Senior Research Career Scientist

高级研究职业科学家

• 批准号: 10640861
• 负责人: Russell S. Richardson
• 金额: --
• 依托单位: VA SALT LAKE CITY HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10640861
• 关键词: Acceleration; Age; Age Years; Aging; Alzheimer' s Disease; American; American Heart Association; Area; Attenuated; Award; Biological Sciences; Blood Vessels; Businesses; California; Cardiology; Cities; Clinical Research; Cognition; Coupled; Critical Care; Data; Development; Disease; Doctor of Philosophy; Education; Elderly; England; Extensor; Faculty; Fatigue; Functional disorder; Funding; Geriatrics; Goals; Grant; Health; Healthcare; Healthcare Systems; Immobilization; Impairment; Individual; Institution; Journals; Laboratory Research; Leg; Link; London; Long-Term Care; Lower Extremity; Lung; Mediating; Mediation; Medical Research; Medicine; Mentors; Mentorship; Metabolic; Metabolic Control; Mission; Muscle; Muscular Atrophy; Paper; Peer Review; Persons; Physical Capacity; Physical Function; Physiological; Physiology; Play; Population; Postdoctoral Fellow; Process; Production; Productivity; Publishing; Rehabilitation therapy; Research; Research Priority; Resistance; Role; Scientist; Services; Skeletal Muscle; Societies; Sodium Chloride; Students; Training; United States National Institutes of Health; Universities; Utah; Vascular Diseases; Veterans; Viscosity; Walking; Work; age related; aged; care costs; career; clinical center; clinically relevant; college; deconditioning; demographics; fall risk; frailty; indexing; interest; military veteran; professor; programs; recruit; rehabilitation research; research and development; respiratory; walking speed

Abstract: The Veteran population is skewed in terms of age, with more than 55% of Veterans already over 65 years of age. Older individuals with deficits in muscle size, strength and power can become mobility-limited to a degree that simply walking to the mailbox is at the upper limit of their physical capacity. An age-associated vascular dysfunction leading to muscle de-conditioning, particularly in the lower extremities, has been described as a “vicious loop” as inactivity and muscle atrophy result in weakness and low power production which leads to reduced mobility and an even greater restriction of activity leading to even more pronounced vascular and muscle deterioration. The central goal of Dr. Richardson’s research is to attenuate the process of vascular aging such that fatigue resistance and impaired mobility are achieved and vascular aging continues to be attenuated. Thus, Dr. Richardson’s work has significant implications for the VA and rehabilitative medicine. Due to Dr. Richardson’s research interests, related to the vascular and metabolic changes associated with the aging process, he was recruited from the Division of Physiology, at the University of California, San Diego, in 2007 to the University of Utah, Division of Geriatrics, and the Salt Lake City Geriatrics, Research, Education, and Clinical Center (GRECC), as a Professor and Associate Director for Research, respectively. In 2015 Dr. Richardson received a VA Rehabilitation Research Service, Senior Research Career Scientist (SRCS) Award and the current application represents his request to renew this award. Since, receiving the SRCS Award, in 2015, Dr. Richardson has published over 110 papers disseminating his research in good peer reviewed journals. Dr. Richardson has worked on a wide variety of integrative physiologic studies for almost 30 years, and, as of now, he has published almost 300 papers, has an h-index of 69, and his work has been cited well over 16,000 times. In recognition of Dr. Richardson’s contributions to the field, in 2018, he was Awarded an Honorary Doctorate, in Biological Sciences, from his alma mater, Brunel University in London England. Currently, he is the PI of two VA RR&D Merit Awards, one focusing on the role of the vasculature in Alzheimer’s Disease and the other developing a promising, clinically relevant, assessment of vascular health. He is the Co-I on another RR&D funded Merit and a CSR&D funded Merit as well as two NIH funded R01s. Additionally, Dr. Richardson has successfully mentored well over 40 people at the Graduate, Post-Doctoral, and Faculty levels, as evidenced by the fact that he is currently the PI of NIH T32 Institutional Training Grant entitled Cardiovasomobility (and a mentor on two other T32s, Cardiology and Pulmonary), a Co-I of an American Heart Association Institutional Training Grant, and is just embarking on the mentorship of his third VA CDA2 recipient. Dr. Richardson is now in his 14th year as full time VA scientist and is keen to carry on his work for the VA and the RR&D Service with continued support through the SRCS Award mechanism.

摘要： 退伍军人人口在年龄方面是倾斜的，超过55%的退伍军人已经超过65岁。 年龄肌肉大小、力量和力量不足的老年人可能会在一定程度上受到行动能力的限制 仅仅是走到邮箱已经是他们身体能力的上限了。与年龄相关的血管 导致肌肉去调节的功能障碍，特别是在下肢，已经被描述为一种 “恶性循环”，因为不活动和肌肉萎缩导致虚弱和低功率生产， 活动性降低，活动受到更大限制，导致血管和肌肉 恶化理查森博士研究的中心目标是减缓血管老化的过程， 从而获得抗疲劳性和受损的活动性，并且血管老化继续减弱。因此，在本发明中， 博士理查森的工作对退伍军人事务部和康复医学有重要意义。由于理查德森博士的 他的研究兴趣是与衰老过程相关的血管和代谢变化， 2007年，他从加州大学圣地亚哥分校生理学系被招募到加州大学圣地亚哥分校。 犹他州老年医学部和湖城老年医学研究、教育和临床中心 （GRECC），分别担任教授和研究副主任。2015年，理查德森博士获得了 VA康复研究服务，高级研究职业科学家（SRCS）奖和目前的 他的申请代表他要求延长这一奖项。自2015年获得SRCS奖以来，Dr. 理查森发表了110多篇论文，在优秀的同行评审期刊上传播他的研究。博士 理查森从事各种综合生理研究近30年，截至目前， 他发表了近300篇论文，h指数为69，他的工作被引用超过16，000次。 为了表彰Richardson博士对该领域的贡献，2018年，他被授予荣誉博士学位， 生物科学，来自他的阿尔马母校，英国伦敦布鲁内尔大学。目前，他是两个PI VA RR&D优异奖，一个侧重于血管系统在阿尔茨海默病中的作用，另一个 开发一种有前景的、临床相关的血管健康评估。他是另一个RR&D的Co-I 一个由CSR&D资助的Merit和两个由NIH资助的R 01。此外，Richardson博士 成功地指导了40多人在研究生，博士后，和教师的水平，证明了 事实上，他目前是美国国立卫生研究院T32机构培训补助金的PI，名为“适应性”（以及 其他两个T32的导师，心脏病学和肺），美国心脏协会机构的Co-I 培训补助金，并刚刚开始对他的第三个VA CDA 2收件人导师。理查德森博士现在 在他的第14年作为全职退伍军人事务部科学家，并热衷于继续他的工作，为退伍军人事务部和RR&D服务， 通过SRCS奖励机制继续提供支持。