Stress Mental Disorders Accelerated Aging and Dementia a 35 year Cohort Study - Covid Supplement
压力性精神障碍加速衰老和痴呆症 35 年队列研究 - Covid Supplement
基本信息
- 批准号:10327561
- 负责人:
- 金额:$ 81.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-01 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:African AmericanAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease riskAlzheimer’s disease biomarkerAnxiety DisordersBaltimoreBloodCDKN2A geneCatchment AreaCell AgingCognitionCognitiveCohort StudiesCross-Sectional StudiesDataData CollectionDementiaDepressive disorderDiagnosisDiagnosticDiseaseElderlyEpidemiologyEpigenetic ProcessEventExposure toFollow-Up StudiesGene-ModifiedHealthImpaired cognitionInflammationInterviewKnowledgeLeadLifeLinkLongitudinal StudiesMeasuresMediatingMediator of activation proteinMedicalMental DepressionMental disordersMethodologyMethylationModificationMorbidity - disease rateNeuropsychological TestsOutcomeParticipantPatient Self-ReportProspective StudiesRecording of previous eventsRiskRisk FactorsSamplingSiteStressStructureTelomere ShorteningWristactigraphyadjudicateagedanxiety symptomsbasecohortcoronavirus diseasedepressive symptomsdisabilityfunctional declinefunctional disabilityfunctional outcomesgenome wide association studymild cognitive impairmentmodifiable risknovelpoor sleeppreventrisk variantstressortrauma exposure
项目摘要
Numerous studies demonstrate links between depressive symptoms or disorders and poor cognitive and
functional outcomes. Anxiety symptoms and disorders, poor sleep, and stressful life events are common and
correlated with depression, but little is known about their association with cognitive and functional decline, such
as occurs in Alzheimer’s disease (AD). These stress-related exposures are also associated with medical
morbidity and disability, but the mechanisms linking them to poor health outcomes are unclear. Cross-sectional
studies suggest that these exposures might lead to these outcomes by hastening cellular aging, measured by
shortening of telomeres. Prospective studies in cohorts with well-characterized histories of stress-related
exposures and repeated measures of cellular aging are needed to investigate this possibility. We propose to
analyze these issues using data already collected in the Baltimore Epidemiologic Catchment Area (ECA)
Followup Study cohort, adding another wave of data collection. The Baltimore ECA Study began collecting
structured diagnostic interview data on depressive and anxiety disorders in 1981 in a representative sample of
East Baltimore residents, and did so over three additional waves, most recently in 2004 (Wave 4). In addition
to measures of anxiety and depressive symptoms and disorders, the diverse (35% African American) ECA
cohort has completed repeated measures of poor sleep, life stressors, trauma exposure, cognition, and
functional impairment. In 2004, when all participants were aged ≥40 years, they donated blood and buccal
samples. All ECA subjects are now aged ≥50 (estimated mean = 68, range 52-96). We will locate and interview
an estimated 601 participants from Wave 4, repeating structured diagnostic interview assessment of mental
disorders, and measuring life stressors, trauma exposure, and poor sleep by both self-report and wrist
actigraphy. Participants will complete neuropsychological tests and functional measures, and will again donate
blood and buccal samples. This will enable us to determine the association of 35-year histories of stress-
related exposures, from mid to later life, with cognitive and functional decline, adjudicated mild cognitive
impairment and dementia diagnoses, including probable and possible AD, and biomarkers of cellular aging:
shortening of telomeres and increases in p16ink4a levels from 2004 to 2016. We will also determine if these
exposures are associated with epigenetic modification of genes in the ECA that we select based on novel
genome-wide association and methylation analyses we will conduct in existing data from the Baltimore
Longitudinal Study of Aging (BLSA) and the InCHIANTI cohorts. We will examine whether methylation of these
candidate sites, and measures of inflammation (measured in blood in 2004 and 2016) in the ECA, mediate
hypothesized predictive associations in the ECA cohort. Results will clarify the link between stress-related
exposures from mid to later life and aging-related outcomes, advance knowledge of mechanisms linking these
exposures to disease and disability, and provide clues to avenues for preventing these outcomes.
大量研究表明抑郁症状或疾病与认知能力差和认知能力差之间存在联系。
功能结果。焦虑症状和障碍、睡眠质量不佳以及生活压力事件很常见,
与抑郁症相关,但人们对它们与认知和功能下降的关系知之甚少,例如
正如阿尔茨海默病 (AD) 中所发生的那样。这些与压力相关的暴露也与医疗有关
发病率和残疾,但将其与不良健康结果联系起来的机制尚不清楚。横截面
研究表明,这些暴露可能通过加速细胞衰老而导致这些结果,通过测量
端粒缩短。对具有明确的压力相关史的队列进行前瞻性研究
需要暴露和重复测量细胞老化来研究这种可能性。我们建议
使用巴尔的摩流行病学集水区 (ECA) 已收集的数据分析这些问题
后续研究队列,增加了另一波数据收集。巴尔的摩 ECA 研究开始收集
1981 年抑郁症和焦虑症的结构化诊断访谈数据,代表性样本为
东巴尔的摩居民,并在另外三波中这样做了,最近一次是在 2004 年(第四波)。此外
为了衡量焦虑和抑郁症状和障碍,多样化的(35% 非洲裔美国人)ECA
队列已完成对睡眠不佳、生活压力源、创伤暴露、认知和
功能障碍。 2004年,当所有参与者年龄≥40岁时,他们捐献了血液和口腔
样品。所有 ECA 受试者现年龄均≥ 50 岁(估计平均值 = 68,范围 52-96)。我们将寻找并采访
第 4 波中估计有 601 名参与者,重复结构化诊断访谈评估心理状况
疾病,并通过自我报告和手腕测量生活压力源、创伤暴露和睡眠质量差
体动记录仪。参与者将完成神经心理学测试和功能测量,并将再次捐赠
血液和口腔样本。这将使我们能够确定 35 年压力历史之间的关联
从中年到晚年的相关暴露,伴随认知和功能下降,判定为轻度认知
损伤和痴呆症诊断,包括可能和可能的 AD,以及细胞衰老的生物标志物:
从 2004 年到 2016 年,端粒缩短,p16ink4a 水平增加。我们还将确定这些是否
暴露与 ECA 中基因的表观遗传修饰有关,我们根据新的选择
我们将在巴尔的摩的现有数据中进行全基因组关联和甲基化分析
衰老纵向研究 (BLSA) 和 InCHIANTI 队列。我们将检查这些是否甲基化
ECA 中的候选部位和炎症测量(2004 年和 2016 年在血液中测量)介导
ECA 队列中假设的预测关联。结果将阐明压力相关之间的联系
从中年到晚年的暴露和与衰老相关的结果,可以增进对将这些联系起来的机制的了解
暴露于疾病和残疾的情况,并提供预防这些结果的途径线索。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The serotonin transporter gene polymorphism (SLC6A4) and risk for psychiatric morbidity and comorbidity in the Baltimore ECA follow-up study.
- DOI:10.1016/j.comppsych.2020.152199
- 发表时间:2020-10
- 期刊:
- 影响因子:7.3
- 作者:Miozzo R;Eaton WW;Joseph Bienvenu O 3rd;Samuels J;Nestadt G
- 通讯作者:Nestadt G
Job strain and cognitive change: the Baltimore Epidemiologic Catchment Area follow-up study.
工作压力和认知变化:巴尔的摩流行病学区域随访研究。
- DOI:10.1136/oemed-2018-105213
- 发表时间:2018-12
- 期刊:
- 影响因子:4.9
- 作者:Dong L;Eaton WW;Spira AP;Agnew J;Surkan PJ;Mojtabai R
- 通讯作者:Mojtabai R
Specific phobias.
- DOI:10.1016/s2215-0366(18)30169-x
- 发表时间:2018-08
- 期刊:
- 影响因子:0
- 作者:Eaton WW;Bienvenu OJ;Miloyan B
- 通讯作者:Miloyan B
Association of Psychotic Experiences and Incident Depression in a Longitudinal Population-Based Community Survey.
- DOI:10.1176/appi.prcp.20220021
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Rodriguez, Katrina M;Sharifi, Vandad;Eaton, William W
- 通讯作者:Eaton, William W
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WILLIAM W EATON其他文献
WILLIAM W EATON的其他文献
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{{ truncateString('WILLIAM W EATON', 18)}}的其他基金
Confirmatory Double-Blind Placebo-Controlled Efficacy Trial of a Gluten-Free Diet in a Subgroup of Persons with Schizophrenia Who Have High Levels of IgG Anti-Gliadin Antibodies
对具有高水平 IgG 抗麦醇溶蛋白抗体的精神分裂症患者亚组进行无麸质饮食的验证性双盲安慰剂对照疗效试验
- 批准号:
10217976 - 财政年份:2017
- 资助金额:
$ 81.87万 - 项目类别:
Confirmatory Double-Blind Placebo-Controlled Efficacy Trial of a Gluten-Free Diet in a Subgroup of Persons with Schizophrenia Who Have High Levels of IgG Anti-Gliadin Antibodies
对具有高水平 IgG 抗麦醇溶蛋白抗体的精神分裂症患者亚组进行无麸质饮食的验证性双盲安慰剂对照疗效试验
- 批准号:
10001815 - 财政年份:2017
- 资助金额:
$ 81.87万 - 项目类别:
Stress Mental Disorders Accelerated Aging and Dementia a 35 year Cohort Study
压力性精神障碍加速衰老和痴呆症 35 年队列研究
- 批准号:
9344528 - 财政年份:2016
- 资助金额:
$ 81.87万 - 项目类别:
Stress Mental Disorders Accelerated Aging and Dementia a 35 year Cohort Study
压力性精神障碍加速衰老和痴呆症 35 年队列研究
- 批准号:
10160389 - 财政年份:2016
- 资助金额:
$ 81.87万 - 项目类别:
Stress Mental Disorders Accelerated Aging and Dementia a 35 year Cohort Study
压力性精神障碍加速衰老和痴呆症 35 年队列研究
- 批准号:
9516868 - 财政年份:2016
- 资助金额:
$ 81.87万 - 项目类别:
Stress Mental Disorders Accelerated Aging and Dementia a 35 year Cohort Study
压力性精神障碍加速衰老和痴呆症 35 年队列研究
- 批准号:
9930377 - 财政年份:2016
- 资助金额:
$ 81.87万 - 项目类别:
Development for RCT of Gluten Free Diet in Gliadin-Positive Schizophrenia
麦醇溶蛋白阳性精神分裂症无麸质饮食随机对照试验的发展
- 批准号:
8877631 - 财政年份:2013
- 资助金额:
$ 81.87万 - 项目类别:
Development for RCT of Gluten Free Diet in Gliadin-Positive Schizophrenia
麦醇溶蛋白阳性精神分裂症无麸质饮食随机对照试验的发展
- 批准号:
8692023 - 财政年份:2013
- 资助金额:
$ 81.87万 - 项目类别:
Development for RCT of Gluten Free Diet in Gliadin-Positive Schizophrenia
麦醇溶蛋白阳性精神分裂症无麸质饮食随机对照试验的发展
- 批准号:
8529823 - 财政年份:2013
- 资助金额:
$ 81.87万 - 项目类别:
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