Basement Membrane Targeted Nanoparticles for Post-Surgical Adhesion Prevention

用于预防术后粘连的基底膜靶向纳米颗粒

• 批准号: 10297844
• 负责人: Andrew Zhuang Wang
• 金额: $ 39.36万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10297844
• 关键词: Abdomen; Adhesions; Affect; Affinity; Anti-Inflammatory Agents; Artificial nanoparticles; Basement membrane; Binding; Biomedical Engineering; Chemistry; Clinical Research; Collagen; Collagen Type IV; Complication; Coupled; Development; Dexamethasone; Disease; Encapsulated; Endothelium; Engineering; Formulation; Goals; Health Care Costs; In Vitro; Infertility; Inflammation; Injury; Injury to Peritoneum; Intestinal Obstruction; Liquid substance; Literature; Microscopic; Modeling; Morbidity - disease rate; Nanotechnology; Nitric Oxide; Operative Surgical Procedures; Pain; Patients; Pelvis; Peritoneal; Pharmaceutical Preparations; Prevention; Quality of life; Rattus; Reaction; Risk; Site; Specificity; Surface; Surgical Injuries; System; Therapeutic; Therapeutic Uses; Tissues; Transforming Growth Factor beta; Translating; Work; clinical translation; cost; crosslink; improved; in vivo; in vivo Model; inhibitor; innovation; interest; molecular targeted therapies; nanomedicine; nanoparticle; nanoparticle delivery; nanoparticle drug; novel; prevent; reaction rate; side effect; tissue injury

Abdominal surgery is an important treatment for many diseases. A frequent and serious side effect of abdominal surgery is the formation of post-surgical adhesions. Post-surgical adhesions can cause pain as well as other serious complications such as infertility and bowel obstruction. These complications affect many patients and the management of post-surgical adhesions can costs billions of dollars each year. Therefore, there has been strong interest in the development of strategies and agents that can prevent post-surgical adhesion formation. Current strategies to minimize adhesions generally involve the use of adhesion reducing liquids and large physical barriers. However, clinical studies have shown that the benefits of existing agents in reducing adhesions are quite limited. Thus, there is a strong need for the development of novel agents and strategies to reduce post- surgical adhesions. A key challenge in this effort is to provide barrier function and reduce inflammation at sites of tissue injury only while avoiding normal peritoneal surfaces. Recent advances in nanotechnology have enabled the development of nanoparticles (NPs) that can target specific molecules or tissue, such as collagen. We have shown that we can utilize these nanoparticles to form targeted microscopic barriers at sites of surgical injury. We hypothesize that we optimize our targeted NPs and the 2-NP system to enable a biologically targeted barrier for adhesion prevention. We further theorize that we can encapsulate and deliver anti-inflammatory therapeutics using these NPs and these drug containing NPs can further reduce risk of post-surgical adhesion formation. The central goal of this application is to engineer and optimize biologically targeted biodegradable NPs that can bind to sites of peritoneal injury, form a robust barrier and prevent surgical adhesion. To accomplish this goal, we plan to utilize our existing BM-targeted NP platform and formulate NPs with different sizes, compositions, binding chemistries, and encapsulate different anti-inflammatory therapeutics. These NPs will be evaluated for adhesion prevention using rat models of pelvic post-surgical adhesion. In summary, our application aims to apply advances in nanomedicine to develop novel agents for adhesion prevention. Our proposed work has potential to reduce the risk of post-surgical adhesion which will directly translate into improvement in patients’ quality of life.

腹部手术是许多疾病的重要治疗方法。的频繁和严重的副作用

项目成果

Biocompatible Nanocomposites for Postoperative Adhesion: A State-of-the-Art Review.

• DOI: 10.3390/nano14010004
• 发表时间: 2023-12-19
• 期刊: Nanomaterials (Basel, Switzerland)
• 作者: Kargozar S;Gorgani S;Nazarnezhad S;Wang AZ
• 通讯作者: Wang AZ

Tissue engineered cancer metastases as cancer vaccine to improve cancer immunotherapy.

组织工程癌症转移作为癌症疫苗来改善癌症免疫治疗。

• DOI: 10.1016/j.actbio.2022.09.059
• 发表时间: 2022
• 期刊: Acta biomaterialia
• 影响因子: 9.7
• 作者: Sultanpuram,NikhilaReddy;Ahmed,Umer;Peters,JonathanThomas;Zhang,Tian;Wang,AndrewZ
• 通讯作者: Wang,AndrewZ