Alcohol consumption and related comorbid conditions: health state utilities for economic evaluation
酒精消费和相关合并症:用于经济评估的健康状况公用事业
基本信息
- 批准号:10426403
- 负责人:
- 金额:$ 8.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-05 至 2022-11-30
- 项目状态:已结题
- 来源:
- 关键词:AbstinenceAcademic Research Enhancement AwardsAddressAftercareAlcohol consumptionAlcoholismAlcoholsAlgorithmsAsthmaCessation of lifeCollaborationsCommunitiesConsumptionCost Effectiveness AnalysisCost utilityDSM-VDataData AnalysesData SetDecision MakingDevelopmentDisadvantagedDiseaseEconomicsEpidemiologyExposure toFosteringFoundationsGeneral PopulationGoalsHealthHealth ServicesHealth Services ResearchHealth StatusHealth TechnologyHealthcareIndividualInternationalInterventionJointsJournalsLeadLifeMeasuresMedicalMethodsNorth CarolinaOutcomeOutcome MeasurePatient Outcomes AssessmentsPatient-Centered CarePatientsPharmaceutical PreparationsPlayPoliciesPolicy ResearchPopulationPreventionPublic HealthPublic Health SchoolsQuality of lifeQuality-Adjusted Life YearsRecommendationRegistriesResearchResearch PersonnelResource AllocationResourcesRiskSamplingSeveritiesSocietiesSourceSurveysTestingTimeTrainingUnited StatesUniversitiesWeightWorld Health Organizationaddictionalcohol abuse therapyalcohol and other drugalcohol researchalcohol servicesalcohol use disorderarthropathiesbasebrief alcohol interventioncare outcomesclinical decision-makingclinical practicecomorbiditycomparativecostcost effectivenessdesign and constructiondigitaldrinkingeconomic evaluationeffective therapyexperiencegraduate studentimprovedmemberpatient populationperformance testspopulation healthprediction algorithmpredictive testpreferenceprogramsrepositorysymposiumundergraduate student
项目摘要
PROJECT SUMMARY
Effective prevention and treatment of alcohol use disorder (AUD) in the US could save more than 80,000
lives each year. Although abstinence has traditionally been the goal of AUD interventions, reductions in
drinking levels have been shown to decrease the harms of AUD, providing an additional “goal post” for
prevention and treatment. At the same time, patient-centered care and patient-reported outcomes are having a
greater impact on health care decision-making than ever before. Thus, there is an urgent need for rigorous
alcohol health services research to inform practice and policy. Moreover, it is critical that this research parallel
medically-focused health services research to solidify a “level playing field” in comparative assessments for
resource allocation decisions.
Increasingly these resource allocation decisions are informed by cost-effectiveness analyses that use
health utility as an outcome. Health utility captures individuals’ preferences for living in a given health state and
is the foundation of quality adjusted life years (QALYs), the preferred outcome measure for cost-effectiveness
analysis. Health utilities and QALYs are rarely used by alcohol health services researchers, however. The lack
of health utilities for alcohol health states is a critical shortcoming in alcohol health services research that
disadvantages alcohol services in resource allocation decisions.
To promote the use of health utilities in alcohol health services research, we will conduct secondary data
analyses of the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III) to address
the following specific aims:
Aim 1: Estimate health state utilities for AUD health states stratified by alcohol consumption levels.
1.1 Estimate mean utility and variance for AUD health states based on DSM-5 severity and WHO risk levels.
1.2 Test utility differences between adjacent health states to inform the impact of reductions in AUD severity
and/or consumption levels.
Aim 2: Empirically and predictively derive joint health state utilities for AUD with comorbid conditions.
2.1 Estimate mean utility and variance for past year AUD with select comorbid conditions.
2.2 Test the performance of predictive algorithms for estimating joint health state utilities in AUD.
As an AREA project, we will involve graduate and undergraduate students in all aspects of the study as
integral members of the research team, providing intensive exposure to and training in research. We will
disseminate our results to the clinical, practice, policy, and research communities to advance the use of health
utility in alcohol health services research. Our findings will result in broader use of health utilities and QALYs
for policy and clinical decision making in alcohol health services, and thereby lead to improved patient and
population health.
1
项目概要
在美国,有效预防和治疗酒精使用障碍 (AUD) 可以挽救超过 80,000 人的生命
每年都活着。尽管禁欲传统上一直是 AUD 干预措施的目标,但减少
饮酒水平已被证明可以减少 AUD 的危害,为
预防和治疗。与此同时,以患者为中心的护理和患者报告的结果正在产生影响
对医疗保健决策的影响比以往任何时候都更大。因此,迫切需要严格的
alcohol health services research to inform practice and policy.此外,至关重要的是,这项研究与
以医疗为重点的卫生服务研究,以巩固比较评估中的“公平竞争环境”
资源分配决策。
这些资源分配决策越来越多地通过成本效益分析得出,这些分析使用
健康效用作为结果。健康效用捕捉个人对特定健康状态下生活的偏好,
是质量调整生命年 (QALY) 的基础,是成本效益的首选结果衡量标准
分析。然而,酒精健康服务研究人员很少使用健康实用程序和 QALY。缺乏
酒精健康状况的健康公用事业是酒精健康服务研究的一个严重缺陷
酒精服务在资源分配决策中处于劣势。
为了促进健康公用事业在酒精健康服务研究中的使用,我们将进行二手数据
对国家酒精及相关病症流行病学调查 III (NESARC-III) 的分析,以解决
具体目标如下:
目标 1:估计按酒精消费水平分层的澳元健康状况的健康状况效用。
1.1 根据 DSM-5 严重程度和 WHO 风险水平估计 AUD 健康状况的平均效用和方差。
1.2 测试相邻健康状态之间的效用差异,以了解 AUD 严重程度降低的影响
和/或消费水平。
目标 2:根据经验和预测得出 AUD 与合并症的联合健康状态效用。
2.1 估计过去一年澳元在选定合并症情况下的平均效用和方差。
2.2 测试用于估计关节健康状态效用的预测算法的性能(以 AUD 为单位)。
作为 AREA 项目,我们将让研究生和本科生参与研究的各个方面
研究团队的重要成员,提供深入的研究接触和培训。我们将
将我们的结果传播给临床、实践、政策和研究界,以促进健康的利用
在酒精健康服务研究中的实用性。我们的研究结果将导致卫生设施和 QALY 的更广泛使用
促进酒精健康服务的政策和临床决策,从而改善患者和
人口健康。
1
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association of opioid utilization management with prescribing and overdose.
- DOI:10.37765/ajmc.2022.88829
- 发表时间:2022-02-01
- 期刊:
- 影响因子:0
- 作者:Andersen MS;Lorenz V;Pant A;Bray JW;Alexander GC
- 通讯作者:Alexander GC
Estimating Joint Health State Utility Algorithms Under Partial Information.
- DOI:10.1016/j.jval.2022.09.009
- 发表时间:2023-05
- 期刊:
- 影响因子:4.5
- 作者:Bray, Jeremy W.;Thornburg, Benjamin D.;Gebreselassie, Abraham W.;LaButte, Collin A.;Barbosa, Carolina;Wittenberg, Eve
- 通讯作者:Wittenberg, Eve
Health Utility of Drinkers' Family Members: A Secondary Analysis of a US Population Data Set.
- DOI:10.1177/23814683221128507
- 发表时间:2022-07
- 期刊:
- 影响因子:0
- 作者:Thornburg, Benjamin;Bray, Jeremy W.;Wittenberg, Eve
- 通讯作者:Wittenberg, Eve
Alcohol consumption and health-related quality of life in the US during the COVID-19 pandemic: a US national survey.
- DOI:10.1186/s41687-022-00516-0
- 发表时间:2022-10-10
- 期刊:
- 影响因子:2.7
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JEREMY W BRAY其他文献
JEREMY W BRAY的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JEREMY W BRAY', 18)}}的其他基金
Alcohol consumption and related comorbid conditions: health state utilities for economic evaluation in the context of the COVID-19 pandemic
酒精消费和相关合并症:在 COVID-19 大流行背景下进行经济评估的健康状况公用事业
- 批准号:
10193124 - 财政年份:2019
- 资助金额:
$ 8.21万 - 项目类别:
Data Coordinating Center for the Work, Family and Health Network
工作、家庭和健康网络数据协调中心
- 批准号:
7562831 - 财政年份:2005
- 资助金额:
$ 8.21万 - 项目类别:
Data Coordinating Center for the Work, Family and Health Network
工作、家庭和健康网络数据协调中心
- 批准号:
7769903 - 财政年份:2005
- 资助金额:
$ 8.21万 - 项目类别:
Workplace Policies and Practices Coordinating Center
工作场所政策和实践协调中心
- 批准号:
7105494 - 财政年份:2005
- 资助金额:
$ 8.21万 - 项目类别:
Workplace Policies and Practices Coordinating Center
工作场所政策和实践协调中心
- 批准号:
7691675 - 财政年份:2005
- 资助金额:
$ 8.21万 - 项目类别:
Data Coordinating Center for the Work, Family and Health Network
工作、家庭和健康网络数据协调中心
- 批准号:
8046415 - 财政年份:2005
- 资助金额:
$ 8.21万 - 项目类别:
Workplace Policies and Practices Coordinating Center
工作场所政策和实践协调中心
- 批准号:
7280285 - 财政年份:2005
- 资助金额:
$ 8.21万 - 项目类别:
Data Coordinating Center for the Work, Family and Health Network
工作、家庭和健康网络数据协调中心
- 批准号:
8220985 - 财政年份:2005
- 资助金额:
$ 8.21万 - 项目类别:
Workplace Policies and Practices Coordinating Center
工作场所政策和实践协调中心
- 批准号:
7003618 - 财政年份:2005
- 资助金额:
$ 8.21万 - 项目类别:
Alcohol Screening and Brief Intervention in an EAP
EAP 中的酒精筛查和简短干预
- 批准号:
6827643 - 财政年份:2004
- 资助金额:
$ 8.21万 - 项目类别: