A collaboration platform for proteomics biomarker analysis

描述(申请人提供)：提出了一种新的计算分析平台，使蛋白质组学生物标记物的发现和表征成为可能。提出的系统是一个广泛的学术和商业合作，集成了几个突出的蛋白质组学努力，并标志着虚拟集群技术在蛋白质组学中的首次重大应用。因此，拟议的平台为迄今阻碍蛋白质组学合作的安全性、可扩展性和易用性问题提供了新的解决方案。拟议的软件汇集了几个流行的开源蛋白质组学工具项目，以及开发科学计算解决方案的专家。通过将其应用于人类血浆蛋白质组的研究，结合国际合作的HuPo人类血浆蛋白质组项目，对所产生的系统进行了验证。这项研究建立在蛋白质组学和软件开发专家的成功合作基础上。令人印象深刻的研究团队包括蛋白质组学、公共卫生和生物信息学的先驱。该软件平台将广泛应用于生物机制的研究和复杂蛋白质体系的测量。对公众健康：这项研究的目的是实现一种新的蛋白质组学技术，既能降低蛋白质组学实验的成本，又能使所产生的数据在生物学上更具相关性。一个成功的结果将增加当前和未来一系列广泛研究的潜在健康益处。HUPO人类血浆蛋白质组计划是有史以来规模最大、范围最广的蛋白质组学合作。该项目的目标是对人的血浆和血清蛋白成分进行全面分析，并通过生物标记物的验证来识别个体内随时间变化的生物来源。通过与该项目密切合作，拟议的研究有可能对人类健康产生重大积极影响。

DESCRIPTION (provided by applicant): A novel computational analysis platform is proposed, which enables collaboration in the discovery and characterization of proteomics biomarkers. The proposed system is a broad academic-commercial collaboration, integrates several prominent proteomics efforts, and marks first major use in proteomics of virtual cluster technology. Consequently, the proposed platform offers new solutions to the security, scalability, and ease of use problems that have hampered proteomics collaborations to date. The proposed software brings together several popular open-source proteomics tools projects, together with experts in the development of scientific computing solutions. The resulting system is validated by applying it to the study the human plasma proteome, in conjunction with the international collaborative HUPO Human Plasma Proteome Project. This research builds on a successful collaboration of experts in proteomics and software development. The impressive research team includes pioneers in proteomics, public health, and bioinformatics. The proposed software platform will be widely applicable to the study of biological mechanisms and measurement of complex protein systems. to public health: The aim of this research is to enable a new proteomics technology that will both lower the cost of proteomics experiments and make the resulting data more biologically relevant. A successful outcome would increase the potential health benefit of a broad array of current and future research. The HUPO Human Plasma Proteome Project is the largest and broadest proteomics collaboration ever attempted. The goals of this project are comprehensive analysis of plasma and serum protein constituents in people, and identification of biological sources of variation within individuals over time, with validation of biomarkers. By working closely with this project, the proposed research has the potential for a substantial positive influence on human health.