Mouse Models of Human Cancer Database

人类癌症数据库的小鼠模型

基本信息

批准号：
10443699
负责人：
CAROL J BULT
金额：
$ 72.03万
依托单位：
JACKSON LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-12-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10443699
关键词：
Adopted Affect Alleles Animal Model Bioinformatics Biological Biological Models Biology Cancer Model Catalogs Clinical Research Collaborations Collection Communities Community Outreach Complex Computer software Data Data Aggregation Data Analyses Data Commons Data Discovery Databases Development Educational workshop Ensure European Evolution Feedback Frequencies Funding Gene Expression Genes Genetic Genetic Research Genetically Engineered Mouse Genomics Goals Growth Histopathology Human Human Genetics Image Immune Inbreeding Informatics Infrastructure Institutes International Investigation Knowledge Laboratory mice Literature Machine Learning Maintenance Malignant Neoplasms Mission Modeling Modernization Molecular Genetics Molecular Profiling Mouse Strains Mus Nomenclature Oncogenes Pattern Peer Review Pharmaceutical Preparations Phenotype Play Predisposition Process Reaction Time Research Personnel Resources Review Literature Role Security Semantics Services Standardization Strategic Planning Testing Tumor Biology Tumor Suppressor Proteins Variant Visualization Work analysis pipeline base bioinformatics resource cBioPortal cancer genetics cancer therapy clinically relevant data ecosystem data standards database design design genomic data genomic platform human cancer mouse model human model humanized mouse improved in vivo in vivo Model insight knowledgebase metadata standards mouse development mouse model mutant novel therapeutic intervention online resource outreach patient derived xenograft model pre-clinical public health relevance response social media software development symposium tool translational cancer research translational potential treatment response tumor tumorigenesis usability web app web site

项目摘要

PROJECT SUMMARY/ABSTRACT The laboratory mouse is the preeminent animal model system for investigation into the biology and genetics of human cancer. Mouse models have provided key insights into cancer susceptibility, the molecular genetics of tumor suppressor and oncogenes, and therapy response in pre-clinical and co-clinical studies. Human tumors engrafted into immune compromised and humanized mice (aka, Patient Derived Xenografts) are playing an increasingly important role as a powerful preclinical platform for testing new cancer treatments. The Mouse Models of Human Cancer (MMHC) database is a unique on-line compendium of mouse models for human cancer. MMHCdb provides electronic access to expertly curated and harmonized information on diverse mouse models for human cancer along with tools for accessing and visualizing associated data from these models. This in turn, facilitates the selection of appropriate strains of mice for cancer genetics research. MMHCdb integrates data derived from peer-reviewed literature and from direct submissions from researchers. Data in MMHCdb are also obtained from other bioinformatics resources including PathBase, HUGO Human Gene Nomenclature database, the Gene Expression Omnibus (GEO), and ArrayExpress. In this proposal we describe our plans for the continued development of MMHCdb with an emphasis on expanded support for analysis of tumor genomic data and drug response data from Patient Derived Xenograft models. To accomplish these goals we will build on successful collaborations to develop data standards for PDX models that are now widely adopted. The major goals for the project renewal include the following: · continue to populate MMHCdb with data on strain-specific patterns of tumorigenesis in inbred, mutant, and genetically engineered mice, · leverage collaborations with Seven Bridges and PDXNet to analyze genomic data for PDX models using a common analysis pipeline, · develop a platform for the analysis of PDX genomic and drug response data, and · support the infrastructure of MMHCdb and our user community through ongoing database maintenance, development of new software components, user support services, and community outreach activities.

项目摘要/摘要实验室小鼠是对生物学和遗传学投资的杰出动物模型系统人类癌。小鼠模型为癌症易感性提供了关键的见解，即分子遗传学肿瘤抑制剂和癌基因，以及临床前和共同临床研究中的治疗反应。人类肿瘤植入免疫折衷和人源性小鼠（又称患者衍生的异种移植物）正在玩作为测试新癌症治疗的强大临床前平台，日益重要的作用。人类癌症的小鼠模型（MMHC）数据库是小鼠模型的独特在线纲要人类癌。 MMHCDB提供了对专业策划和协调信息的电子访问潜水小鼠的人类癌症模型以及用于访问和可视化相关数据的工具这些模型。反过来，这促进了用于癌症遗传学研究的适当小鼠菌株的选择。 MMHCDB的集成数据来自同行评审的文献以及研究人员的直接提交。 MMHCDB中的数据也来自其他生物信息学资源，包括Pathbase，Hugo Human 基因命名法数据库，基因表达综合（GEO）和ArrayExpress。在此提案中，我们描述了MMHCDB持续发展的计划，重点是扩大了对来自患者衍生异种移植的肿瘤基因组数据和药物反应数据的分析的支持型号。为了实现这些目标，我们将基于成功的合作，以制定数据标准现在广泛采用的PDX模型。该项目更新的主要目标包括以下内容：继续使用MMHCDB填充有关菌株特异性肿瘤发生模式的数据基因工程的小鼠，利用与七个桥和PDXNET合作，使用A分析PDX模型的基因组数据通用分析管道， ·开发一个平台，用于分析PDX基因组和药物反应数据，以及 ·通过正在进行的数据库维护，支持MMHCDB和我们的用户社区的基础架构，开发新的软件组件，用户支持服务和社区外展活动。