Developmental Funds

发展基金

• 批准号: 10443644
• 负责人: Stephen D. Nimer
• 金额: $ 46.55万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-10 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10443644
• 关键词: Address; Area; Award; Behavioral Research; Bioinformatics; Biometry; Cancer Center Support Grant; Cancer Control Research Program; Cancer Model; Catchment Area; Clinical Trials; Collaborations; Community Outreach; Comprehensive Cancer Center; Conduct Clinical Trials; Development; Ensure; Epigenetic Process; Evaluation; Faculty; Financial Support; Flow Cytometry; Funding; Goals; Grant; Individual; Investigational Therapies; Investments; Leadership; Legal patent; Malignant Neoplasms; Molecular; Peer Review; Pilot Projects; Process; Publications; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Science; Scientist; Series; Strategic Planning; Therapeutic; Translational Research; Tumor Biology; anticancer research; base; cancer genomics; community based research; community engagement; faculty support; innovation; member; programs; recruit; service utilization; stem; tool

PROJECT SUMMARY: DEVELOPMENTAL FUNDS Shortly after assuming the Directorship of Sylvester Comprehensive Cancer Center (Sylvester) in 2012, Stephen D. Nimer, MD, initiated a center-wide effort to ensure that all cancer-relevant investments are strategically made. Nimer’s first goals were to systematically build needed research infrastructure, connect individuals and groups of investigators, build teams of scientists to create research programs for the center, and increase community engagement and outreach activities to gain a greater understanding of the diverse needs in Sylvester’s catchment area. In 2013, Sylvester leadership initiated a formal strategic planning process, resulting in the 2014-2018 Strategic Plan. This plan prioritized addressing the needs of Sylvester members, including the need for better shared resources (SRs), more reliable support for conducting clinical trials and translational science, and more financial support of outstanding cancer research. Since 2014, a total of $5.7M has been awarded via the peer-reviewed Intramural Funding Program, which includes nine award mechanisms to encourage new areas of cancer research, bridge investigator’s grant funding, support junior faculty, and promote innovative clinical trials that match Sylvester’s strategic goals and promote collaborative team science. The return on investment, calculated based on results stemming from the direct support of research projects, has been $25.2M in new grant funding, 22 publications (of which 64% are collaborative), new research tools, and three applications with one patent approved. To fulfill the needs of the three research programs, Sylvester has also invested $14M in the development of the Flow Cytometry, Onco-Genomics, Biostatistics and Bioinformatics, and Behavioral and Community-Based Research Shared Resources. Seventy percent of Sylvester members utilize services these shared resources provide. Additionally, Sylvester has invested $2.9M since 2016 in three highly translational developing shared resources: the Biospecimen, Cancer Modeling, and Molecular Therapeutics Shared Resources, for which CCSG Developmental Funds support is requested.

项目摘要：发展基金 2012 年担任西尔维斯特综合癌症中心 (Sylvester) 主任后不久， Stephen D. Nimer 医学博士发起了一项全中心范围的努力，以确保所有与癌症相关的投资都得到落实 战略性地制定的。尼默的首要目标是系统地建立所需的研究基础设施、连接 个人和研究小组建立科学家团队为中心制定研究计划， 并增加社区参与和外展活动，以更好地了解多元化 西尔维斯特集水区的需求。 2013年，西尔维斯特领导层启动了正式的战略规划 过程，最终形成 2014-2018 年战略计划。该计划优先满足西尔维斯特的需求 成员，包括需要更好的共享资源（SR），为进行临床提供更可靠的支持 试验和转化科学，以及对杰出癌症研究的更多财政支持。自2014年以来，共 通过同行评审的校内资助计划授予了 570 万美元，其中包括九个奖项 鼓励癌症研究新领域、为研究者提供资助、支持青年人的机制 教师，并促进符合西尔维斯特战略目标并促进协作的创新临床试验 团队科学。投资回报率，根据直接支持的结果计算 研究项目，新拨款金额达 2520 万美元，22 篇出版物（其中 64% 为合作出版物）， 新的研究工具，以及三项申请，其中一项专利获得批准。满足三项研究的需要 Sylvester 还投资了 1400 万美元用于流式细胞术、肿瘤基因组学、 生物统计学和生物信息学，以及行为和社区研究共享资源。七十 % 的西尔维斯特成员使用这些共享资源提供的服务。此外，西尔维斯特还 自 2016 年以来投资 290 万美元用于三个高度转化的开发共享资源：生物样本、癌症 建模和分子治疗共享资源，CCSG 发展基金对此提供支持 要求。