Prenatal environmental determinants of health in young adulthood: a lifecourse approach

成年早期健康的产前环境决定因素：生命全程方法

• 批准号: 10444078
• 负责人: Marie-France Hivert
• 金额: $ 137.15万
• 依托单位: HARVARD PILGRIM HEALTH CARE, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10444078
• 关键词: Address; Adolescence; Adult; Adverse effects; Air Pollution; Animal Experiments; Anxiety; Behavior; Behavior Disorders; Behavioral; Biological; Biological Markers; Biology; Birth; Blood Pressure; Bone Density; Characteristics; Chemical Exposure; Chemicals; Child; Child Behavior; Childhood; Chronic Disease; Data; Data Collection; Development; Diet; Disease; Eating Behavior; Elderly; Elements; Environment; Ethnic Origin; Exposure to; Fertility; Funding; Future; Growth; Health; Health Status; Health behavior; Hormones; Human; Hyperglycemia; Hypertension; Individual; Inflammation; Life; Life Style; Lipids; Long-Term Effects; Longevity; Longitudinal cohort; Maternal Behavior; Measurement; Measures; Mediator of activation protein; Menstrual cycle; Metal exposure; Metals; Methods; National Institute of Child Health and Human Development; Neighborhoods; Obesity; Outcome; Participant; Personal Satisfaction; Physical activity; Policies; Population; Positioning Attribute; Pregnancy; Protocols documentation; Psychology; Public Health; Quality of life; Race; Reproductive Health; Research; Research Personnel; Resources; Risk Factors; Schools; Selection Bias; Seminal fluid; Sleep; Sleep Deprivation; Smoking; Social Environment; Teenagers; Thinness; Time; Tobacco; Translating; Unhealthy Diet; Weight; Weight Gain; Woman; analytical method; anxiety symptoms; base; blood pressure elevation; cardiometabolism; cohort; depressive symptoms; deprivation; disorder risk; experience; follow-up; improved; innovation; interest; lean body mass; lung health; maternal cigarette smoking; men; offspring; optimism; prenatal; prenatal experience; prenatal exposure; prevent; prospective; reproductive; sample collection; sedentary activity; sex; social; social factors; sperm quality; substance use; theories; tv watching; waist circumference; young adult

Summary/Abstract Young adulthood is the life stage when we should achieve peak health. Physically, young adults will have completed their growth, reached maximal lean body mass, and have optimal fertility. Many young adults will have completed school and live independently. While few young adults have overt chronic disease, many already have substantial risk factors such as hypertension, hyperglycemia, and obesity. Moreover, suboptimal lifestyle behaviors such as poor diet, insufficient sleep, and substance use, and symptoms of depression and anxiety prevent many young adults from reaching their full potential. Existing evidence suggests that the prenatal environment influences health and disease risks across the lifecourse. However, most human evidence is based on either short-term follow-up into childhood, when health is more plastic; or on retrospective data from adult cohorts in which exposures are limited or subject to substantial recall bias, and selection bias is likely considerable yet unquantifiable. The proposed project will address this topic leveraging the rich data already collected in the Project Viva pre- birth cohort. The project will include already-collected measures of prenatal maternal behaviors (diet, smoking, physical activity) and biology (inflammation, blood pressure, glycemia, weight gain, depressive/anxiety symptoms), as well as elements of the chemical (exposures to metals, PFAS, air pollution) and social environments (material hardship, neighborhood deprivation). Specific Aims will focus on following key domains of health to be assessed in 1000 young adults followed since prenatal life: Aim 1: Cardiometabolic Health, based on weight, waist circumference, blood pressure, and biomarkers (lipids, glycemia, inflammation). Aim 2: Reproductive Health, based on fertility markers including hormone levels, menstrual cycle characteristics (for women), and sperm quality/quantity (for men). Aim 3: Experiential Health and Wellbeing, based on perceived overall health and quality of life, measures of positive psychology (e.g. optimism), and low levels of depressive/anxiety symptoms Secondary Aim 4: Health behaviors, including diet and eating behaviors, physical and sedentary activities, tobacco and other substance use, and sleep. The primary hypothesis is that a more beneficial prenatal environment will be associated with better cardiometabolic, reproductive, and experiential health in young adulthood. Project Viva is uniquely positioned to address these important scientific questions. Ongoing support of this unique resource will provide an unparalleled opportunity to rigorously evaluate the extent to which developmental exposures influence health into adulthood.

总结/摘要 青年期是我们应该达到健康巅峰的生命阶段。从身体上讲，年轻人会有 完成生长，达到最大瘦体重，并具有最佳生育能力。许多年轻人将 完成学业并独立生活。虽然很少有年轻人患有明显的慢性病，但许多人 已经有大量的危险因素，如高血压，高血糖症和肥胖症。此外，次优 生活方式行为，如不良饮食，睡眠不足，物质使用，以及抑郁症的症状， 焦虑使许多年轻人无法充分发挥其潜力。 现有的证据表明，产前环境影响整个家庭的健康和疾病风险。 生命历程然而，大多数人类证据都是基于对儿童期的短期随访， 更可塑;或来自成人队列的回顾性数据，其中暴露有限或受 大量的回忆偏差和选择偏差可能是相当大的，但无法量化。 拟议的项目将利用Viva项目前期收集的丰富数据解决这一问题， 出生队列该项目将包括已经收集的产前母亲行为（饮食，吸烟， 身体活动）和生物学（炎症、血压、肥胖、体重增加、抑郁/焦虑 症状），以及化学品的元素（接触金属，PFAS，空气污染）和社会 环境（物质困难，邻里剥夺）。具体目标将侧重于以下关键领域 在1000名年轻成年人中评估产前生活后的健康状况： 目标1：心脏代谢健康，基于体重、腰围、血压和生物标志物（脂质， 炎症）。 目标2：生殖健康，基于生育指标，包括激素水平、月经周期 特征（女性）和精子质量/数量（男性）。 目标3：体验式健康和福祉，基于感知的整体健康和生活质量， 积极的心理学（例如乐观），以及低水平的抑郁/焦虑症状 次要目标4：健康行为，包括饮食和进食行为，身体和久坐活动， 烟草和其他物质的使用，以及睡眠。 主要的假设是，一个更有益的产前环境将与更好的 心脏代谢、生殖和经验健康。Project Viva的独特之处在于 来解决这些重要的科学问题。对这一独特资源的持续支持将提供 这是一个前所未有的机会，可以严格评估发育暴露对健康的影响程度 长大成人