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Alcohol consumption and related comorbid conditions: health state utilities for economic evaluation

酒精消费和相关合并症：用于经济评估的健康状况公用事业

基本信息

批准号：
10426403
负责人：
JEREMY W BRAY
金额：
$ 8.21万
依托单位：
UNIVERSITY OF NORTH CAROLINA GREENSBORO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-05 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10426403
关键词：
Abstinence Academic Research Enhancement Awards Address Aftercare Alcohol consumption Alcoholism Alcohols Algorithms Asthma Cessation of life Collaborations Communities Consumption Cost Effectiveness Analysis Cost utility DSM-V Data Data Analyses Data Set Decision Making Development Disadvantaged Disease Economics Epidemiology Exposure to Fostering Foundations General Population Goals Health Health Services Health Services Research Health Status Health Technology Healthcare Individual International Intervention Joints Journals Lead Life Measures Medical Methods North Carolina Outcome Outcome Measure Patient Outcomes Assessments Patient-Centered Care Patients Pharmaceutical Preparations Play Policies Policy Research Population Prevention Public Health Public Health Schools Quality of life Quality-Adjusted Life Years Recommendation Registries Research Research Personnel Resource Allocation Resources Risk Sampling Severities Societies Source Surveys Testing Time Training United States Universities Weight World Health Organization addiction alcohol abuse therapy alcohol and other drug alcohol research alcohol services alcohol use disorder arthropathies base brief alcohol intervention care outcomes clinical decision-making clinical practice comorbidity comparative cost cost effectiveness design and construction digital drinking economic evaluation effective therapy experience graduate student improved member patient population performance tests population health prediction algorithm predictive test preference programs repository symposium undergraduate student

项目摘要

PROJECT SUMMARY Effective prevention and treatment of alcohol use disorder (AUD) in the US could save more than 80,000 lives each year. Although abstinence has traditionally been the goal of AUD interventions, reductions in drinking levels have been shown to decrease the harms of AUD, providing an additional “goal post” for prevention and treatment. At the same time, patient-centered care and patient-reported outcomes are having a greater impact on health care decision-making than ever before. Thus, there is an urgent need for rigorous alcohol health services research to inform practice and policy. Moreover, it is critical that this research parallel medically-focused health services research to solidify a “level playing field” in comparative assessments for resource allocation decisions. Increasingly these resource allocation decisions are informed by cost-effectiveness analyses that use health utility as an outcome. Health utility captures individuals’ preferences for living in a given health state and is the foundation of quality adjusted life years (QALYs), the preferred outcome measure for cost-effectiveness analysis. Health utilities and QALYs are rarely used by alcohol health services researchers, however. The lack of health utilities for alcohol health states is a critical shortcoming in alcohol health services research that disadvantages alcohol services in resource allocation decisions. To promote the use of health utilities in alcohol health services research, we will conduct secondary data analyses of the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III) to address the following specific aims: Aim 1: Estimate health state utilities for AUD health states stratified by alcohol consumption levels. 1.1 Estimate mean utility and variance for AUD health states based on DSM-5 severity and WHO risk levels. 1.2 Test utility differences between adjacent health states to inform the impact of reductions in AUD severity and/or consumption levels. Aim 2: Empirically and predictively derive joint health state utilities for AUD with comorbid conditions. 2.1 Estimate mean utility and variance for past year AUD with select comorbid conditions. 2.2 Test the performance of predictive algorithms for estimating joint health state utilities in AUD. As an AREA project, we will involve graduate and undergraduate students in all aspects of the study as integral members of the research team, providing intensive exposure to and training in research. We will disseminate our results to the clinical, practice, policy, and research communities to advance the use of health utility in alcohol health services research. Our findings will result in broader use of health utilities and QALYs for policy and clinical decision making in alcohol health services, and thereby lead to improved patient and population health. 1

项目概要在美国，有效预防和治疗酒精使用障碍 (AUD) 可以挽救超过 80,000 人的生命每年都活着。尽管禁欲传统上一直是 AUD 干预措施的目标，但减少饮酒水平已被证明可以减少 AUD 的危害，为预防和治疗。与此同时，以患者为中心的护理和患者报告的结果正在产生影响对医疗保健决策的影响比以往任何时候都更大。因此，迫切需要严格的 alcohol health services research to inform practice and policy.此外，至关重要的是，这项研究与以医疗为重点的卫生服务研究，以巩固比较评估中的“公平竞争环境” 资源分配决策。这些资源分配决策越来越多地通过成本效益分析得出，这些分析使用健康效用作为结果。健康效用捕捉个人对特定健康状态下生活的偏好，是质量调整生命年 (QALY) 的基础，是成本效益的首选结果衡量标准分析。然而，酒精健康服务研究人员很少使用健康实用程序和 QALY。缺乏酒精健康状况的健康公用事业是酒精健康服务研究的一个严重缺陷酒精服务在资源分配决策中处于劣势。为了促进健康公用事业在酒精健康服务研究中的使用，我们将进行二手数据对国家酒精及相关病症流行病学调查 III (NESARC-III) 的分析，以解决具体目标如下：目标 1：估计按酒精消费水平分层的澳元健康状况的健康状况效用。 1.1 根据 DSM-5 严重程度和 WHO 风险水平估计 AUD 健康状况的平均效用和方差。 1.2 测试相邻健康状态之间的效用差异，以了解 AUD 严重程度降低的影响和/或消费水平。目标 2：根据经验和预测得出 AUD 与合并症的联合健康状态效用。 2.1 估计过去一年澳元在选定合并症情况下的平均效用和方差。 2.2 测试用于估计关节健康状态效用的预测算法的性能（以 AUD 为单位）。作为 AREA 项目，我们将让研究生和本科生参与研究的各个方面研究团队的重要成员，提供深入的研究接触和培训。我们将将我们的结果传播给临床、实践、政策和研究界，以促进健康的利用在酒精健康服务研究中的实用性。我们的研究结果将导致卫生设施和 QALY 的更广泛使用促进酒精健康服务的政策和临床决策，从而改善患者和人口健康。 1

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Association of opioid utilization management with prescribing and overdose.

DOI：
10.37765/ajmc.2022.88829
发表时间：
2022-02-01
期刊：
The American journal of managed care
影响因子：
0
作者：
Andersen MS;Lorenz V;Pant A;Bray JW;Alexander GC
通讯作者：
Alexander GC

Estimating Joint Health State Utility Algorithms Under Partial Information.

DOI：
10.1016/j.jval.2022.09.009
发表时间：
2023-05
期刊：
VALUE IN HEALTH
影响因子：
4.5
作者：
Bray, Jeremy W.;Thornburg, Benjamin D.;Gebreselassie, Abraham W.;LaButte, Collin A.;Barbosa, Carolina;Wittenberg, Eve
通讯作者：
Wittenberg, Eve

Health Utility of Drinkers' Family Members: A Secondary Analysis of a US Population Data Set.