Marital quality and longevity: Biobehavioral pathways

婚姻质量和寿命：生物行为途径

• 批准号: 10415278
• 负责人: JANICE KIECOLT-GLASER
• 金额: $ 12.07万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415278
• 关键词: Address; Adult; Age; Aging; Behavior; Behavioral; Bioinformatics; Biological; Biological Assay; Biological Markers; Blood specimen; Budgets; CDKN2A gene; Code; Couples; DNA Methylation; Data; Data Analyses; Disclosure; Disease; Distress; Epigenetic Process; Event; Funding; Gender; Grant; Health; Health Benefit; Hostility; Immunologics; Individual; Inflammation; Inflammatory; Influentials; Length; Literature; Longevity; Marriage; Measures; Methodology; Molecular; Moods; Morbidity - disease rate; Outcome; Pathway interactions; Persons; Process; Production; Risk; Sampling Studies; Social support; Source; Spouses; Standardization; Stress; Testing; Time; Unmarried; Visit; Withdrawal; base; biobehavior; cost; cytokine; frontier; healthspan; innovation; insight; mortality; novel; parent grant; prospective; public health relevance; research study; response; telomere

Abstract Marriage is the central relationship for the majority of adults, and morbidity and mortality are reliably lower for the married than the unmarried. However, the simple presence of a spouse is not necessarily protective: a troubled marriage simultaneously provides a prime source of stress while limiting a partner's ability to seek support in other relationships. Marital disagreements that are marked by high rates of negative or punishing behaviors (e.g., hostility, sarcasm, withdrawal), hallmarks of marital distress, increase proinflammatory cytokine production; marital discord's notable consequences include amplified risk and poorer outcomes for inflammation-related disorders. In contrast to the negative or punishing behaviors that clearly promote marital distress, a growing literature suggests that positive marital interactions are central to satisfying relationships, and may benefit health. Capitalization behaviors (encouraging, supportive responses that follow disclosure of positive events) are among the most influential positive marital behaviors. Using three state-of-the-art molecular aging biomarkers associated with inflammation (telomere length, p16INK4a expression, and epigenetic age, the status of an individual's epigenetic clock), we address novel questions: Do unhappy marriages accelerate molecular aging? Can happy marriages slow molecular aging and extend both lifespan and health span (the length of time that a person is healthy—not just alive)? Drawing on behavioral, immunological, and molecular aging research, this study will assess concurrent and prospective relationships between key marital behaviors and molecular aging biomarkers. Accordingly, at the baseline visit, couples will be asked to resolve a disagreement, and they will also discuss positive personal events; these discussions will be behaviorally coded. Blood samples will provide data on molecular aging biomarkers in addition to couples' inflammatory responsiveness to the interactions. The couples' second visit, two years after the first, will assess changes in marital quality, inflammation, and the three molecular aging biomarkers. We have three specific aims: Aim 1: To characterize the concurrent and prospective relationships between couples' interactive behaviors and mood, inflammation, and aging biomarkers. Aim 2: To assess the relationships among inflammation and the molecular aging biomarkers. Aim 3: This exploratory aim addresses the relative contributions of gender to mood, inflammation, inflammatory responsiveness, and the aging biomarkers, as well as actor-partner effects on these outcomes. This proposal's novel methodology provides a way to test innovative and original hypotheses about the ways that marital behavior impacts lifespan and health span. The interactions among behavior, inflammation, and molecular aging represent an important new frontier for understanding how one's closest personal relationship can accelerate or slow aging. This project will help illuminate the mechanisms through which marriage influences our health and longevity -- for good or ill.

抽象的 婚姻是大多数成年人的核心关系，发病率和死亡率确实较低 已婚人士比未婚人士。然而，配偶的简单存在并不一定具有保护作用： 陷入困境的婚姻同时成为压力的主要来源，同时限制了伴侣寻求帮助的能力 其他关系中的支持。婚姻分歧的特点是负面或惩罚性的比率很高 行为（例如，敌意、讽刺、退缩）、婚姻困扰的标志、促炎症增加 细胞因子的产生；婚姻不和的显着后果包括风险放大和结果较差 炎症相关疾病。与明显促进婚姻的消极或惩罚性行为相反 越来越多的文献表明，积极的婚姻互动是令人满意的关系的核心， 并可能有益于健康。大写行为（披露信息后的鼓励性、支持性反应） 积极事件）是最有影响力的积极婚姻行为之一。采用三种最先进的 与炎症相关的分子衰老生物标志物（端粒长度、p16INK4a 表达和表观遗传 年龄，个人表观遗传时钟的状态），我们解决了新问题：婚姻不幸福吗？ 加速分子老化？幸福的婚姻可以减缓分子衰老并延长寿命和健康吗 跨度（一个人健康的时间长度——不仅仅是活着）？借鉴行为学、免疫学和 分子衰老研究，这项研究将评估关键婚姻之间的同时和前瞻性关系 行为和分子衰老生物标志物。因此，在基线访视时，夫妇将被要求解决一个问题 分歧，他们也会讨论积极的个人事件；这些讨论将在行为上 编码。除了夫妻炎症之外，血液样本还将提供分子衰老生物标志物的数据 对交互的反应。夫妇俩的第二次访问是在第一次访问两年后，将评估 婚姻质量、炎症和三个分子衰老生物标志物。 我们有三个具体目标： 目标 1：描述之间的并发关系和预期关系 夫妻的互动行为和情绪、炎症和衰老生物标志物。目标 2：评估 炎症与分子衰老生物标志物之间的关系。目标 3：探索性目标 探讨性别对情绪、炎症、炎症反应性和炎症反应的相对影响 衰老的生物标志物，以及演员-伴侣对这些结果的影响。 该提案的新颖方法提供了一种测试有关创新和原创假设的方法 婚姻行为影响寿命和健康的方式。行为、炎症、 和分子衰老代表了了解一个人最亲密的个人如何 关系可以加速或减缓衰老。该项目将有助于阐明其机制 婚姻影响我们的健康和寿命——无论好坏。

项目成果

Individual, relational, and developmental-contextual pathways linking marriage to health: Reply to Brazeau, Pfund, and Hill (2020).

将婚姻与健康联系起来的个人、关系和发展背景路径：回复 Brazeau、Pfund 和 Hill (2020)。

• DOI: 10.1037/amp0000578
• 发表时间: 2020
• 期刊: The American psychologist
• 作者: Shrout,MRosie;Kiecolt-Glaser,JaniceK
• 通讯作者: Kiecolt-Glaser,JaniceK

Gut Microbiota Richness and Diversity Track With T Cell Aging in Healthy Adults.

健康成人肠道微生物群丰富度和多样性与 T 细胞衰老的关系。

• DOI: 10.1093/gerona/glad276
• 发表时间: 2024
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: Madison,AnneliseA;Burd,ChristinE;Andridge,Rebecca;Wilson,StephanieJ;Bailey,MichaelT;Belury,MarthaA;Spakowicz,DanielJ;Malarkey,WilliamB;Kiecolt-Glaser,JaniceK
• 通讯作者: Kiecolt-Glaser,JaniceK