Promoting Physical Activity to Improve Cognitive Function in Older Adults Undergoing Hematopoietic Cell Transplantation (HCT)
促进身体活动以改善接受造血细胞移植 (HCT) 的老年人的认知功能
基本信息
- 批准号:10298917
- 负责人:
- 金额:$ 19.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdoptionAdultAffectAgeAge-YearsAttentionBehavioral SciencesBrainCancer SurvivorCancer SurvivorshipChronicClinicalCognitionCognition DisordersCognitive agingCollaborationsCommunitiesCommunity HealthDataDissemination and ImplementationDistressEffectivenessElderlyEvaluationExerciseExercise TestFeedbackFutureGeriatricsGuidelinesHealthHematologic NeoplasmsHospitalizationImmune systemImmunosuppressionImpaired cognitionIndividualInflammationInfusion proceduresInterventionInterviewK-Series Research Career ProgramsKnowledgeLeadershipLifeLightMalignant NeoplasmsMeasuresMemoryMentorsMentorshipMethodsModelingNeuropsychological TestsOncologyOutcomePathway interactionsPatient CarePatientsPerceptionPerformancePhysical FunctionPhysical activityPopulationPositioning AttributeProcessQuality of lifeRadiation therapyReach, Effectiveness, Adoption, Implementation, and MaintenanceResearchResearch PersonnelRiskRoleSeveritiesStructureSurvivorsTarget PopulationsTestingToxic effectTrainingTranslationsTransplant RecipientsTransplantationVulnerable PopulationsWorkactive controlbasecancer therapycardiorespiratory fitnesschemotherapyclinical practiceclinical trial implementationcognitive benefitscognitive changecognitive functioncollaborative approachdesigndisabilityeffectiveness evaluationeffectiveness implementation designeffectiveness implementation studyeffectiveness researchevidence baseexecutive functionexercise interventionexercise trainingexperiencefunctional outcomeshematopoietic cell transplantationhigh riskimplementation determinantsimplementation interventionimplementation researchimplementation scienceimplementation strategyimprovedinnovationmembernovelolder patientpreservationpreventprimary outcomeprogramssecondary outcomesedentary activityskillsstem cellstranslational studytrial design
项目摘要
PROJECT SUMMARY
Cancer and treatment-related cognitive changes cause distress, hinder resumption of normal routine and roles,
and worsen quality of life. Hematopoietic cell transplantation (HCT) is a potentially life-prolonging treatment for
patients with hematological malignancies. HCT differs from the delivery of chemotherapy in other cancer settings
due to the intensity of chemotherapy and severity of toxicity. Previously reserved for younger patients, in the past
decade a growing number of adults 60 years of age and older have received this intense treatment. Our
preliminary data shows that post-HCT, 35% of older patients experience significant cognitive impairment
compared to 19% pre-HCT. Physical activity improves cognitive function in older adults and survivors of other
cancers. While untested in older adults undergoing HCT, we hypothesize that increasing physical activity can
also improve cognitive function in this vulnerable population. The objective of this proposal is to adapt and test
an evidence-based physical activity intervention, The Community Health Activities Model Program for Seniors II
(CHAMPS II), in the HCT setting to improve cognitive function for adults 60 years and older. This program is
effective in increasing physical activity for sedentary community-dwelling older adults with multiple chronic health
conditions. We will iteratively adapt and implement CHAMPS-II in three waves. During each wave, 2-4
patient/care-partner dyads will participate in a multi-phase, light- to moderate-intensity physical activity program.
We will use a Type 1 hybrid effectiveness-implementation design to determine the preliminary effectiveness of
the adapted intervention to improve cognitive function compared to an active control condition (N = 34 per group).
This novel trial design spans the effectiveness and implementation research to accelerate the translation of
physical activity interventions into practice for older adults with cancer. The translation of physical activity
interventions into clinical practice remains challenging within cancer survivorship, despite promising evidence of
efficacy in improving functional outcomes and quality of life. To become an independent researcher who
develops, implements, and disseminates interventions that prevent cognitive decline and improve functional
outcomes for older patients with cancer, Dr. Koll requires additional training and experience in: 1) physical activity
promotion and principles of exercise training; 2) design and conduct of hybrid effectiveness-implementation
clinical trials; and 3) leadership and project management skills needed to execute translational studies requiring
collaboration between researchers and clinicians. An outstanding team of mentors and advisors support this
proposal with expertise in geriatrics (Fisher), behavioral and implementation science (Estabrooks), clinical
exercise trials in older adult and cancer populations (Ehlers), geriatric oncology (Wildes), cognitive disorders and
cognitive aging (Murman), and mixed methods (Jones). The training and research plan will position Dr. Koll to
become one of the few geriatricians with expertise in cognition and cognition-enhancing interventions in older
adults with cancer.
项目概要
癌症和治疗相关的认知变化会导致痛苦,阻碍正常生活和角色的恢复,
并恶化生活质量。造血细胞移植(HCT)是一种潜在的延长生命的治疗方法
患有血液系统恶性肿瘤的患者。 HCT 不同于其他癌症环境中的化疗
由于化疗的强度和毒性的严重程度。过去是为年轻患者保留的
十年来,越来越多的 60 岁及以上成年人接受了这种强化治疗。我们的
初步数据显示,HCT 后,35% 的老年患者出现明显的认知障碍
相比之下,HCT 前为 19%。体育活动可以改善老年人和其他幸存者的认知功能
癌症。虽然未经在接受 HCT 的老年人中进行测试,但我们假设增加体力活动可以
还可以改善这一弱势群体的认知功能。该提案的目的是适应和测试
基于证据的身体活动干预措施,老年人社区健康活动模式计划 II
(CHAMPS II),在 HCT 环境中改善 60 岁及以上成年人的认知功能。这个程序是
有效增加患有多种慢性病的社区久坐老年人的身体活动
状况。我们将分三波迭代调整和实施CHAMPS-II。每波期间,2-4
患者/护理伙伴二人组将参加多阶段、轻至中等强度的身体活动计划。
我们将使用类型 1 混合有效性实施设计来确定以下项目的初步有效性:
与主动控制条件相比,调整后的干预措施可改善认知功能(每组 N = 34)。
这种新颖的试验设计涵盖了有效性和实施研究,以加速转化
对患有癌症的老年人进行身体活动干预。身体活动的翻译
尽管有希望的证据表明,在癌症生存方面对临床实践进行干预仍然具有挑战性
改善功能结果和生活质量的功效。成为一名独立研究员
制定、实施和传播预防认知能力下降和改善功能的干预措施
对于老年癌症患者的结果,科尔博士需要额外的培训和经验:1)身体活动
运动训练的推广及原则; 2)混合有效性实施的设计和实施
临床试验; 3) 执行转化研究所需的领导和项目管理技能
研究人员和临床医生之间的合作。优秀的导师和顾问团队为此提供支持
具有老年病学(Fisher)、行为和实施科学(Estabrooks)、临床专业知识的提案
老年人和癌症人群的运动试验(Ehlers)、老年肿瘤学(Wildes)、认知障碍和
认知老化(Murman)和混合方法(Jones)。培训和研究计划将使科尔博士能够
成为少数在老年人认知和认知增强干预方面拥有专业知识的老年科医生之一
患有癌症的成年人。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thuy Koll其他文献
Thuy Koll的其他文献
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{{ truncateString('Thuy Koll', 18)}}的其他基金
Promoting Physical Activity to Improve Cognitive Function in Older Adults Undergoing Hematopoietic Cell Transplantation (HCT)
促进身体活动以改善接受造血细胞移植 (HCT) 的老年人的认知功能
- 批准号:
10697347 - 财政年份:2021
- 资助金额:
$ 19.02万 - 项目类别:
Promoting Physical Activity to Improve Cognitive Function in Older Adults Undergoing Hematopoietic Cell Transplantation (HCT)
促进身体活动以改善接受造血细胞移植 (HCT) 的老年人的认知功能
- 批准号:
10491901 - 财政年份:2021
- 资助金额:
$ 19.02万 - 项目类别:
An Expanded Framework to Measure Cognitive Function in Older Adults Undergoing Hematopoietic Cell Transplantation
测量接受造血细胞移植的老年人认知功能的扩展框架
- 批准号:
9812006 - 财政年份:2019
- 资助金额:
$ 19.02万 - 项目类别:
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