clinical Center (GRECC) to create alliances with patients, caregivers and providers. A Veteran and Caregiver Research Advisory Council will be assembled through the GRECC to assist with the development and evaluation of outreach, engagement and educational materials that have been developed by the Outreach and Engagement (ORE) core of the ADRC. The council will provide input for constructing messages to raise awareness of cognitive health and dementia prevention in the veteran community and will suggest topics for lectures and workshops that are relevant to concerns of VA patients and their caregivers. Participants who join the registry will be invited to participate in studies such as natural history and biomarker studies including into the MSADRC clinical Core, clinical trials, survey studies and educational opportunities that will be offered by the MSADRC Outreach Core. The RC team will track registry participants to determine the profile of successfully enrolled subjects and rates of recruitment into specific types of trials. Details such as the number of veterans contacted, referred, screened, successfully enrolled and retained in to AD/ADRD research will be tracked and the data will be used to evaluate and modify outreach efforts to maximize veteran engagement in research. As outcomes, we expect this work to improve recruitment into AD/ADRD related trials with a specific focus on biomarker studies for early disease stage and disease prevention efforts, and to create a roadmap that will permit the success to be reproduced in other centers.

这是对西奈山阿尔茨海默病研究中心（MSADRC）补充资金的请求， PI：玛丽佐野，博士，（P30 AG 066514）试点有效和可持续的战略， 增加招募和保留退伍军人参加阿尔茨海默病的临床研究， 阿尔茨海默病相关性痴呆（AD/ADRD）。该补充申请增强了以下几个目的： 最近获得资助的ADRC。凭借多年来在詹姆斯·J·詹姆斯大学与MSADRC合署办公的经验， 彼得斯VAMC在布朗克斯，这一补充建议，扩大推广和招聘，以认知健康 退伍军人和那些有早期或轻微认知障碍的人，让他们参与痴呆症的研究 预防和早期发现疾病。这些人最常见于初级保健， Patient Aligned Care Team（PACT）针对这些人，我们建议使用布朗克斯地区卫生部 信息组织（RHIO），一个纽约州认证的健康信息交换机构， 在该地区的其他医疗机构也可以看到。该资源与 JJPVAMC目前已经确定了2700多名可以进行研究的人 参与的在初级保健的支持下，我们将与 与他们的访问与VA PACT，并邀请他们登记在AD/ADRD的临床研究的兴趣。我们将 创建一个研究协调（RC）团队，该团队将利用JJP VA老年研究的专业知识， 教育和临床中心（GRECC）与患者，护理人员和提供者建立联盟。一位资深 和护理人员研究咨询理事会将通过GRECC进行组装，以协助 * 编制和评价各机构编制的外联、参与和教育材料 “外展和参与”（ORE）是ADRC的核心。理事会将为建设 信息，以提高认知健康和老年痴呆症的预防意识，在退伍军人社区， 建议与VA患者及其护理人员关注的问题相关的讲座和研讨会的主题。 加入登记研究的受试者将被邀请参加自然史和生物标志物等研究 研究，包括进入MSADRC临床核心，临床试验，调查研究和教育机会 将由MSADRC外展核心提供。RC团队将跟踪登记研究参与者，以确定 成功入组受试者的概况和特定类型试验的招募率。等细节 联系、转介、筛选、成功登记和保留到AD/ADRD的退伍军人人数 研究将被跟踪，数据将用于评估和修改外展工作，以最大限度地提高退伍军人 参与研究。作为结果，我们希望这项工作能够改善AD/ADRD相关的招募工作。 特别关注早期疾病阶段和疾病预防工作的生物标志物研究的试验， 创建一个路线图，使成功能够在其他中心复制。