Technologies for Solid-State NMR Data Collection

固态核磁共振数据采集技术

• 批准号: 10089601
• 负责人: Chad M Rienstra
• 金额: $ 24.63万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-02 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10089601
• 关键词: Amplifiers; Back; Benchmarking; Calibration; Communities; Complex; Computer software; Data; Data Collection; Decision Making; Detection; Development; Disease; Ensure; Evaluation; Funding; Future; Generations; Goals; Hour; Illinois; Magic; Maintenance; Measurement; Minor; Modernization; Monitor; Multidimensional NMR Techniques; NMR Spectroscopy; Optics; Outcome; Output; Performance; Physiologic pulse; Procedures; Protocols documentation; Publishing; Ramp; Reproducibility; Research; Resolution; Sampling; Series; Signal Transduction; Specific qualifier value; Structure; System; Technology; Temperature; Time; TimeLine; Vendor; Width; automated algorithm; base; data acquisition; data exchange; design; experimental study; improved; instrument; instrumentation; interest; irradiation; magnetic field; open source; operation; radio frequency; repaired; solid state nuclear magnetic resonance

TR&D 2 SUMMARY The overall performance of the NMR spectrometer impacts every research sample and outcome. Often for complex multidimensional magic-angle spinning solid-state NMR experiments, dozens of experimental parameters require careful adjustment and must be readjusted anytime the environmental conditions drift. Here proposed are approaches to accelerate the setup and configuration of such experiments to maximally leverage the available instrument time, as well as to maintain performance over long periods of signal averaging that can be required for precious research samples that are available only in limited quantity. All aspects of the experimental performance also rely critically on the NMR probe designs, including the radiofrequency electronic circuits and related interfaces to spin the sample, control the temperature and deliver homogeneous pulsed magnetic fields as part of modern multidimensional NMR experiments.

技术与发展 2 总结 核磁共振波谱仪的整体性能影响每个研究样本和结果。经常为 复杂的多维魔角旋转固态核磁共振实验，数十个实验 参数需要仔细调整，并且必须在环境条件发生变化时重新调整。这里 提出了加速此类实验的设置和配置的方法，以最大限度地利用 可用的仪器时间，以及在长时间的信号平均中保持性能 对于数量有限的珍贵研究样品可能需要。各方面的 实验性能还严重依赖于 NMR 探针设计，包括射频 用于旋转样品、控制温度并提供均匀的电子电路和相关接口 脉冲磁场作为现代多维核磁共振实验的一部分。