Investigating cognitive-motor variability to predict driving performance in stroke survivors with MCI

研究认知运动变异性以预测 MCI 中风幸存者的驾驶表现

• 批准号: 10322169
• 负责人: Neha Lodha
• 金额: $ 12.58万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10322169
• 关键词: Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Ankle; Automobile Driving; Behavioral; Blood Vessels; Clinical Data; Clinical Trials; Clinical Trials Design; Cognitive; Cognitive Science; Cognitive aging; Colorado; Complex; Computers; Data; Dementia; Development; Diagnosis; Early Diagnosis; Elderly; Elements; Executive Dysfunction; Exercise; Goals; Health; Impaired cognition; Impairment; Individual; International; Intervention; Investigation; Knowledge; Longevity; Measures; Mentors; Methodology; Modeling; Motor; Movement; Nervous System Trauma; Neurologic; Neurologist; Outcome; Participant; Performance; Process; Psychologist; Quality of life; Research; Research Personnel; Science; Stroke; Survivors; System; Technology; Testing; Time; Training; Universities; Work; age related; aging population; baby boomer; behavior measurement; career; cognitive development; cognitive performance; cognitive testing; experience; functional decline; functional disability; functional independence; impaired driving performance; improved; indexing; individual variation; innovation; interest; mild cognitive impairment; motor control; motor impairment; neglect; nervous system disorder; neurophysiology; novel; novel strategies; post stroke; pre-clinical; predictive marker; primary outcome; processing speed; professor; statistics; stroke survivor

PROJECT SUMMARY/ABSTRACT Dr. Neha Lodha is an Assistant Professor in the Department of Health and Exercise Science at Colorado State University (CSU). Dr. Lodha's long-term career goal is to become an independent investigator advancing the science of functional mobility to improve the quality of life in aging and age-related neurological disorders and dementias. Up to this point, Dr. Lodha has acquired strong scientific background in neurophysiology and motor control. To accomplish her career goal, a key additional element required is the training in cognitive sciences. Understanding how cognitive and motor systems interact to enable independent mobility is important for identifying the precise mechanisms and developing interventions to promote functional mobility. The short-term training goals of the current K01 application are to train in 1) conducting cognitive assessments with specific emphasis on the intra-individual variability (IIV) approach, 2) clinical trials design and analysis, 3) multivariate statistics, 4) driving technology, and 5) transition to independence. To achieve these goals, Dr. Lodha has assembled a mentoring team that consists of 1) an eminent gerontologist, Dr. Manfred Diehl (primary mentor) with expertise in aging, IIV and cognitive development across the lifespan, 2) an experimental psychologist, Dr. Karlene Ball (co-mentor) who is internationally renowned for her work in cognitive correlates of driving mobility in aging and dementia, 3) a vascular neurologist, Dr. Sharon Poisson (advisor) with extensive experience in clinical trials in stroke survivors, and 4) a renowned biostatistician, Dr. Haonan Wang (co-advisor) with experience in statistical inference and modeling for clinical data. The proposed research plan focuses on identifying the motor and cognitive impairments underlying driving deficits in older stroke survivors with mild cognitive impairment as they are most likely to resume on-road driving after stroke. Conventionally, driving impairments are shown to be independently influenced by mean-level performance in specific motor and cognitive domains. However, this mean-level approach neglects the well-established fact that performance becomes highly variable and unstable in older adults with neurological disorders, such as those at preclinical stages of Alzheimer's disease and mild cognitive imapirment. The proposed research will apply the novel intra- individual variability (IIV) approach to investigate driving mobility in older stroke survivors. The goal of the research plan is to identify the impact of stroke on IIV in motor and cognitive performance (Aim 1); determine the contribution of IIV measures to predict driving performance (Aim 2); and use IIV measures to predict change in driving performance over a two-year period (Aim 3). The training plan will accelerate Dr. Lodha's career to pursue a unique and independent line of research that combines cognitive and motor processes to promote the functional mobility of older adults and is directly aligned with NIA's AD/ADRD goal to identify sensitive behavioral measures for earliest manifestations of functional impairments in older adults.

项目摘要/摘要 Neha Lodha博士是科罗拉多州立大学健康与运动科学系的助理教授 大学(CSU)。洛达博士的长期职业目标是成为一名独立的调查员，推动 功能活动科学，以改善老龄化和老年相关神经疾病的生活质量 痴呆症。到目前为止，洛达博士已经在神经生理学和运动学方面获得了很强的科学背景。 控制力。要实现她的职业目标，一个关键的附加要素是认知科学方面的培训。 了解认知系统和运动系统如何相互作用以实现独立移动非常重要 确定精确的机制并制定干预措施，以促进功能流动。短期内 当前K01应用程序的培训目标是：1)进行认知评估 强调个体内变异(IIV)方法，2)临床试验设计和分析，3)多变量 统计，4)驾驶技术，5)向独立过渡。为了实现这些目标，洛达博士 组建了一个由1)著名老年病学家曼弗雷德·迪尔博士(主要导师)组成的指导团队 拥有在衰老、IIV和认知发展方面的专业知识，2)实验心理学家Dr。 卡琳·鲍尔(共同导师)，她因在驾驶机动性的认知关联方面的工作而享誉国际 在老龄化和痴呆症方面，3)血管神经学家，莎伦·泊松博士(顾问)，在以下领域拥有丰富的经验 中风幸存者的临床试验，以及4)著名的生物统计学家王浩南博士(联合顾问) 有临床数据的统计推断和建模经验。拟议的研究计划侧重于 确定轻度老年卒中幸存者潜在的运动和认知障碍 认知障碍，因为中风后他们最有可能恢复在公路上驾驶。按照惯例，开车 损伤被证明独立地受到特定运动和运动的平均水平表现的影响 认知域。然而，这种平均水平的方法忽略了一个公认的事实，即业绩 在患有神经系统疾病的老年人中变得高度可变和不稳定，例如那些处于临床前期的老年人 阿尔茨海默病和轻度认知障碍的各个阶段。拟议的研究将应用于新的内部- 个体变异性(IIV)方法研究老年中风幸存者的驾驶机动性。的目标是 研究计划是确定中风对运动和认知表现的IIV的影响(目标1)；确定 IIV措施对预测驾驶表现的贡献(目标2)；使用IIV措施预测#年的变化 在两年内推动业绩(目标3)。培训计划将加速Lodha博士的职业生涯 一条独特而独立的研究路线，结合认知和运动过程来促进 老年人的功能活动能力，并与NIA识别敏感行为的AD/ADRD目标直接一致 老年人功能障碍的最早表现的措施。