Characterizing the oxysterol, 20-hydroxycholesterol, as a mediator of remyelination in multiple sclerosis

表征氧甾醇(20-羟基胆固醇)作为多发性硬化症髓鞘再生介质的作用

基本信息

  • 批准号:
    10311395
  • 负责人:
  • 金额:
    $ 44.28万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-01 至 2024-12-31
  • 项目状态:
    已结题

项目摘要

Multiple sclerosis (MS) is the most common neurological disease of young adulthood, affecting an estimated 1 million individuals in the U.S. and 2.5 million worldwide. MS is an autoimmune disease mediated by immune cells that trigger demyelination and neuronal damage of the central nervous system (CNS), resulting in debilitating neurological symptoms. While disease-modifying therapies have proven to be efficacious, they only prolong remission, they do not change disease course, and the majority of individuals with MS will likely experience worsening of clinical symptoms during the course of their disease. There is a significant gap in knowledge with respect to curative therapies for MS that prompt oligodendrocyte precursor cells to differentiate into mature oligodendrocytes (ODs), the main remyelinating cells within the adult CNS. Presented are exciting preliminary data in a white matter injury model of adult mice that establishes that 20-hydroxycholestrol (20HC) is capable of triggering remyelination in the CNS, and that it is capable of differentiating new ODs from the quiescent pool of OPCs in the CNS beyond the limited spontaneous regeneration that occurs during disease course. This resubmitted proposal builds upon this evocative preliminary data in an animal model of demyelination and proposes the application of leading edge molecular approaches to understanding the mechanisms of 20HC effect. The long-term goal of this proposal is to identify the efficacy of 20HC as a completely novel drug for reversing the progressive course of MS.
多发性硬化症(MS)是年轻人中最常见的神经系统疾病,据估计影响全球约1亿人

项目成果

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Eric J Benner其他文献

Eric J Benner的其他文献

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{{ truncateString('Eric J Benner', 18)}}的其他基金

Mechanisms of oxysterol-induced oligodendrogenesis
氧甾醇诱导少突胶质细胞发生的机制
  • 批准号:
    10295785
  • 财政年份:
    2019
  • 资助金额:
    $ 44.28万
  • 项目类别:
Mechanisms of oxysterol-induced oligodendrogenesis
氧甾醇诱导少突胶质细胞发生的机制
  • 批准号:
    10526396
  • 财政年份:
    2019
  • 资助金额:
    $ 44.28万
  • 项目类别:

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