Senior Research Career Scientist

摘要： 退伍军人人口在年龄上是倾斜的，超过55%的退伍军人已经超过65岁 年龄。肌肉大小、力量和力量不足的老年人可能会在一定程度上变得行动不便 简单地走到邮箱就是他们身体容量的上限。与年龄相关的血管 功能障碍导致肌肉退化，特别是在下肢，被描述为一种 由于缺乏运动和肌肉萎缩导致虚弱和低功率产生，从而导致 活动减少和更大的活动限制导致更明显的血管和肌肉 恶化。理查森博士研究的中心目标是减缓这种血管老化的过程 达到了抗疲劳性和灵活性受损的目的，血管老化继续得到缓解。因此， 理查森博士的工作对退伍军人管理局和康复医学具有重要意义。由于理查森医生的 研究兴趣，与与衰老过程相关的血管和代谢变化有关，他是 2007年从加州大学圣地亚哥分校生理学系招聘到加州大学 犹他州老年医学分部和盐湖城老年医学、研究、教育和临床中心 (GRECC)，分别担任教授和研究副主任。2015年，理查森博士收到了一份 退伍军人康复研究服务、高级研究职业科学家(SRCS)奖和 申请书代表他要求续签这项裁决。自2015年获得SRCS奖以来，Dr。 理查森已经发表了110多篇论文，在同行评议的优秀期刊上传播他的研究成果。Dr。 理查森从事各种综合生理学研究已近30年，到目前为止， 他发表了近300篇论文，h指数为69，他的作品被引用了16000多次。 为表彰理查森博士对该领域的贡献，2018年，他被授予荣誉博士学位， 毕业于他的母校，英国伦敦的布鲁内尔大学。目前，他是两个人中的PI VA RR&D成就奖，一个专注于血管系统在阿尔茨海默病中的作用，另一个 开发一种有前景的、具有临床相关性的血管健康评估。他是另一个RR&D的副主管 资助的MERIT和CSR&D资助的MERIT以及两个NIH资助的R01。此外，理查森博士还 成功指导了40多名研究生、博士后和教职员工，证明了这一点 事实上，他目前是NIH T32机构培训补助金的PI，名为心血管疾病(和 另外两个T32的导师，心脏病学和肺科)，美国心脏协会机构的合作伙伴 培训补助金，并刚刚开始指导他的第三个VA CDA2获得者。理查森医生现在 在他作为全职退伍军人管理局科学家的第14年，他热衷于继续他为退伍军人管理局和RR&D服务的工作 通过SRCS奖励机制继续提供支持。

Abstract: The Veteran population is skewed in terms of age, with more than 55% of Veterans already over 65 years of age. Older individuals with deficits in muscle size, strength and power can become mobility-limited to a degree that simply walking to the mailbox is at the upper limit of their physical capacity. An age-associated vascular dysfunction leading to muscle de-conditioning, particularly in the lower extremities, has been described as a “vicious loop” as inactivity and muscle atrophy result in weakness and low power production which leads to reduced mobility and an even greater restriction of activity leading to even more pronounced vascular and muscle deterioration. The central goal of Dr. Richardson’s research is to attenuate the process of vascular aging such that fatigue resistance and impaired mobility are achieved and vascular aging continues to be attenuated. Thus, Dr. Richardson’s work has significant implications for the VA and rehabilitative medicine. Due to Dr. Richardson’s research interests, related to the vascular and metabolic changes associated with the aging process, he was recruited from the Division of Physiology, at the University of California, San Diego, in 2007 to the University of Utah, Division of Geriatrics, and the Salt Lake City Geriatrics, Research, Education, and Clinical Center (GRECC), as a Professor and Associate Director for Research, respectively. In 2015 Dr. Richardson received a VA Rehabilitation Research Service, Senior Research Career Scientist (SRCS) Award and the current application represents his request to renew this award. Since, receiving the SRCS Award, in 2015, Dr. Richardson has published over 110 papers disseminating his research in good peer reviewed journals. Dr. Richardson has worked on a wide variety of integrative physiologic studies for almost 30 years, and, as of now, he has published almost 300 papers, has an h-index of 69, and his work has been cited well over 16,000 times. In recognition of Dr. Richardson’s contributions to the field, in 2018, he was Awarded an Honorary Doctorate, in Biological Sciences, from his alma mater, Brunel University in London England. Currently, he is the PI of two VA RR&D Merit Awards, one focusing on the role of the vasculature in Alzheimer’s Disease and the other developing a promising, clinically relevant, assessment of vascular health. He is the Co-I on another RR&D funded Merit and a CSR&D funded Merit as well as two NIH funded R01s. Additionally, Dr. Richardson has successfully mentored well over 40 people at the Graduate, Post-Doctoral, and Faculty levels, as evidenced by the fact that he is currently the PI of NIH T32 Institutional Training Grant entitled Cardiovasomobility (and a mentor on two other T32s, Cardiology and Pulmonary), a Co-I of an American Heart Association Institutional Training Grant, and is just embarking on the mentorship of his third VA CDA2 recipient. Dr. Richardson is now in his 14th year as full time VA scientist and is keen to carry on his work for the VA and the RR&D Service with continued support through the SRCS Award mechanism.