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Isotopic Labeling Rapid Antimicrobial Susceptibility Testing

Isotopic Labeling Rapid Antimicrobial Susceptibility Testing
同位素标记快速抗菌药物敏感性测试
批准号：
10325820
负责人：
ERIK J NILSSON
金额：
$25.65万
依托单位：
PATAIGIN, LLC
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
项目状态：
已结题
起止时间：
2021-07-01 至 2023-01-31
来源：
https://reporter.nih.gov/project-details/10325820
关键词：
AdoptedAgreementAntibiotic TherapyAntibioticsAntimicrobial ResistanceAntimicrobial susceptibilityBacteremiaBacteriaBaltimoreBiological AssayBiological MarkersBiotechnologyCell Culture TechniquesCessation of lifeCharacteristicsClinicalCollaborationsCommunicable DiseasesCompanionsCulture MediaDeath RateDeuteriumDeuterium OxideDevelopmentDiagnosisDiagnostic Reagent KitsEquipmentExperimental DesignsFDA approvedGoalsGoldGrowthHealthHospitalsHourIncidenceIncubatedInfectionInterventionIsotope LabelingLaboratoriesLifeLipidsMALDI-TOF Mass SpectrometryMarylandMedicalMedical DeviceMedical centerMicrobiologyMinimum Inhibitory Concentration measurementMorbidity - disease ratePatientsPerformancePhospholipidsPredispositionPreparationPrivatizationProcessPublic HealthReagentReportingReproducibilityResearchResearch PersonnelResearch ProposalsResistanceRunningSamplingSepsisSepticemiaSpecimenSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSpeedTechniquesTestingTimeUniversitiesWorkantimicrobialbasecostcost effectivedetection limitfightinginnovationinstrumentmass spectrometermedical schoolsmethod developmentmicrobialmortalitynovelpathogenresistance mechanismtool

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英文摘要
Abstract This proposal is for a rapid antimicrobial susceptibility test. Bacteremia and sepsis remain major health problems with high mortality. Progression is often rapid, so that a single hour saved in diagnosis time can significantly reduce septicemia death rates. Faster tests are needed to save lives. We propose Rigel, a rapid antimicrobial susceptibility test that makes use of a novel isotopic labelling mechanism.
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  • 批准号：
    10699890
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    $27.57万
  • 财政年份：
    2023
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    2018
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