Plug-And-Play Cochlear Electrode Array - Diversity Supplement.

即插即用耳蜗电极阵列 - 多样性补充。

• 批准号: 10328845
• 负责人: angelique johnson
• 金额: $ 1.29万
• 依托单位: MEMSTIM, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-15 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10328845
• 关键词: 3D Print; Address; Area; Biological; Categories; Cochlea; Cochlear Implants; Devices; Electrodes; Hand; Hearing Aids; Lasers; Length; Mechanics; Metals; Microfabrication; Miniaturization; Modulus; Music; Nature; Nerve Tissue; Otolaryngology; Output; Play; Printing; Resolution; Shapes; Silicones; Slide; Spinal Cord; Technology; Testing; Thick; biomaterial compatibility; cost; deep brain stimulator; design; elastomeric; falls; hearing impairment; improved; manufacturing process; millimeter; new technology; novel; parent grant; pre-clinical; speech recognition

Project Summary/Abstract Worldwide, approximately 466 million people suffer from disabling hearing loss. When conventional hearing aids provide no appreciable benefit, cochlear implants are a solution. Current cochlear implants, while beneficial in their use, are limited in their capabilities by hand-assembly of wire-bundled electrode arrays. Hand assembly is very costly, extremely labor-intensive, and inadequate in implementing new strategies in Otolaryngology for improving speech recognition and music appreciation. MEMStim LLC proposes a plug-and-play advanced-manufacturing solution that relies heavily on 3D printing. By printing conductive and nonconductive silicones, biocompatible pluggable arrays can be printed to any size, length, shape or thickness, from several microns to tens of millimeters. Most importantly, the integrated connectors plug readily onto stimulators by way of a novel micro-socket technology. The micro-sockets are compatible and slide right onto the feedthrough pins. The printer resolution can output pluggable connectors that are compatible with pin-to-pin pitches smaller than 100 μm (edge-to-edge), allowing for enhanced miniaturization. The 3D printed soft elastomeric arrays differ from wire-bundle cochlear implants in that they are less stiff and more susceptible to small changes in strain [add reference?]. They fall within a category of devices called “bioelectronics”, which have a Young’s Modulus (100 Pa-10MPa) in the range of most biological matter such as nerve tissue. Due to this difference, the candidate will strengthen our case to the FDA and cochlear manufacture’s themselves by conducting further electrical and mechanical tests to prove the functionality and durability under strain. The tests will also help us better understand the durability and reliability limits of our plug-and-play arrays for other neurostimulator application areas, such as spinal cord stimulators and deep brain stimulators.

项目摘要/摘要 在全球范围内，约有4.66亿人患有致残性听力损失。当常规听证 艾滋病没有提供明显的好处，人工耳蜗术是一种解决方案。目前的人工耳蜗术，虽然 对于它们的使用是有益的，但由于手工组装成线束电极阵列，其能力有限。手 组装成本非常高，劳动密集度极高，而且在实施新战略方面还不够充分 提高语音识别和音乐鉴赏力的耳鼻喉科。 MEMSTim LLC提出了一种高度依赖3D打印的即插即用先进制造解决方案。 通过印刷导电和非导电有机硅，生物兼容的可插拔阵列可以被印刷成任何尺寸， 长度、形状或厚度，从几微米到几十毫米。最重要的是，集成的 通过一种新的微插座技术，连接器可以很容易地插入刺激器。微型插座是 兼容并向右滑动到馈通针脚上。打印机分辨率可以输出可插拔接口 兼容小于100μm(边到边)的管脚到管脚间距，允许增强 小型化。 3D打印软弹性体阵列不同于钢丝束人工耳蜗植入物，因为它们更少 僵硬，更容易受到菌株微小变化的影响[添加参考？]。它们属于以下类别 被称为“生物电子学”的器件，其杨氏模数(100帕-10兆帕)在 生物物质，如神经组织。由于这一差异，候选人将加强我们的理由 FDA和耳蜗制造商自己通过进一步的电气和机械 测试以证明在压力下的功能性和耐用性。这些测试也将帮助我们更好地 了解我们用于其他神经刺激器的即插即用阵列的耐用性和可靠性极限 应用领域，如脊髓刺激器和脑深部刺激器。