In vivo MRI Measures of Brain Metabolism in Traumatic Brain Injury
创伤性脑损伤中脑代谢的体内 MRI 测量
基本信息
- 批准号:10444479
- 负责人:
- 金额:$ 39.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-01 至 2027-04-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAffectAlzheimer&aposs DiseaseAnimalsAreaAutoradiographyBehavioralBioenergeticsBiological AssayBlood - brain barrier anatomyBlood GlucoseBrainBrain InjuriesBrain regionCause of DeathCerebrovascular CirculationCerebrumChemicalsChronicClinicalClinical TrialsDataDevelopmentDiagnosisDiffuseDiffusion Magnetic Resonance ImagingDiseaseEnergy MetabolismEpilepsyEventFoundationsFunctional disorderGlucoseGoalsHeadHumanHypoxiaImageImage EnhancementImaging DeviceImmunohistochemistryImpairmentInjuryInterventionLithiumMagnetic Resonance ImagingMeasuresMechanicsMental DepressionMetabolicMetabolic DiseasesMetabolismMethodologyMicrodialysisModalityModelingMolecularMood stabilizersNerve DegenerationNeurodegenerative DisordersNeurologicNeurological outcomeOutcomePathologyPatientsPerfusionPharmacotherapyPhasePositron-Emission TomographyProcessPrognosisProtonsPublic HealthPublishingQuality of lifeRadioisotopesRattusResolutionRiskSchemeSensitivity and SpecificitySeveritiesSignal TransductionSourceSpectrum AnalysisTBI treatmentTechniquesTimeTimeLineTissuesTracerTranslatingTraumatic Brain InjuryTreatment EfficacyUnited StatesUnited States Food and Drug AdministrationValproic Acidanalytical methodaxon injurybaseblood flow measurementbrain metabolismbrain tissueclinically relevantcontrast enhanceddesigndisabilityefficacy evaluationglucose metabolismglucose monitorimprovedin vivoneurotransmissionneurotransmitter releaseneurovascularneurovascular couplingnon-invasive imagingnon-invasive monitornovelpersonalized careprognostic indicatorpublic health relevancerepairedtherapy developmenttissue injurytooltreatment effecttreatment strategy
项目摘要
PROJECT SUMMARY
Traumatic brain injury (TBI) represents a major public health concern in the United States. TBI can result in
long-term neurological complications, including neurodegeneration, behavioral dysfunction, depression and
epilepsy that seriously affect patient quality-of-life. Brain glucose utilization has been found decreased in 60%
of patients with chronic TBI and is one of the prognostic indicators for the long-term outcome of TBI. Both
animal and human studies have identified that the neurovascular uncoupling between cerebral blood flow
(CBF) and brain tissue energy demands is a key factor for cerebral metabolic crisis in the TBI brain. The
neurovascular uncoupling results in energy mismatch that disrupts normal neuroglial function and arrests
repairing process. Despite numerous clinical trials on potential therapies, there is no U.S. Food and Drug
Administration approved drug therapy for the treatment of TBI. One of the reason clinical trials failed is due to
the inability that can accurately evaluate the region-specific perturbations of brain glucose metabolism and
determine if a treatment can restore neurovascular coupling in the TBI brain. Existent glucose measuring
techniques, including microdialysis, continuing blood glucose monitoring, spectroscopy, or positron emission
tomography (PET) which uses tracer radioisotopes, provide insufficient resolution to determine region-specific
glucose utilization in the brain. In this proposal, we determine to assess the utility of a novel MRI-based
Chemical Exchange Saturation Transfer (CEST) imaging, to provide the needed high-resolution for measuring
region-specific metabolism for TBI. The glucose detecting CEST MRI (glucoCEST) measures brain glucose by
detecting the exchangeable proton signals of glucose without using radioisotopes and generates glucose
mapping in a resolution >100 times higher than PET scans. Our preliminary and published data have
demonstrated that glucoCEST may be feasible to detect the delayed hypometabolism of diffuse TBI in rats. We
propose to combine high-resolution glucoCEST and the Dynamic Contrast Enhanced (DCE) perfusion MRI for
concomitant CBF measurements to identify the neurovascular coupling state following TBI over time. Our aims
are designed to (1) Identify the contrast mechanism of in vivo glucoCEST in the TBI brain to enhance the
sensitivity and specificity of glucoCEST with advanced acquisition scheme and analytical models, (2)
Characterize perturbations in brain glucose metabolism and perfusion deficits in the TBI brain, and (3)
Demonstrate the potential application of the dual-modality CEST-DCE MRI to noninvasively monitor the
treatment effects of a clinically-recommended intervention for TBI. Overall, these studies will provide a strong
technical and scientific foundation to move the field forward in utilization of advanced MRI for personalized
care in the clinical arena and determine the best treatment strategy for the brain injured patients.
项目总结
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Tsang-Wei Tu其他文献
Tsang-Wei Tu的其他文献
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{{ truncateString('Tsang-Wei Tu', 18)}}的其他基金
In vivo MRI Measures of Brain Metabolism in Traumatic Brain Injury
创伤性脑损伤中脑代谢的体内 MRI 测量
- 批准号:
10614054 - 财政年份:2022
- 资助金额:
$ 39.39万 - 项目类别:
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