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Atopic dermatitis in an urban adult population: identifying the role of social and environmental factors

城市成年人中的特应性皮炎：确定社会和环境因素的作用

基本信息

批准号：
10340831
负责人：
Junko Takeshita
金额：
$ 71.76万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10340831
关键词：
Address Adult Affect Air Atopic Dermatitis Behavior Behavioral Biology Black race Child Childhood Chronic Disease Communities Complex Data Dermatologist Development Diabetes Mellitus Disease Emotional Environmental Epidemiology Environmental Risk Factor Epidemiology Ethnic Origin Ethnic group Future Genetic Geographic Locations Health Heart Diseases Hispanic Housing Hypertension Impairment Individual Intervention Interview Knowledge Left Longitudinal cohort Longitudinal cohort study Measures Mediation Mediator of activation protein Medical Methods Modeling Neighborhoods Outcome Pennsylvania Persons Philadelphia Population Prevalence Quality of life Race Regimen Reporting Research Design Research Methodology Research Personnel Role Severities Skin Care Smoking History Social support Statistical Data Interpretation Structure Surveys Urban Population Work base burden of illness chronic inflammatory disease cohort contextual factors design disparity elimination ethnic difference ethnic diversity experience future implementation health care service utilization health related quality of life improved innovation medically underserved medically underserved population novel psychosocial racial and ethnic racial and ethnic disparities racial diversity skin disorder social social factors socioeconomic disadvantage

项目摘要

ABSTRACT Atopic dermatitis (AD) is a common, chronic inflammatory disease of the skin that affects 10% of adults. AD is associated with major health-related quality-of-life (QoL) and psychosocial impairments that exceed those of other serious chronic diseases such as heart disease, diabetes, and hypertension. Despite the major physical and emotional burdens that accompany AD, it remains an understudied skin disease among adults because, until recently, AD had been incorrectly considered a childhood disease that remits in adulthood. Importantly, our preliminary data reveal racial/ethnic differences in the severity of, QoL impact of, and health care utilization for AD that suggest the presence of disparities in AD outcomes that deserve further study. Considering the anticipated diversification of the U.S. population, such disparities are only expected to worsen if left unaddressed. However, a critical barrier to identifying, understanding, and ultimately eliminating racial/ethnic disparities in AD outcomes among adults exists due to the lack of adult AD cohorts with sufficient racial/ethnic diversity and individual-level social and environmental contextual data that are necessary to comprehensively evaluate the causes of such disparities. In order to address this barrier, we propose to create a cohort of racially and ethnically diverse adults with AD within the socioeconomically disadvantaged and medically underserved, urban neighborhood of North Philadelphia, Pennsylvania. North Philadelphia adult residents represent a population that is vulnerable to a large burden of AD. With this cohort, we aim to perform a longitudinal cohort study to: i) confirm and further characterize existing racial/ethnic disparities in AD outcomes and health care utilization for AD among adults, and ii) identify the individual behavioral, social, and environmental contextual factors that simultaneously contribute to racial/ethnic disparities in AD outcomes. We will address these aims utilizing a novel transdisciplinary approach and a sequential mixed methods study design in order to incorporate the lived experience of adults with AD in our studies. We hypothesize that specific and potentially modifiable behavioral, social, and environmental factors contribute to racial/ethnic disparities in AD outcomes. The new knowledge that will be gained from the proposed work is essential to informing future individual- and community-level interventions to reduce racial/ethnic disparities and improve AD outcomes among similar urban adult populations.

摘要