Investigating cognitive-motor variability to predict driving performance in stroke survivors with MCI

研究认知运动变异性以预测 MCI 中风幸存者的驾驶表现

• 批准号: 10834650
• 负责人: Neha Lodha
• 金额: $ 7.56万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10834650
• 关键词: Acceleration; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Automobile Driving; Behavioral; Blood Vessels; Clinical Data; Clinical Trials; Clinical Trials Design; Cognitive; Cognitive Science; Colorado; Dementia; Early Diagnosis; Elderly; Elements; Exercise; Goals; Health; Impaired cognition; International; Intervention; Investigation; Longevity; Measures; Mentors; Modeling; Motor; Neurologist; Performance; Process; Psychologist; Quality of life; Research; Research Personnel; Science; Stroke; System; Technology; Training; Universities; Work; age related; behavior measurement; career; cognitive development; cognitive performance; cognitive testing; experience; functional disability; functional independence; impaired driving performance; improved; individual variation; mild cognitive impairment; motor control; motor impairment; neglect; nervous system disorder; neurophysiology; novel; post stroke; pre-clinical; professor; statistics; stroke survivor

PROJECT SUMMARY/ABSTRACT Dr. Neha Lodha is an Assistant Professor in the Department of Health and Exercise Science at Colorado State University (CSU). Dr. Lodha's long-term career goal is to become an independent investigator advancing the science of functional mobility to improve the quality of life in aging and age-related neurological disorders and dementias. Up to this point, Dr. Lodha has acquired strong scientific background in neurophysiology and motor control. To accomplish her career goal, a key additional element required is the training in cognitive sciences. Understanding how cognitive and motor systems interact to enable independent mobility is important for identifying the precise mechanisms and developing interventions to promote functional mobility. The short-term training goals of the current K01 application are to train in 1) conducting cognitive assessments with specific emphasis on the intra-individual variability (IIV) approach, 2) clinical trials design and analysis, 3) multivariate statistics, 4) driving technology, and 5) transition to independence. To achieve these goals, Dr. Lodha has assembled a mentoring team that consists of 1) an eminent gerontologist, Dr. Manfred Diehl (primary mentor) with expertise in aging, IIV and cognitive development across the lifespan, 2) an experimental psychologist, Dr. Karlene Ball (co-mentor) who is internationally renowned for her work in cognitive correlates of driving mobility in aging and dementia, 3) a vascular neurologist, Dr. Sharon Poisson (advisor) with extensive experience in clinical trials in stroke survivors, and 4) a renowned biostatistician, Dr. Haonan Wang (co-advisor) with experience in statistical inference and modeling for clinical data. The proposed research plan focuses on identifying the motor and cognitive impairments underlying driving deficits in older stroke survivors with mild cognitive impairment as they are most likely to resume on-road driving after stroke. Conventionally, driving impairments are shown to be independently influenced by mean-level performance in specific motor and cognitive domains. However, this mean-level approach neglects the well-established fact that performance becomes highly variable and unstable in older adults with neurological disorders, such as those at preclinical stages of Alzheimer's disease and mild cognitive impairment. The proposed research will apply the novel intra- individual variability (IIV) approach to investigate driving mobility in older stroke survivors. The goal of the research plan is to identify the impact of stroke on IIV in motor and cognitive performance (Aim 1); determine the contribution of IIV measures to predict driving performance (Aim 2); and use IIV measures to predict change in driving performance over a two-year period (Aim 3). The training plan will accelerate Dr. Lodha's career to pursue a unique and independent line of research that combines cognitive and motor processes to promote the functional mobility of older adults and is directly aligned with NIA's AD/ADRD goal to identify sensitive behavioral measures for earliest manifestations of functional impairments in older adults.

项目总结/摘要 博士Neha Lodha是科罗拉多州立大学健康与运动科学系的助理教授 大学（CSU）。Lodha博士的长期职业目标是成为一名独立的研究人员， 功能性运动科学，以改善衰老和与年龄相关的神经系统疾病的生活质量， 痴呆症到目前为止，Lodha博士在神经生理学和运动方面拥有强大的科学背景。 控制为了实现她的职业目标，一个关键的额外因素是认知科学的培训。 了解认知和运动系统如何相互作用，以实现独立的移动性是很重要的， 确定确切的机制并制定干预措施，以促进职能流动。短期 当前K 01应用程序的培训目标是：1）进行认知评估， 强调个体内变异（IIV）方法，2）临床试验设计和分析，3）多变量 统计，4）驾驶技术，5）向独立过渡。为了实现这些目标，Lodha博士 组建了一个指导团队，由1）一位著名的老年病学家，曼弗雷德迪尔博士（主要导师） 他是一位实验心理学家，拥有衰老、IIV和整个生命周期的认知发展方面的专业知识。 Karlene Ball（共同导师），因其在驾驶机动性认知相关性方面的工作而享誉国际 3）血管神经学家Sharon Poisson博士（顾问），在衰老和痴呆方面具有丰富的经验， 中风幸存者的临床试验，和4）著名的生物统计学家，王浩南博士（共同顾问）， 临床数据的统计推断和建模经验。拟议的研究计划重点关注 在患有轻度脑卒中的老年脑卒中幸存者中， 认知障碍，因为他们最有可能在中风后恢复道路驾驶。传统上，驾驶 损伤被证明是独立的影响，平均水平的表现，在特定的电机和 认知领域然而，这种平均水平的方法忽略了一个公认的事实， 在患有神经系统疾病的老年人中，如临床前 阿尔茨海默病和轻度认知障碍的阶段。这项研究将采用新的内- 个体变异性（IIV）的方法来研究老年中风幸存者的驾驶活动性。的目标 研究计划是确定中风对运动和认知能力IIV的影响（目标1）;确定 IIV措施预测驾驶性能的贡献（目标2）;并使用IIV措施预测 在两年的时间里，驾驶性能（目标3）。培训计划将加速Lodha博士的职业生涯， 一个独特的和独立的研究路线，结合认知和运动过程，以促进 老年人的功能性活动，并与NIA的AD/ADRD目标直接一致，以确定敏感的行为 测量老年人功能障碍的早期表现。

项目成果

Increased temporal stride variability contributes to impaired gait coordination after stroke.

• DOI: 10.1038/s41598-022-17017-1
• 发表时间: 2022-07-25
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Patel, Prakruti;Enzastiga, Diana;Casamento-Moran, Agostina;Christou, Evangelos A.;Lodha, Neha
• 通讯作者: Lodha, Neha

Does the contribution of the paretic hand to bimanual tasks change with grip strength capacity following stroke?

• DOI: 10.1016/j.neuropsychologia.2022.108186
• 发表时间: 2022-04-15
• 期刊: NEUROPSYCHOLOGIA
• 影响因子: 2.6
• 作者: Pollet, Aviva K.;Patel, Prakruti;Lodha, Neha
• 通讯作者: Lodha, Neha