Effect of exercise modality during pregnancy on childhood obesity risk

孕期运动方式对儿童肥胖风险的影响

• 批准号: 10446148
• 负责人: Linda E May
• 金额: $ 66.23万
• 依托单位: EAST CAROLINA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10446148
• 关键词: Abdomen; Adult; Aerobic; Aerobic Exercise; Age; Age-Months; American College of Obstetricians and Gynecologists; Attenuated; Biological Markers; Birth; Birth Weight; Blood Pressure; Body fat; Body mass index; C-reactive protein; Cardiovascular Diseases; Child; Child Health; Childhood; Cholesterol; Conceptions; Control Groups; Data; Disease; Enrollment; Environment; Exercise; Exhibits; Gestational Diabetes; Goals; Growth; Guidelines; Habits; Health; Heart Rate; Hyperglycemia; Hyperinsulinism; Hyperlipidemia; Hypertension; Incidence; Infant; Infant Health; Inflammatory; Lead; Life; Lipids; Longitudinal Studies; Longitudinal prospective study; Low-Density Lipoproteins; Maternal Health; Measurement; Measures; Metabolic; Metabolic Diseases; Metabolic dysfunction; Metabolic syndrome; Methods; Morbidity - disease rate; Mothers; Motor; Obesity; Outcome; Overweight; Pathway interactions; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Pregnant Women; Public Health; Randomized; Randomized Controlled Trials; Recommendation; Research; Resistance; Risk; Risk Marker; Target Populations; Testing; Time; United States; Weight; Weight Gain; Woman; Work; antenatal; cardiometabolic risk; cardiometabolism; cardiovascular disorder risk; clinical practice; design; effective intervention; efficacious intervention; exercise intervention; exercise training; fetal; glucose metabolism; heart function; improved; improved outcome; in utero; infant outcome; innovation; insight; insulin sensitivity; intergenerational; maternal obesity; maternal weight; metabolomics; mode of exercise; mortality; next generation; obese mothers; obesity in children; obesity prevention; obesity risk; offspring; overweight child; prenatal; programs; recruit; resistance exercise; skills; treatment as usual

Project Abstract The in-utero environment, including maternal weight gain and exercise habits, can “program” a child towards disease or health after birth and into adulthood. The often-intergenerational cycle of obesity begins with a significant number of women who are overweight or obese (OW/OB) at the time of conception and throughout pregnancy; these women are more likely to give birth to infants who are macrosomic. By age 5, overweight (OW) children already have signs of metabolic syndrome and cardiovascular disease risks (e.g. obesity, hyperlipidemia, hyperglycemia, hyperinsulinemia, and hypertension). While research has demonstrated benefits of both aerobic and resistance exercise for pregnant women as well as decreased adiposity and improved motor/heart function in their infants, no studies have been done to determine which exercise modes are most beneficial for mother and baby when a woman is overweight or obese at the time of conception. For adults in general, combined aerobic and resistance exercise (AERE) delivers the greatest metabolic improvements (e.g. increased insulin sensitivity, improved heart function, decreased adiposity). Therefore, the purpose of this study is to identify which prenatal exercise type(s) will elicit the greatest positive impact on maternal and infant health while reducing metabolic risk markers in OW/OB pregnant women relative to non-exercising counterparts. Using a randomized design, 284 pregnant women will undergo an exercise intervention (AE, RE, AERE) from enrollment (~13-16 weeks gestation) until delivery (~40 weeks gestation). The central hypothesis of this study is that adding RE improves outcomes; thus, the COMBINATION of aerobic and resistance exercise not only will improve infant cardiometabolic health outcomes, as compared to AE alone, but will have the best compliance of all groups. We will test this hypothesis with two specific aims to: (1) Determine the influence of different exercise modes during OW/OB pregnancy on infant cardiometabolic health and growth trajectories; and (2) Determine the most effective exercise mode in OW/OB pregnancy on improving maternal cardiometabolic health. Methods will include measurements such as weight, abdominal circumference, blood pressure, lipids, and other biomarkers for both mothers and infants. The study will also track maternal and infant cardiometabolic outcomes through the post-partum period, up to 12 months. This work has the potential to impact clinical practice by revealing the earliest and most effective intervention to reduce the intergenerational cycle of metabolic dysfunction, including obesity, in women and children. .

项目摘要 宫内环境，包括母亲的体重增加和锻炼习惯，可能会对孩子产生影响 出生后和成年后的疾病或健康。肥胖症的代际循环通常始于 在怀孕期间和整个过程中超重或肥胖(OW/OB)的女性人数相当多 怀孕；这些妇女更有可能生下体型庞大的婴儿。到5岁时，超重(OW) 儿童已经有代谢综合征和心血管疾病风险的迹象(例如，肥胖， 高脂血症、高血糖、高胰岛素血症和高血压)。虽然研究已经证明了好处 对孕妇既进行有氧运动，又进行阻力运动，以及降低肥胖和改善肥胖 在婴儿的运动/心脏功能方面，还没有研究确定哪种运动方式最多 当女性在怀孕时超重或肥胖时，对母亲和婴儿有益。对于成年人来说， 综合有氧和耐力运动(AERE)可以提供最大的代谢改善(例如： 增加胰岛素敏感性，改善心脏功能，减少肥胖)。因此，这项研究的目的是 确定哪种产前锻炼类型(S)将对母婴健康产生最大的积极影响 同时，与不运动的孕妇相比，OW/OB孕妇的代谢风险标记物减少。vbl.使用 一项随机设计，284名孕妇将接受运动干预(AE，RE，AERE) 注册(~13-16周妊娠)，直到分娩(~40周妊娠)。这项研究的中心假设是 添加RE可以改善结果；因此，有氧运动和阻力运动的结合不仅将 改善婴儿心脏代谢健康结果，与单独使用AE相比，但将具有最好的依从性 所有小组。我们将用两个具体的目标来检验这一假设：(1)确定不同运动的影响 OW/OB孕期方式对婴儿心脏代谢健康和生长轨迹的影响；以及(2)确定 OW/OB孕期改善母体心脏代谢健康最有效的运动方式。方法 将包括体重、腹围、血压、血脂等测量 母亲和婴儿的生物标志物。这项研究还将跟踪母亲和婴儿的心脏代谢结果 在产后时期，最多12个月。这项工作有可能通过以下方式影响临床实践 揭示了最早和最有效的干预措施，以减少代际代谢周期 妇女和儿童的功能障碍，包括肥胖。 。