Optimizing the Use of Long-Acting Antiretrovirals for Youth Living withHIV

优化长效抗逆转录病毒药物对青少年艾滋病毒感染者的使用

基本信息

  • 批准号:
    10327146
  • 负责人:
  • 金额:
    $ 19.87万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-10 至 2025-08-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ ABSTRACT Youth with HIV and adherence struggles stand to benefit from long-acting antiretrovirals (LAARV), soon to be available in the U.S., more than other groups. Youth living with HIV between 13 and 29 years of age are less engaged in all steps of the HIV care cascade, resulting in exaggerated HIV-related disparities in health and an low rates of overall viral suppression in this group. Stigma, mental health issues, deficits in cognition and executive functioning, and obstacles within multiple categories of social determinants of health can hamper youths’ ability to sustain antiretroviral adherence and reap the benefits of this technology for themselves, their families, and their social networks and communities. The primary goal of this project, nested within the funded trial International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) 2022, is to develop an independent scholarly research program addressing the optimization of the use of LAARV in youth, with the ultimate goal of designing practical interventions to maximize their benefit. This four-year training and research program will consist of: 1) employing novel methods to understand the role of biopsychosocial and cognitive factors in the success of LAARV and potentially establish predictors of the efficacy of LAARV based on various pre-use characteristics in youth; 2) developing and piloting novel bioassays to enable in-the-field collections of Dried Blood Spot (DBS) or Dried Plasma Extractor (DPE) LAARV measurements for use in clinical trials or as therapeutic drug monitoring among YLHIV receiving LAARV; and 3) Learning and leveraging population PK modelling approaches to understand the sources of PK variability in YHIV on LAARV. The training will include formal coursework, direct mentoring, and guided practice-based experience with new methodologies in biostatistics, cognitive neuroscience, quantitative pharmacology and assay development, and advanced population pharmacokinetics. By gaining training from her mentors and collaborators in all these methods, Dr. Weld will establish herself as a clinician-researcher in long-acting infectious disease therapeutics equipped to assess new delivery strategies and technologies as they emerge, and capable of transforming her field. Results of the investigations conducted during the award period will establish a foundation for the subsequent design of interventional studies to improve HIV-related outcomes in youth with less-frequent dosing strategies, and submission of further funding proposals to support this line of inquiry.
项目摘要/摘要

项目成果

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Ethel Derby Weld其他文献

Ethel Derby Weld的其他文献

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{{ truncateString('Ethel Derby Weld', 18)}}的其他基金

Optimizing the Use of Long-Acting Antiretrovirals for Youth Living withHIV
优化长效抗逆转录病毒药物对青少年艾滋病毒感染者的使用
  • 批准号:
    10487556
  • 财政年份:
    2021
  • 资助金额:
    $ 19.87万
  • 项目类别:
Optimizing the Use of Long-Acting Antiretrovirals for Youth Living withHIV
优化长效抗逆转录病毒药物对青少年艾滋病毒感染者的使用
  • 批准号:
    10679087
  • 财政年份:
    2021
  • 资助金额:
    $ 19.87万
  • 项目类别:

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