Gradient-Echo Spectroscopic Imaging Study of Saturated Fat and Breast Cancer

饱和脂肪与乳腺癌的梯度回波光谱成像研究

• 批准号: 10322559
• 负责人: Sungheon Gene Kim
• 金额: $ 44.42万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-02 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10322559
• 关键词: Adipocytes; Adipose tissue; Affect; Androgens; Benign; Biopsy; Biopsy Specimen; Body fat; Body mass index; Breast; Breast Cancer Risk Factor; Breast Magnetic Resonance Imaging; Cancer Etiology; Cells; Cessation of life; Characteristics; Clinical; Clinical Management; Contralateral Breast; Core Biopsy; Data; Dental crowns; Development; Diagnostic; Dietary Fats; Disease; Estrogens; Fatty Acids; Fatty acid glycerol esters; Goals; Gold; Growth and Development function; Hormonal; Image; Individual; Inflammation; Intake; Intervention; Investigation; Lead; Lesion; Link; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Mammographic screening; Maps; Measurement; Measures; Menopause; Methods; Monounsaturated Fatty Acids; Pathology; Patients; Pilot Projects; Polyunsaturated Fatty Acids; Postmenopause; Prevention; Production; Prognosis; Reporting; Risk Factors; Role; Sample Size; Saturated Fatty Acids; Scanning; Serum; Source; Spatial Distribution; Stains; Structure; Testing; Time; Tissues; Unsaturated Fats; Woman; aggressive breast cancer; breast cancer diagnosis; breast density; breast imaging; clinical diagnostics; contrast enhanced; epidemiology study; follow-up; imaging modality; imaging study; in vivo; in vivo magnetic resonance spectroscopy; infiltrating duct carcinoma; malignant breast neoplasm; novel therapeutic intervention; patient population; recruit; saturated fat; spectroscopic imaging

PROJECT SUMMARY The role of fat in breast cancer development and growth has been studied extensively using body mass index, a measure of whole body fatness, and dietary fat intake in a number of epidemiological studies. However, there is a paucity of studies, on an individual level, to assess the role of breast fat itself in breast cancer due to lack of a non-invasive and fast measurement method. Since breast fibroglandular cells are surrounded by breast fat cells, the characteristics of breast fat may have a stronger relationship with breast cancer development, as supported by recent studies showing that a majority of breast cancer develops at the interface between fibroglandular tissue and adipose tissue. However, it is not trivial to study the role of breast fat, mainly due to the lack of a non-invasive and fast measurement method sensitive enough to important features of breast fat, such as types of fat. Recently, we have developed a rapid MRI method, referred to as Gradient-echo Spectroscopic Imaging (GSI), to measure fatty acid composition during clinical breast MRI exams. GSI can provide map of saturated fat and unsaturated fats in the breast adipose tissue without performing tissue biopsy. Our pilot study found that the postmenopausal women with aggressive breast cancer, known as invasive ductal carcinoma, have a significantly higher percentage of saturated fat in their breast adipose tissue than the postmenopausal women with only benign lesions. The overarching goal of this study is to determine the role of saturated fatty acid in breast cancer development and growth. In this proposal, we plan to use GSI for non-invasive in vivo measurement of saturated fat in the breast adipose tissue of postmenopausal women who undergo diagnostic breast MRI exams (Aims 1 and 2) or MRI-guided biopsy scans (Aim 3). Our central hypotheses are that (i) the breast saturated fatty acid fraction measured by GSI is associated with the presence of malignant lesions in the breast and (ii) the breast saturated fatty acid fraction correlates positively with inflammation in the breast adipose tissue that may lead to increase in estrogen production in adipocytes. The proposed study will evaluate whether breast saturated fat is an independent risk factor for breast cancer, and whether it can provide additional diagnostic information to current clinical diagnostic exams. In addition, the proposed imaging measure of breast saturated fat can be used to assess the efficacy of any intervention to reduce cancer-related inflammation in the breast adipose tissue and to investigate the possible role of fatty acid composition in prevention and clinical management of breast cancer.

项目总结