Somatosensory stimulation therapies for movement disorders

体感刺激疗法治疗运动障碍

• 批准号: 10311109
• 负责人: Dawn Marie Taylor
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10311109
• 关键词: Area; Back; Brain; Chemical Exposure; Chronic; Clinical; Cutaneous; Deep Brain Stimulation; Disease; Dopamine; Effectiveness; Electrodes; Exhibits; Feedback; Frequencies; Future; General Population; Goals; Grant; Hindlimb; Human; Implant; Incidence; Limb structure; Modeling; Monitor; Motor; Motor Activity; Movement Disorders; Muscle; Neurodegenerative Disorders; Neurons; Neurotoxins; Operative Surgical Procedures; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; Pathologic; Pathology; Pathway interactions; Patients; Pattern; Performance; Peripheral; Pharmaceutical Preparations; Pharmacology; Pharmacotherapy; Phase; Physiologic pulse; Production; Randomized; Rattus; Records; Risk; Sensory; Signal Transduction; Skin; Somatosensory Receptor; Symptoms; Synapses; Technology; Testing; Therapeutic; Time; Tremor; Veterans; Work; brain surgery; combat; design; excitotoxicity; experience; improved; military veteran; minimally invasive; motor symptom; neural circuit; neural implant; novel; phase change; receptor; relating to nervous system; response; sensory input; side effect; somatosensory; subcutaneous; symptom management; symptomatic improvement

The goal of this project is to develop better ways to treat motor symptoms of Parkinson’s disease. People with Parkinson’s disease typically have higher amounts of synchronization across sensorimotor brain areas especially in the beta bands. This abnormal synchrony is thought to impede the production of normal motor patterns. Breaking up that excess synchrony can potentially improve motor symptoms and may help to renormalize brain network functioning. To that end, somatosensory stimulation will be used in a rat model of Parkinson’s disease to try to disrupt the excess brain network synchrony seen in Parkinson’s disease. Motor improvements and brain network changes will be directly compared when stimulation is used to activate two types of somatosensory receptors: 1) proprioceptive receptors (via electrically induced twitches in limb muscles), and 2) cutaneous receptors (via subcutaneous stimulation to activate the cutaneous receptors directly). Additionally, two types of stimulation patterns will also be compared: 1) a consistent desynchronizing pattern, and 2) a randomly varying pattern. Motor activity will be quantified before, during and after each combination of stimulation options. The stimulation option that improves motor performance the most will then be further assessed to determine whether it’s best to continuously apply that type of stimulation (open loop) or to only turn it on when the brain is exhibiting excess synchrony (closed loop). The results of this study will guide future human testing and could provide a less risky, non- or minimally invasive treatment option with fewer side effects than current stimulation options like deep brain stimulation.

该项目的目标是开发更好的方法来治疗帕金森氏症的运动症状 疾病帕金森病患者通常有更高的同步量， 尤其是在β带中。这种不正常的同步是 被认为阻碍了正常运动模式的产生。打破这种过度的同步 可以潜在地改善运动症状，并可能有助于重新正常化大脑网络功能。 为此，体感刺激将用于帕金森病大鼠模型， 来破坏帕金森氏症患者大脑网络的过度同步。电机 改善和大脑网络的变化将直接比较时，刺激是用来 激活两种类型的躯体感觉受体：1）本体感受受体（通过电 诱导肢体肌肉的抽搐），和2）皮肤受体（通过皮下刺激， 直接激活皮肤受体）。另外，两种类型的刺激模式也将 可以比较：1）一致的去干扰模式，和2）随机变化的模式。电机 将在刺激选项的每个组合之前、期间和之后量化活动。的 然后将进一步评估最能改善运动性能的刺激选项， 确定是否最好是连续应用该类型的刺激（开环）或仅 当大脑表现出过度同步（闭环）时打开它。本研究结果 将指导未来的人体试验，并可能提供一种风险较小、无创或微创的 比目前的刺激选择（如深部脑）副作用更少的治疗选择 刺激.