Center for Lung Biology and Disease

肺生物学与疾病中心

• 批准号: 10588205
• 负责人: TAMMY R DUGAS
• 金额: $ 223.6万
• 依托单位: LOUISIANA STATE UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-02 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10588205
• 关键词: Acceleration; Acute Lung Injury; Advisory Committees; Allergens; Alveolar Macrophages; Animals; Antigen-Antibody Complex; Area; Award; Basic Science; Biology; Biomedical Research; Cells; Centers of Research Excellence; Clinical; Collaborations; Contract Services; Core Facility; Dedications; Development; Discipline; Disease; Economic Development; Educational workshop; Ensure; Environment; Equipment; Ethics; Extramural Activities; Extrinsic asthma; Feedback; Fostering; Funding; Future; Goals; Grant; Human; Immune response; Immunologics; Immunology; Individual; Infectious Diseases Research; Influenza; Infrastructure; Institution; Interdisciplinary Study; International; Life; Louisiana; Lung; Lung diseases; Mentored Research Scientist Development Award; Mentors; Modeling; Molecular; Molecular Biology; Mus; National Institute of General Medical Sciences; Pathogenesis; Pathologic; Phase; Population; Pre-Clinical Model; Process; Productivity; Pulmonary Inflammation; Recording of previous events; Records; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Respiratory Disease; Sampling; Senior Scientist; Signaling Molecule; Solid; Stimulus; Strategic Planning; T-Lymphocyte Subsets; Tuberculosis; United States National Institutes of Health; Universities; Veterinary Medicine; Veterinary Schools; Viral; Wages; Writing; career; career development; design; eosinophil; experience; immune function; immunopathology; improved; innovation; insight; interest; multidisciplinary; neutrophil; nonhuman primate; novel; prevent; programs; recruit; research and development

ABSTRACT The objective of this proposal is to establish a Center of Excellence (COE) in Pulmonary Diseases that is highly interactive and consists of a dynamic group of junior investigators whose research focus is on understanding the molecular and cellular immunological mechanisms associated with the pathogenesis if lung diseases. The Promising Junior Investigators (PJIs) have proposed four independent but complementary research projects that will use molecular, immunological, and pathological approaches to investigate lung diseases in mouse and non-human primate models. They will also use de-identified human samples to validate their findings from preclinical models. We will determine the host signaling molecules, such as IDO, ITK, IL4Rand TTP in the initiation of protective host immune responses to infectious (bacterial/viral) and non-infectious agents (allergens). The long-term goal is to establish a collaborative, productive, sustainable, and nationally/internationally recognized COE in Pulmonary Disease research. The Specific Aims are: 1. To promote the establishment of a nationally/internationally recognized COE in Pulmonary Diseases. With the support of LSU, this COBRE-funded center will ensure that the pulmonary disease research group is sustainable and will provide much-needed resources to expand this research area which is primarily supported by the state of Louisiana; 2. To facilitate the improvement in research infrastructure for enhancing competitiveness for extramural grants. In addition to existing core facilities through NIGMS-funded COBRE-III, INBRE, and Louisiana Clinical and Translational Center (LA CaTS) in Baton Rouge, we will establish two scientific cores, such as Pulmonary Immunopathology and Molecular Biology. We will also renovate the office spaces into conventional animal holding and equipment rooms to have a dedicates suite for COBRE investigators. We will recruit 2 PJIs with complementary research areas in 2-3 years and 6 PJIs for the entire COBRE-I duration. The LSU School of Veterinary Medicine (SVM) has committed to purchase of new equipment, provide service contracts and the COBRE will offer salaries to scientific and technical staff; and 3. To develop an administrative infrastructure to promote the independent career of PJIs. We have assembled senior scientists with outstanding track record to serve on the Internal Scientific and advisory committee (ISAC), external advisory board (EAB), and mentoring committee (MC) that will carefully evaluate scientific needs of each PJI and tailor the mentoring plan based on the individual’s need. Two mentors: one local (Baton Rouge) and one outside LSU (Louisiana) have been assigned. The PJIs will attend career development workshops and will participate in ethics and scientific writing. We will nominate PJIs for the NIH/CSR Early Career Grant Reviewer program. We will also assist PJIs with their presentations to the ISAC, EAB, and MC to seek their feedback on their grants submissions. The team assembled here is exceptionally matched to the research goals, complementary expertise in lung immunology, multidisciplinary, and has a solid history of productive collaboration. This COBRE program will provide novel insights into the pathogenesis of devastating lung diseases that guide future improved strategies to treating and preventing these and other lung diseases in human population.

摘要

项目成果

Higher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells.

雄性对博来霉素诱导的肺部炎症的敏感性更高，与髓样细胞中性别特异性的转录组差异有关。

• DOI: 10.1016/j.taap.2022.116228
• 发表时间: 2022-11-01
• 期刊: Toxicology and applied pharmacology
• 影响因子: 3.8
• 作者: Lamichhane R;Patial S;Saini Y
• 通讯作者: Saini Y

In utero exposures to mint-flavored JUUL aerosol impair lung development and aggravate house dust mite-induced asthma in adult offspring mice.

• DOI: 10.1016/j.tox.2022.153272
• 发表时间: 2022-07
• 期刊: TOXICOLOGY
• 影响因子: 4.5
• 作者: Cahill, Kerin M.;Johnson, Trenton K.;Perveen, Zakia;Schexnayder, Matthew;Xiao, Rui;Heffernan, Linda M.;Langohr, Ingeborg M.;Paulsen, Daniel B.;Penn, Arthur L.;Noel, Alexandra
• 通讯作者: Noel, Alexandra

Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development.

• DOI: 10.1016/j.celrep.2023.112166
• 发表时间: 2023-03-28
• 期刊: Cell reports
• 影响因子: 8.8

The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice.

• DOI: 10.4049/jimmunol.2000530
• 发表时间: 2020-09-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Lewis BW;Choudhary I;Paudel K;Mao Y;Sharma R;Wang Y;Deshane JS;Boucher RC;Patial S;Saini Y
• 通讯作者: Saini Y

Ubiquitin Engineering for Interrogating the Ubiquitin-Proteasome System and Novel Therapeutic Strategies.

• DOI: 10.3390/cells12162117
• 发表时间: 2023-08-21
• 期刊: Cells
• 影响因子: 6