Technologies for Solid-State NMR Data Collection

固态核磁共振数据采集技术

• 批准号: 10323285
• 负责人: Chad M Rienstra
• 金额: $ 25.43万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-02 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10323285
• 关键词: Amplifiers; Back; Benchmarking; Calibration; Communities; Complex; Computer software; Data; Data Collection; Decision Making; Detection; Development; Disease; Ensure; Evaluation; Funding; Future; Generations; Goals; Hour; Illinois; Magic; Maintenance; Measurement; Minor; Modernization; Monitor; Multidimensional NMR Techniques; NMR Spectroscopy; Optics; Outcome; Output; Performance; Physiologic pulse; Procedures; Protocols documentation; Publishing; Ramp; Reproducibility; Research; Resolution; Sampling; Series; Signal Transduction; Specific qualifier value; Structure; System; Technology; Temperature; Time; TimeLine; Vendor; Width; automated algorithm; base; data acquisition; data exchange; design; experimental study; improved; instrument; instrumentation; interest; irradiation; magnetic field; open source; operation; radio frequency; repaired; solid state nuclear magnetic resonance

TR&D 2 SUMMARY The overall performance of the NMR spectrometer impacts every research sample and outcome. Often for complex multidimensional magic-angle spinning solid-state NMR experiments, dozens of experimental parameters require careful adjustment and must be readjusted anytime the environmental conditions drift. Here proposed are approaches to accelerate the setup and configuration of such experiments to maximally leverage the available instrument time, as well as to maintain performance over long periods of signal averaging that can be required for precious research samples that are available only in limited quantity. All aspects of the experimental performance also rely critically on the NMR probe designs, including the radiofrequency electronic circuits and related interfaces to spin the sample, control the temperature and deliver homogeneous pulsed magnetic fields as part of modern multidimensional NMR experiments.

Tr&d 2总结