Dynamic Mechanisms of Membrane Channel Gating by CryoEM

CryoEM 膜通道门控的动态机制

基本信息

  • 批准号:
    10406779
  • 负责人:
  • 金额:
    $ 9.38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-08-15 至 2022-12-31
  • 项目状态:
    已结题

项目摘要

Project Summary Pore-forming membrane channels are central mediators of many complex biological phenomena; such as synchronizing the contraction of our heart and electro-chemical signals in our brain, and detecting light, sound, touch, taste and smells of the world around us. This ability is dependent upon dynamic mechanism used to spatially and temporally modulate their cellular activity. Our research group is focused on understanding how these types of phenomena are choreographed by remarkably complex strategies of cell-to-cell communication, through the gap junctions. We aim to develop a molecular and atomic-level of mechanistic understanding of how gap junctions coordinate inter-cellular communication. To achieve this level of detail, we are combining the unique power of electron cryo-microscopy (CryoEM), together with computational modeling and targeted biophysical and functional studies to address several fundamental questions, such as: i) How do the gap junctions selectively control the flow of chemical information between cells? ii) How are their activities allosterically modulated by physiological signals and pharmacological agents? iii) How gap junction assembly, structure and function is coupled with the local lipid/cellular environment? Despite their physiological and medical relevance, membrane proteins still only represent ~4% of the protein structure database. However, recent advances in the field of high-resolution CryoEM, coupled with advancements in membrane protein biochemistry and in situ imaging technologies, are beginning to revolutionize the way we structurally characterize these proteins. With these tools in hand, we are addressing several key questions about gap junction assembly, selectivity and regulation. The results of our investigations are expected to provide an architectural framework and the mechanistic knowledge required for the rational development of targeted therapies against a range of gap junction related diseases, such as blindness, deafness, arrhythmia, stroke and cancers.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Stephen Loen Reichow其他文献

Stephen Loen Reichow的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Stephen Loen Reichow', 18)}}的其他基金

Structure, function and aggregation of lens α-crystallins by CryoEM
CryoEM 晶状体α-晶状体蛋白的结构、功能和聚集
  • 批准号:
    10089452
  • 财政年份:
    2020
  • 资助金额:
    $ 9.38万
  • 项目类别:
Structure, function and aggregation of lens α-crystallins by CryoEM
CryoEM 晶状体α-晶状体蛋白的结构、功能和聚集
  • 批准号:
    10363616
  • 财政年份:
    2020
  • 资助金额:
    $ 9.38万
  • 项目类别:
Structure, function and aggregation of lens α-crystallins by CryoEM
CryoEM 晶状体α-晶状体蛋白的结构、功能和聚集
  • 批准号:
    10876690
  • 财政年份:
    2020
  • 资助金额:
    $ 9.38万
  • 项目类别:
Dynamic Mechanisms of Membrane Channel Gating by CryoEM
CryoEM 膜通道门控的动态机制
  • 批准号:
    10687015
  • 财政年份:
    2017
  • 资助金额:
    $ 9.38万
  • 项目类别:
Dynamic Mechanisms of Membrane Channel Gating by CryoEM
CryoEM 膜通道门控的动态机制
  • 批准号:
    9381650
  • 财政年份:
    2017
  • 资助金额:
    $ 9.38万
  • 项目类别:
Dynamic Mechanisms of Membrane Channel Gating by CryoEM
CryoEM 膜通道门控的动态机制
  • 批准号:
    10244881
  • 财政年份:
    2017
  • 资助金额:
    $ 9.38万
  • 项目类别:
CRYSTALLOGRAPHIC STUDIES OF THE AQP0-CAM COMPLEX
AQP0-CAM 复合体的晶体学研究
  • 批准号:
    8362162
  • 财政年份:
    2011
  • 资助金额:
    $ 9.38万
  • 项目类别:
CRYSTALLOGRAPHIC STUDIES OF THE AQP0-CAM COMPLEX
AQP0-CAM 复合体的晶体学研究
  • 批准号:
    8170113
  • 财政年份:
    2010
  • 资助金额:
    $ 9.38万
  • 项目类别:
CRYSTALLOGRAPHIC STUDIES OF THE AQP0-CAM COMPLEX
AQP0-CAM 复合体的晶体学研究
  • 批准号:
    7954443
  • 财政年份:
    2009
  • 资助金额:
    $ 9.38万
  • 项目类别:
Electron crystallographic studies of water channel regulation
水通道调节的电子晶体学研究
  • 批准号:
    7611345
  • 财政年份:
    2009
  • 资助金额:
    $ 9.38万
  • 项目类别:

相似海外基金

CAREER: Efficient Algorithms for Modern Computer Architecture
职业:现代计算机架构的高效算法
  • 批准号:
    2339310
  • 财政年份:
    2024
  • 资助金额:
    $ 9.38万
  • 项目类别:
    Continuing Grant
Hardware-aware Network Architecture Search under ML Training workloads
ML 训练工作负载下的硬件感知网络架构搜索
  • 批准号:
    2904511
  • 财政年份:
    2024
  • 资助金额:
    $ 9.38万
  • 项目类别:
    Studentship
CAREER: Creating Tough, Sustainable Materials Using Fracture Size-Effects and Architecture
职业:利用断裂尺寸效应和架构创造坚韧、可持续的材料
  • 批准号:
    2339197
  • 财政年份:
    2024
  • 资助金额:
    $ 9.38万
  • 项目类别:
    Standard Grant
Travel: Student Travel Support for the 51st International Symposium on Computer Architecture (ISCA)
旅行:第 51 届计算机体系结构国际研讨会 (ISCA) 的学生旅行支持
  • 批准号:
    2409279
  • 财政年份:
    2024
  • 资助金额:
    $ 9.38万
  • 项目类别:
    Standard Grant
Understanding Architecture Hierarchy of Polymer Networks to Control Mechanical Responses
了解聚合物网络的架构层次结构以控制机械响应
  • 批准号:
    2419386
  • 财政年份:
    2024
  • 资助金额:
    $ 9.38万
  • 项目类别:
    Standard Grant
I-Corps: Highly Scalable Differential Power Processing Architecture
I-Corps:高度可扩展的差分电源处理架构
  • 批准号:
    2348571
  • 财政年份:
    2024
  • 资助金额:
    $ 9.38万
  • 项目类别:
    Standard Grant
Collaborative Research: Merging Human Creativity with Computational Intelligence for the Design of Next Generation Responsive Architecture
协作研究:将人类创造力与计算智能相结合,设计下一代响应式架构
  • 批准号:
    2329759
  • 财政年份:
    2024
  • 资助金额:
    $ 9.38万
  • 项目类别:
    Standard Grant
The architecture and evolution of host control in a microbial symbiosis
微生物共生中宿主控制的结构和进化
  • 批准号:
    BB/X014657/1
  • 财政年份:
    2024
  • 资助金额:
    $ 9.38万
  • 项目类别:
    Research Grant
RACCTURK: Rock-cut Architecture and Christian Communities in Turkey, from Antiquity to 1923
RACCTURK:土耳其的岩石建筑和基督教社区,从古代到 1923 年
  • 批准号:
    EP/Y028120/1
  • 财政年份:
    2024
  • 资助金额:
    $ 9.38万
  • 项目类别:
    Fellowship
NSF Convergence Accelerator Track M: Bio-Inspired Surface Design for High Performance Mechanical Tracking Solar Collection Skins in Architecture
NSF Convergence Accelerator Track M:建筑中高性能机械跟踪太阳能收集表皮的仿生表面设计
  • 批准号:
    2344424
  • 财政年份:
    2024
  • 资助金额:
    $ 9.38万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了