Center for Lung Biology and Disease

摘要 该提案的目标是建立肺部疾病卓越中心 (COE) 这是高度互动的，由一群充满活力的初级研究人员组成，他们的研究重点是 是在了解与相关的分子和细胞免疫机制 病机若有肺病。有前途的初级研究者 (PJI) 提出了四项建议 独立但互补的研究项目将使用分子、免疫学和 研究小鼠和非人类灵长类动物模型中肺部疾病的病理学方法。他们 还将使用去识别化的人类样本来验证他们在临床前模型中的发现。我们会 确定宿主信号分子，如IDO、ITK、IL4Rα和TTP在启动过程中的作用 对传染性（细菌/病毒）和非传染性物质（过敏原）的保护性宿主免疫反应。 长期目标是建立一个协作的、富有成效的、可持续的、 国内/国际公认的肺部疾病研究 COE。具体目标是：1. 促进建立国家/国际认可的肺部疾病 COE。 在路易斯安那州立大学的支持下，这个由 COBRE 资助的中心将确保肺部疾病研究 该小组是可持续的，并将提供急需的资源来扩大这一研究领域 主要由路易斯安那州支持； 2. 促进研究的改进 增强外部赠款竞争力的基础设施。除了现有的核心 通过 NIGMS 资助的 COBRE-III、INBRE 和路易斯安那临床和转化中心提供设施 （LA CatTS）在巴吞鲁日，我们将建立两个科学核心，例如肺 免疫病理学和分子生物学。我们还将把办公空间改造为传统的 动物饲养室和设备室，为 COBRE 调查人员提供专用套件。我们会 在2-3年内招募2名具有互补研究领域的PJI，并为整个COBRE-I招募6名PJI 持续时间。路易斯安那州立大学兽医学院 (SVM) 已承诺购买新的 设备、提供服务合同，COBRE 将为科学和技术人员提供工资 工作人员； 3. 发展行政基础设施以促进 PJI 的独立职业生涯。 我们聚集了具有杰出业绩的资深科学家，为内部科学部门服务 顾问委员会 (ISAC)、外部顾问委员会 (EAB) 和指导委员会 (MC) 将仔细评估每个 PJI 的科学需求，并根据情况量身定制指导计划 个人的需要。两名导师：一名本地导师（巴吞鲁日）和一名路易斯安那州立大学外部导师（路易斯安那州） 分配的。 PJI 将参加职业发展研讨会并参加道德和 科学写作。我们将提名 PJI 参加 NIH/CSR 早期职业资助评审员计划。我们 还将协助 PJI 向 ISAC、EAB 和 MC 进行演示，寻求他们对自己的计划的反馈 补助金提交。这里聚集的团队与研究目标非常匹配， 肺免疫学、多学科领域的互补专业知识，并拥有丰富的生产历史 合作。该 COBRE 计划将为破坏性的发病机制提供新的见解 指导未来治疗和预防这些及其他肺部疾病的改进策略 人群中的疾病。

ABSTRACT The objective of this proposal is to establish a Center of Excellence (COE) in Pulmonary Diseases that is highly interactive and consists of a dynamic group of junior investigators whose research focus is on understanding the molecular and cellular immunological mechanisms associated with the pathogenesis if lung diseases. The Promising Junior Investigators (PJIs) have proposed four independent but complementary research projects that will use molecular, immunological, and pathological approaches to investigate lung diseases in mouse and non-human primate models. They will also use de-identified human samples to validate their findings from preclinical models. We will determine the host signaling molecules, such as IDO, ITK, IL4Rand TTP in the initiation of protective host immune responses to infectious (bacterial/viral) and non-infectious agents (allergens). The long-term goal is to establish a collaborative, productive, sustainable, and nationally/internationally recognized COE in Pulmonary Disease research. The Specific Aims are: 1. To promote the establishment of a nationally/internationally recognized COE in Pulmonary Diseases. With the support of LSU, this COBRE-funded center will ensure that the pulmonary disease research group is sustainable and will provide much-needed resources to expand this research area which is primarily supported by the state of Louisiana; 2. To facilitate the improvement in research infrastructure for enhancing competitiveness for extramural grants. In addition to existing core facilities through NIGMS-funded COBRE-III, INBRE, and Louisiana Clinical and Translational Center (LA CaTS) in Baton Rouge, we will establish two scientific cores, such as Pulmonary Immunopathology and Molecular Biology. We will also renovate the office spaces into conventional animal holding and equipment rooms to have a dedicates suite for COBRE investigators. We will recruit 2 PJIs with complementary research areas in 2-3 years and 6 PJIs for the entire COBRE-I duration. The LSU School of Veterinary Medicine (SVM) has committed to purchase of new equipment, provide service contracts and the COBRE will offer salaries to scientific and technical staff; and 3. To develop an administrative infrastructure to promote the independent career of PJIs. We have assembled senior scientists with outstanding track record to serve on the Internal Scientific and advisory committee (ISAC), external advisory board (EAB), and mentoring committee (MC) that will carefully evaluate scientific needs of each PJI and tailor the mentoring plan based on the individual’s need. Two mentors: one local (Baton Rouge) and one outside LSU (Louisiana) have been assigned. The PJIs will attend career development workshops and will participate in ethics and scientific writing. We will nominate PJIs for the NIH/CSR Early Career Grant Reviewer program. We will also assist PJIs with their presentations to the ISAC, EAB, and MC to seek their feedback on their grants submissions. The team assembled here is exceptionally matched to the research goals, complementary expertise in lung immunology, multidisciplinary, and has a solid history of productive collaboration. This COBRE program will provide novel insights into the pathogenesis of devastating lung diseases that guide future improved strategies to treating and preventing these and other lung diseases in human population.