Gradient-Echo Spectroscopic Imaging Study of Saturated Fat and Breast Cancer

饱和脂肪与乳腺癌的梯度回波光谱成像研究

• 批准号: 10369734
• 负责人: Sungheon Gene Kim
• 金额: $ 41万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-02 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10369734
• 关键词: Adipocytes; Adipose tissue; Affect; Androgens; Benign; Biopsy; Biopsy Specimen; Body fat; Body mass index; Breast; Breast Cancer Risk Factor; Breast Magnetic Resonance Imaging; Cancer Etiology; Cells; Cessation of life; Characteristics; Clinical; Clinical Management; Contralateral Breast; Core Biopsy; Data; Dental crowns; Development; Diagnostic; Dietary Fats; Disease; Estrogens; Fatty Acids; Fatty acid glycerol esters; Goals; Gold; Growth and Development function; Hormonal; Image; Individual; Inflammation; Intake; Intervention; Investigation; Lead; Lesion; Link; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Mammographic screening; Maps; Measurement; Measures; Menopause; Methods; Monounsaturated Fatty Acids; Pathology; Patients; Pilot Projects; Polyunsaturated Fatty Acids; Postmenopause; Prevention; Production; Prognosis; Reporting; Risk Factors; Role; Sample Size; Saturated Fatty Acids; Scanning; Serum; Source; Spatial Distribution; Stains; Structure; Testing; Time; Tissues; Unsaturated Fats; Woman; aggressive breast cancer; breast cancer diagnosis; breast density; breast imaging; clinical diagnostics; contrast enhanced; epidemiology study; follow-up; imaging modality; imaging study; in vivo; in vivo magnetic resonance spectroscopy; infiltrating duct carcinoma; malignant breast neoplasm; novel therapeutic intervention; patient population; recruit; saturated fat; spectroscopic imaging

PROJECT SUMMARY The role of fat in breast cancer development and growth has been studied extensively using body mass index, a measure of whole body fatness, and dietary fat intake in a number of epidemiological studies. However, there is a paucity of studies, on an individual level, to assess the role of breast fat itself in breast cancer due to lack of a non-invasive and fast measurement method. Since breast fibroglandular cells are surrounded by breast fat cells, the characteristics of breast fat may have a stronger relationship with breast cancer development, as supported by recent studies showing that a majority of breast cancer develops at the interface between fibroglandular tissue and adipose tissue. However, it is not trivial to study the role of breast fat, mainly due to the lack of a non-invasive and fast measurement method sensitive enough to important features of breast fat, such as types of fat. Recently, we have developed a rapid MRI method, referred to as Gradient-echo Spectroscopic Imaging (GSI), to measure fatty acid composition during clinical breast MRI exams. GSI can provide map of saturated fat and unsaturated fats in the breast adipose tissue without performing tissue biopsy. Our pilot study found that the postmenopausal women with aggressive breast cancer, known as invasive ductal carcinoma, have a significantly higher percentage of saturated fat in their breast adipose tissue than the postmenopausal women with only benign lesions. The overarching goal of this study is to determine the role of saturated fatty acid in breast cancer development and growth. In this proposal, we plan to use GSI for non-invasive in vivo measurement of saturated fat in the breast adipose tissue of postmenopausal women who undergo diagnostic breast MRI exams (Aims 1 and 2) or MRI-guided biopsy scans (Aim 3). Our central hypotheses are that (i) the breast saturated fatty acid fraction measured by GSI is associated with the presence of malignant lesions in the breast and (ii) the breast saturated fatty acid fraction correlates positively with inflammation in the breast adipose tissue that may lead to increase in estrogen production in adipocytes. The proposed study will evaluate whether breast saturated fat is an independent risk factor for breast cancer, and whether it can provide additional diagnostic information to current clinical diagnostic exams. In addition, the proposed imaging measure of breast saturated fat can be used to assess the efficacy of any intervention to reduce cancer-related inflammation in the breast adipose tissue and to investigate the possible role of fatty acid composition in prevention and clinical management of breast cancer.

项目摘要 使用体重指数广泛研究了脂肪在乳腺癌发育和生长中的作用， 在许多流行病学研究中，全身肥胖和饮食脂肪摄入量的量度。然而， 在个人层面上，很少有研究评估乳腺脂肪本身在乳腺癌中的作用 缺乏无创和快速测量方法。由于乳腺纤维岩细胞被包围 乳腺脂肪细胞，乳腺脂肪的特征可能与乳腺癌具有更强的关系 最新研究的支持，开发表明，大多数乳腺癌在界面发展 在纤维结构组织和脂肪组织之间。但是，研究乳腺脂肪的作用并不小，主要是 由于缺乏对非侵入性和快速测量方法的敏感，足以对 乳房脂肪，例如脂肪类型。 最近，我们开发了一种快速MRI方法，称为梯度 - 回声光谱成像（GSI），， 在临床乳房MRI检查过程中测量脂肪酸组成。 GSI可以提供饱和脂肪和 乳房脂肪组织中的不饱和脂肪无需进行组织活检。我们的试点研究发现 侵略性乳腺癌的绝经后妇女，称为浸润性导管癌具有 绝经后妇女的乳房脂肪组织中饱和脂肪的百分比要高得多 只有良性病变。 这项研究的总体目标是确定饱和脂肪酸在乳腺癌发展中的作用 和增长。在此提案中，我们计划使用GSI用于非侵入性体内测量饱和脂肪 绝经后妇女的乳腺脂肪组织，他们接受诊断性乳房MRI检查（AIMS 1和2）或 MRI引导的活检扫描（AIM 3）。我们的中心假设是（i）乳房饱和脂肪酸的部分 通过GSI测量与乳房中存在恶性病变有关，（ii）乳房 饱和脂肪酸馏分与乳腺脂肪组织中的炎症正相关，这可能导致 脂肪细胞中雌激素产生的增加。 拟议的研究将评估乳房饱和脂肪是否是乳腺癌的独立危险因素， 以及是否可以为当前的临床诊断检查提供其他诊断信息。此外， 提出的乳腺饱和脂肪的成像度量可用于评估任何干预措施的功效 减少乳腺脂肪组织中与癌症相关的炎症，并研究脂肪的可能作用 乳腺癌预防和临床管理中的酸组成。