Defining renal S1P/sPRR/AT1R pathway in salt-sensitive hypertension

盐敏感性高血压肾 S1P/sPRR/AT1R 通路的定义

• 批准号: 10293534
• 负责人: Tianxin Yang
• 金额: --
• 依托单位: VA SALT LAKE CITY HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10293534
• 关键词: Address; Antihypertensive Agents; Attenuated; Binding; Biological Markers; Biological Process; Blood Pressure; Cardiovascular Diseases; Chronic Kidney Failure; Data; Development; Enzymes; Equilibrium; Extracellular Domain; Fluid Balance; Generations; Goals; Hypertension; Inbred Dahl Rats; Injury to Kidney; Kidney; Mediating; Modeling; Pathogenesis; Pathway interactions; Peptide Hydrolases; Pharmacology; Production; Rattus; Receptor Inhibition; Receptor Signaling; Receptor, Angiotensin, Type 1; Regulation; Renal tubule structure; Renin; Renin-Angiotensin System; Renin-Angiotensin-Aldosterone System; Reporting; Role; Tertiary Protein Structure; Testing; Water; epithelial Na+ channel; human disease; hypertension treatment; hypertensive; inhibitor; insight; member; neutralizing antibody; novel; receptor; salt sensitive; salt sensitive hypertension; site-1 protease

The important role of renin-angiotensin-aldosterone system in the pathogenesis of hypertension is highlighted by the wide use of its inhibitors for treatment of hypertension. The current proposal will address the role of renal site-1 protease/soluble (pro)renin receptor in pathogenesis of salt-sensitive hypertension. The proposal has the potential to advance our understanding of the fundamental mechanism of hypertension and also to identify a novel target for antihypertensive therapies.

肾素-血管紧张素-醛固酮系统在原发性高血压发病中的作用 高血压由于其抑制剂在高血压治疗中的广泛应用而突出。 目前的建议将解决肾网站1蛋白酶/可溶性（原）肾素的作用， 受体在盐敏感性高血压发病机制中的作用。该提案有可能 提高我们对高血压基本机制的认识， 确定了抗高血压治疗的新靶点。