National Cancer Institute (NCI) Cancer Clinical Investigator Team Leadership Award (CCITLA) P30 Administrative Supplement for Fiscal Year (FY) 2021

范德比尔特-英格拉姆癌症中心 项目摘要/摘要 这是范德比尔特-英格拉姆癌症中心第五次竞争性续签癌症中心支持赠款(CCSG) 中心(VICC)。VICC是范德比尔特大学医学中心和范德比尔特大学的矩阵中心 整合了医学、护理、艺术和医学学院与癌症相关的专业知识和资源 科学和工程、皮博迪教育学院和完全整合的退伍军人管理局 医疗中心。主要的临床设施和大部分的研究设施都位于一个校园内， 它促进非正式互动、资源共享和富有成效的合作。成立于1993年， VICC作为一个具有跨部门地位的组织单位发挥作用。VICC-具体职责和 目标是1)开展、支持和加强最先进的、多学科的基础、临床和人口- 以研究为基础；2)协调和整合整个范德比尔特与癌症有关的活动，并与 我们的地方、地区、国家和全球合作伙伴；3)培训和开发下一代癌症 调查人员、癌症领导者和癌症护理提供者的连续体；以及4)评估和确定优先顺序 并利用伙伴关系通过癌症研究、护理和治疗来满足这些需求 控制活动。研究、培训、社区推广和参与的目标已经实现 通过CCSG和机构支持的组织能力、规划和评估，以及八个 研究项目。VICC研究项目是信号转导和细胞增殖、基因组 维持、宿主-肿瘤相互作用、胃肠癌、翻译研究和干预 肿瘤学，乳腺癌，癌症流行病学，癌症健康结果和控制。11个人共享 建议的资源都是以前支持的。VICC的显著增长和科学发现 在过去的项目期内，产生了22项新的多名调查员补助金，共计71项，以及8项新的培训补助金 总共26个。此外，还成功地更新了两个NCI孢子。有了这些和其他许多NCI的拨款， 同行评审的资金增加了35%。在精确肿瘤学方面取得了重大成就， 癌症流行病学、健康结果和控制、基因组学、抗癌药物发现、早期发现和 预防和癌症差异研究。增加VICC空间和设施，以及慈善和 机构资金，支持招聘67名新教师，他们加入了一个执行VICC的专门团队 使命：通过开创性研究减少癌症死亡和痛苦；创新以患者为中心的护理； 以及循证预防、教育和社区倡议。VICC高级领导层提供有效的 监督和催化创新和范式转变的科学，从而为我们的患者和 我们在我们的流域服务的社区，并减轻了全国和全球的癌症负担。

VANDERBILT-INGRAM CANCER CENTER OVERALL PROJECT SUMMARY/ABSTRACT This is the fifth competing renewal of the Cancer Center Support Grant (CCSG) at Vanderbilt-Ingram Cancer Center (VICC). VICC is a matrix center within Vanderbilt University Medical Center and Vanderbilt University that integrates the cancer-related expertise and resources of the Schools of Medicine, Nursing, Arts and Sciences and Engineering, the Peabody School of Education and the fully integrated Veterans Administration Medical Center. The major clinical facilities and the majority of research facilities are located on one campus, which promotes informal interactions, sharing of resources and productive collaborations. Established in 1993, VICC functions as an organizational unit with a supra-departmental status. VICC-specific responsibilities and aims are 1) to conduct, support and enhance state-of-the-art, multidisciplinary basic, clinical and population- based research; 2) to coordinate and integrate cancer-related activities across Vanderbilt and to collaborate with our local, regional, national and global partners; 3) to train and develop the next generation of cancer investigators, cancer leaders and the continuum of cancer care providers; and 4) to assess and prioritize community needs and to leverage partnerships to address those needs through cancer research, care and control activities. The research, training, and community outreach and engagement objectives are accomplished through CCSG and institutionally supported organizational capabilities, planning and evaluation, and eight research programs. The VICC Research Programs are Signal Transduction and Cell Proliferation, Genome Maintenance, Host-Tumor Interactions, Gastrointestinal Cancer, Translational Research and Interventional Oncology, Breast Cancer, Cancer Epidemiology, and Cancer Health Outcomes and Control. Eleven shared resources are proposed, all previously supported. Remarkable VICC growth and scientific discovery over the past project period has led to 22 new multi-investigator grants for a total of 71, and 8 new training grants for a total of 26. In addition, two NCI SPOREs were successfully renewed. With these and many other NCI grants, peer-reviewed funding increased 35%. Significant accomplishments have been made in precision oncology, cancer epidemiology, health outcomes and control, genomics, cancer drug discovery, early detection and prevention, and cancer disparities research. Increased VICC space and facilities, along with philanthropic and institutional funds, supported the recruitment of 67 new faculty, who join a dedicated team carrying out the VICC mission: to alleviate cancer death and suffering through pioneering research; innovative patient-centered care; and evidence-based prevention, education and community initiatives. VICC senior leadership provides effective oversight and catalyzes innovative and paradigm-shifting science that translates to benefit for our patients and the community we serve in our catchment and reduces the burden of cancer nationally and globally.