Center for Lung Biology and Disease
肺生物学与疾病中心
基本信息
- 批准号:10588205
- 负责人:
- 金额:$ 223.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-01-02 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAcute Lung InjuryAdvisory CommitteesAllergensAlveolar MacrophagesAnimalsAntigen-Antibody ComplexAreaAwardBasic ScienceBiologyBiomedical ResearchCellsCenters of Research ExcellenceClinicalCollaborationsContract ServicesCore FacilityDedicationsDevelopmentDisciplineDiseaseEconomic DevelopmentEducational workshopEnsureEnvironmentEquipmentEthicsExtramural ActivitiesExtrinsic asthmaFeedbackFosteringFundingFutureGoalsGrantHumanImmune responseImmunologicsImmunologyIndividualInfectious Diseases ResearchInfluenzaInfrastructureInstitutionInterdisciplinary StudyInternationalLifeLouisianaLungLung diseasesMentored Research Scientist Development AwardMentorsModelingMolecularMolecular BiologyMusNational Institute of General Medical SciencesPathogenesisPathologicPhasePopulationPre-Clinical ModelProcessProductivityPulmonary InflammationRecording of previous eventsRecordsRegulationResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResourcesRespiratory DiseaseSamplingSenior ScientistSignaling MoleculeSolidStimulusStrategic PlanningT-Lymphocyte SubsetsTuberculosisUnited States National Institutes of HealthUniversitiesVeterinary MedicineVeterinary SchoolsViralWagesWritingcareercareer developmentdesigneosinophilexperienceimmune functionimmunopathologyimprovedinnovationinsightinterestmultidisciplinaryneutrophilnonhuman primatenovelpreventprogramsrecruitresearch and development
项目摘要
ABSTRACT
The objective of this proposal is to establish a Center of Excellence (COE) in Pulmonary Diseases
that is highly interactive and consists of a dynamic group of junior investigators whose research focus
is on understanding the molecular and cellular immunological mechanisms associated with the
pathogenesis if lung diseases. The Promising Junior Investigators (PJIs) have proposed four
independent but complementary research projects that will use molecular, immunological, and
pathological approaches to investigate lung diseases in mouse and non-human primate models. They
will also use de-identified human samples to validate their findings from preclinical models. We will
determine the host signaling molecules, such as IDO, ITK, IL4Rand TTP in the initiation of
protective host immune responses to infectious (bacterial/viral) and non-infectious agents (allergens).
The long-term goal is to establish a collaborative, productive, sustainable, and
nationally/internationally recognized COE in Pulmonary Disease research. The Specific Aims are: 1.
To promote the establishment of a nationally/internationally recognized COE in Pulmonary Diseases.
With the support of LSU, this COBRE-funded center will ensure that the pulmonary disease research
group is sustainable and will provide much-needed resources to expand this research area which is
primarily supported by the state of Louisiana; 2. To facilitate the improvement in research
infrastructure for enhancing competitiveness for extramural grants. In addition to existing core
facilities through NIGMS-funded COBRE-III, INBRE, and Louisiana Clinical and Translational Center
(LA CaTS) in Baton Rouge, we will establish two scientific cores, such as Pulmonary
Immunopathology and Molecular Biology. We will also renovate the office spaces into conventional
animal holding and equipment rooms to have a dedicates suite for COBRE investigators. We will
recruit 2 PJIs with complementary research areas in 2-3 years and 6 PJIs for the entire COBRE-I
duration. The LSU School of Veterinary Medicine (SVM) has committed to purchase of new
equipment, provide service contracts and the COBRE will offer salaries to scientific and technical
staff; and 3. To develop an administrative infrastructure to promote the independent career of PJIs.
We have assembled senior scientists with outstanding track record to serve on the Internal Scientific
and advisory committee (ISAC), external advisory board (EAB), and mentoring committee (MC) that
will carefully evaluate scientific needs of each PJI and tailor the mentoring plan based on the
individual’s need. Two mentors: one local (Baton Rouge) and one outside LSU (Louisiana) have been
assigned. The PJIs will attend career development workshops and will participate in ethics and
scientific writing. We will nominate PJIs for the NIH/CSR Early Career Grant Reviewer program. We
will also assist PJIs with their presentations to the ISAC, EAB, and MC to seek their feedback on their
grants submissions. The team assembled here is exceptionally matched to the research goals,
complementary expertise in lung immunology, multidisciplinary, and has a solid history of productive
collaboration. This COBRE program will provide novel insights into the pathogenesis of devastating
lung diseases that guide future improved strategies to treating and preventing these and other lung
diseases in human population.
摘要
这项建议的目标是建立一个肺部疾病卓越中心(COE
这是高度互动的,由一群充满活力的初级调查人员组成,他们的研究重点是
是关于理解与之相关的分子和细胞免疫机制
如果肺部疾病的发病机制。有前途的初级调查人员(PJI)提出了四项建议
独立但互补的研究项目,将使用分子、免疫学和
研究小鼠和非人类灵长类动物肺部疾病的病理学方法。他们
还将使用未识别的人类样本来验证他们在临床前模型中的发现。我们会
确定Ido、Itk、IL4R、和Ttp等宿主信号分子在起病过程中的作用
对感染性(细菌/病毒)和非感染性物质(过敏原)的保护性宿主免疫反应。
我们的长期目标是建立协作、高效、可持续和
国家/国际公认的肺部疾病研究中的COE。具体目标是:1.
推动建立国家/国际公认的肺部疾病COE。
在路易斯安那州立大学的支持下,这个由科布雷资助的中心将确保肺部疾病的研究
集团是可持续的,并将提供急需的资源来扩大这一研究领域,这是
主要由路易斯安那州支持;2.促进研究的改进
加强校外赠款竞争力的基础设施。除了现有核心之外
通过NIGMS资助的COBRE-III、INBRE和路易斯安那州临床和翻译中心提供的设施
在巴吞鲁日,我们将建立两个科学核心,如肺
免疫病理学和分子生物学。我们还将把办公空间改造成传统的
动物保管室和设备室将为科布雷调查人员提供专门的套房。我们会
在2-3年内招聘2名具有互补研究领域的PJI,并为整个Cobre-I招聘6名PJI
持续时间。路易斯安那州立大学兽医学院已承诺购买新的
设备,提供服务合同,科布雷将为科学和技术人员提供工资
3.发展行政基础设施,以促进和平与正义运动的独立事业。
我们召集了有出色记录的资深科学家为内部科学委员会服务
和咨询委员会(ISAC)、外部顾问委员会(EAB)和指导委员会(MC)
将仔细评估每个PJI的科学需求,并根据
个人的需要。两位导师:一位是当地的(巴吞鲁日),一位是路易斯安那州立大学以外的(路易斯安那)
已分配。PJI将参加职业发展研讨会,并将参加道德和
科学写作。我们将为NIH/CSR早期职业资助评审计划提名PJI。我们
还将协助PJI向ISAC、EAB和MC进行演示,以征求他们对其
资助金申请。聚集在这里的团队与研究目标格外匹配,
在肺部免疫学方面的互补专业知识,多学科,并有坚实的生产历史
协作。这个Cobre计划将为毁灭性的
肺部疾病,指导未来改善治疗和预防这些和其他肺部疾病的策略
人类人口中的疾病。
项目成果
期刊论文数量(40)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Higher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells.
雄性对博来霉素诱导的肺部炎症的敏感性更高,与髓样细胞中性别特异性的转录组差异有关。
- DOI:10.1016/j.taap.2022.116228
- 发表时间:2022-11-01
- 期刊:
- 影响因子:3.8
- 作者:Lamichhane R;Patial S;Saini Y
- 通讯作者:Saini Y
In utero exposures to mint-flavored JUUL aerosol impair lung development and aggravate house dust mite-induced asthma in adult offspring mice.
- DOI:10.1016/j.tox.2022.153272
- 发表时间:2022-07
- 期刊:
- 影响因子:4.5
- 作者:Cahill, Kerin M.;Johnson, Trenton K.;Perveen, Zakia;Schexnayder, Matthew;Xiao, Rui;Heffernan, Linda M.;Langohr, Ingeborg M.;Paulsen, Daniel B.;Penn, Arthur L.;Noel, Alexandra
- 通讯作者:Noel, Alexandra
Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development.
- DOI:10.1016/j.celrep.2023.112166
- 发表时间:2023-03-28
- 期刊:
- 影响因子:8.8
- 作者:
- 通讯作者:
The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice.
- DOI:10.4049/jimmunol.2000530
- 发表时间:2020-09-15
- 期刊:
- 影响因子:0
- 作者:Lewis BW;Choudhary I;Paudel K;Mao Y;Sharma R;Wang Y;Deshane JS;Boucher RC;Patial S;Saini Y
- 通讯作者:Saini Y
Role of toll-like receptors and nod-like receptors in acute lung infection.
- DOI:10.3389/fimmu.2023.1249098
- 发表时间:2023
- 期刊:
- 影响因子:7.3
- 作者:Le, John;Kulatheepan, Yathushigan;Jeyaseelan, Samithamby
- 通讯作者:Jeyaseelan, Samithamby
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
TAMMY R DUGAS其他文献
TAMMY R DUGAS的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('TAMMY R DUGAS', 18)}}的其他基金
Novel coatings releasing synergistic polyphenols promote vascular healing
新型涂层释放协同多酚促进血管愈合
- 批准号:
8716232 - 财政年份:2014
- 资助金额:
$ 223.6万 - 项目类别:
Novel coatings releasing synergistic polyphenols promote vascular healing
新型涂层释放协同多酚促进血管愈合
- 批准号:
8918078 - 财政年份:2014
- 资助金额:
$ 223.6万 - 项目类别:
Research Experience and Training Coordination Core (RETCC)
研究经验和培训协调核心(RETCC)
- 批准号:
10341189 - 财政年份:2009
- 资助金额:
$ 223.6万 - 项目类别:
Combustion-Generated EPFRs: Assessing Cardiovascular Risks of Exposure
燃烧产生的 EPFR:评估暴露的心血管风险
- 批准号:
10576461 - 财政年份:2009
- 资助金额:
$ 223.6万 - 项目类别:
Combustion-Generated EPFRs: Assessing Cardiovascular Risks of Exposure
燃烧产生的 EPFR:评估暴露的心血管风险
- 批准号:
10341193 - 财政年份:2009
- 资助金额:
$ 223.6万 - 项目类别:
Antiretroviral Therapy, Endothelial Dysfunction and Atherosclerosis
抗逆转录病毒治疗、内皮功能障碍和动脉粥样硬化
- 批准号:
7838921 - 财政年份:2009
- 资助金额:
$ 223.6万 - 项目类别:
Research Experience and Training Coordination Core (RETCC)
研究经验和培训协调核心(RETCC)
- 批准号:
10576457 - 财政年份:2009
- 资助金额:
$ 223.6万 - 项目类别:
Combustion-Generated EPFRs: Assessing Cardiovascular Risks of Exposure
燃烧产生的 EPFR:评估暴露的心血管风险
- 批准号:
10116407 - 财政年份:2009
- 资助金额:
$ 223.6万 - 项目类别:
相似海外基金
Combinatorial cytokine-coated macrophages for targeted immunomodulation in acute lung injury
组合细胞因子包被的巨噬细胞用于急性肺损伤的靶向免疫调节
- 批准号:
10648387 - 财政年份:2023
- 资助金额:
$ 223.6万 - 项目类别:
Lung epithelial cell-derived C3 in acute lung injury
肺上皮细胞衍生的 C3 在急性肺损伤中的作用
- 批准号:
10720687 - 财政年份:2023
- 资助金额:
$ 223.6万 - 项目类别:
Examining the role of TRMT1 and tRNA methylation in acute lung injury and ARDS
检查 TRMT1 和 tRNA 甲基化在急性肺损伤和 ARDS 中的作用
- 批准号:
10719249 - 财政年份:2023
- 资助金额:
$ 223.6万 - 项目类别:
Inducible HMGB1 antagonist for viral-induced acute lung injury.
诱导型 HMGB1 拮抗剂,用于治疗病毒引起的急性肺损伤。
- 批准号:
10591804 - 财政年份:2023
- 资助金额:
$ 223.6万 - 项目类别:
MAP2K1 AND MAP2K2 IN ACUTE LUNG INJURY AND RESOLUTION
MAP2K1 和 MAP2K2 在急性肺损伤中的作用及缓解
- 批准号:
10741574 - 财政年份:2023
- 资助金额:
$ 223.6万 - 项目类别:
Development of a new treatment for COVID-19-related acute lung injury targeting the microbiota-derived peptide corisin
针对微生物群衍生肽 corisin 开发治疗 COVID-19 相关急性肺损伤的新疗法
- 批准号:
23K07651 - 财政年份:2023
- 资助金额:
$ 223.6万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Probing immunovascular mechanobiology in pneumonia-associated acute lung injury at the single capillary level
在单毛细血管水平探讨肺炎相关急性肺损伤的免疫血管力学生物学
- 批准号:
10679944 - 财政年份:2023
- 资助金额:
$ 223.6万 - 项目类别:
The amyloid precursor protein protects against acute lung injury
淀粉样前体蛋白可预防急性肺损伤
- 批准号:
10575258 - 财政年份:2023
- 资助金额:
$ 223.6万 - 项目类别:
Role of macrophages and miRNA in regulating lung macrophage polarization and lung pathogenesis during respiratory virus-induced acute lung injury in normal and diabetic Syrian hamsters.
正常和糖尿病叙利亚仓鼠呼吸道病毒引起的急性肺损伤期间巨噬细胞和 miRNA 在调节肺巨噬细胞极化和肺部发病机制中的作用。
- 批准号:
10701207 - 财政年份:2023
- 资助金额:
$ 223.6万 - 项目类别:
Roles of N-glycans on neutrophil beta2 integrins in progression of acute lung injury
N-聚糖对中性粒细胞β2整合素在急性肺损伤进展中的作用
- 批准号:
10837431 - 财政年份:2023
- 资助金额:
$ 223.6万 - 项目类别:














{{item.name}}会员




