Center for Lung Biology and Disease

肺生物学与疾病中心

• 批准号: 10588205
• 负责人: TAMMY R DUGAS
• 金额: $ 223.6万
• 依托单位: LOUISIANA STATE UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-02 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10588205
• 关键词: Acceleration; Acute Lung Injury; Advisory Committees; Allergens; Alveolar Macrophages; Animals; Antigen-Antibody Complex; Area; Award; Basic Science; Biology; Biomedical Research; Cells; Centers of Research Excellence; Clinical; Collaborations; Contract Services; Core Facility; Dedications; Development; Discipline; Disease; Economic Development; Educational workshop; Ensure; Environment; Equipment; Ethics; Extramural Activities; Extrinsic asthma; Feedback; Fostering; Funding; Future; Goals; Grant; Human; Immune response; Immunologics; Immunology; Individual; Infectious Diseases Research; Influenza; Infrastructure; Institution; Interdisciplinary Study; International; Life; Louisiana; Lung; Lung diseases; Mentored Research Scientist Development Award; Mentors; Modeling; Molecular; Molecular Biology; Mus; National Institute of General Medical Sciences; Pathogenesis; Pathologic; Phase; Population; Pre-Clinical Model; Process; Productivity; Pulmonary Inflammation; Recording of previous events; Records; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Respiratory Disease; Sampling; Senior Scientist; Signaling Molecule; Solid; Stimulus; Strategic Planning; T-Lymphocyte Subsets; Tuberculosis; United States National Institutes of Health; Universities; Veterinary Medicine; Veterinary Schools; Viral; Wages; Writing; career; career development; design; eosinophil; experience; immune function; immunopathology; improved; innovation; insight; interest; multidisciplinary; neutrophil; nonhuman primate; novel; prevent; programs; recruit; research and development

ABSTRACT The objective of this proposal is to establish a Center of Excellence (COE) in Pulmonary Diseases that is highly interactive and consists of a dynamic group of junior investigators whose research focus is on understanding the molecular and cellular immunological mechanisms associated with the pathogenesis if lung diseases. The Promising Junior Investigators (PJIs) have proposed four independent but complementary research projects that will use molecular, immunological, and pathological approaches to investigate lung diseases in mouse and non-human primate models. They will also use de-identified human samples to validate their findings from preclinical models. We will determine the host signaling molecules, such as IDO, ITK, IL4Rand TTP in the initiation of protective host immune responses to infectious (bacterial/viral) and non-infectious agents (allergens). The long-term goal is to establish a collaborative, productive, sustainable, and nationally/internationally recognized COE in Pulmonary Disease research. The Specific Aims are: 1. To promote the establishment of a nationally/internationally recognized COE in Pulmonary Diseases. With the support of LSU, this COBRE-funded center will ensure that the pulmonary disease research group is sustainable and will provide much-needed resources to expand this research area which is primarily supported by the state of Louisiana; 2. To facilitate the improvement in research infrastructure for enhancing competitiveness for extramural grants. In addition to existing core facilities through NIGMS-funded COBRE-III, INBRE, and Louisiana Clinical and Translational Center (LA CaTS) in Baton Rouge, we will establish two scientific cores, such as Pulmonary Immunopathology and Molecular Biology. We will also renovate the office spaces into conventional animal holding and equipment rooms to have a dedicates suite for COBRE investigators. We will recruit 2 PJIs with complementary research areas in 2-3 years and 6 PJIs for the entire COBRE-I duration. The LSU School of Veterinary Medicine (SVM) has committed to purchase of new equipment, provide service contracts and the COBRE will offer salaries to scientific and technical staff; and 3. To develop an administrative infrastructure to promote the independent career of PJIs. We have assembled senior scientists with outstanding track record to serve on the Internal Scientific and advisory committee (ISAC), external advisory board (EAB), and mentoring committee (MC) that will carefully evaluate scientific needs of each PJI and tailor the mentoring plan based on the individual’s need. Two mentors: one local (Baton Rouge) and one outside LSU (Louisiana) have been assigned. The PJIs will attend career development workshops and will participate in ethics and scientific writing. We will nominate PJIs for the NIH/CSR Early Career Grant Reviewer program. We will also assist PJIs with their presentations to the ISAC, EAB, and MC to seek their feedback on their grants submissions. The team assembled here is exceptionally matched to the research goals, complementary expertise in lung immunology, multidisciplinary, and has a solid history of productive collaboration. This COBRE program will provide novel insights into the pathogenesis of devastating lung diseases that guide future improved strategies to treating and preventing these and other lung diseases in human population.

摘要 这项建议的目标是建立一个肺部疾病卓越中心(COE 这是高度互动的，由一群充满活力的初级调查人员组成，他们的研究重点是 是关于理解与之相关的分子和细胞免疫机制 如果肺部疾病的发病机制。有前途的初级调查人员(PJI)提出了四项建议 独立但互补的研究项目，将使用分子、免疫学和 研究小鼠和非人类灵长类动物肺部疾病的病理学方法。他们 还将使用未识别的人类样本来验证他们在临床前模型中的发现。我们会 确定Ido、Itk、IL4R、和Ttp等宿主信号分子在起病过程中的作用 对感染性(细菌/病毒)和非感染性物质(过敏原)的保护性宿主免疫反应。 我们的长期目标是建立协作、高效、可持续和 国家/国际公认的肺部疾病研究中的COE。具体目标是：1. 推动建立国家/国际公认的肺部疾病COE。 在路易斯安那州立大学的支持下，这个由科布雷资助的中心将确保肺部疾病的研究 集团是可持续的，并将提供急需的资源来扩大这一研究领域，这是 主要由路易斯安那州支持；2.促进研究的改进 加强校外赠款竞争力的基础设施。除了现有核心之外 通过NIGMS资助的COBRE-III、INBRE和路易斯安那州临床和翻译中心提供的设施 在巴吞鲁日，我们将建立两个科学核心，如肺 免疫病理学和分子生物学。我们还将把办公空间改造成传统的 动物保管室和设备室将为科布雷调查人员提供专门的套房。我们会 在2-3年内招聘2名具有互补研究领域的PJI，并为整个Cobre-I招聘6名PJI 持续时间。路易斯安那州立大学兽医学院已承诺购买新的 设备，提供服务合同，科布雷将为科学和技术人员提供工资 3.发展行政基础设施，以促进和平与正义运动的独立事业。 我们召集了有出色记录的资深科学家为内部科学委员会服务 和咨询委员会(ISAC)、外部顾问委员会(EAB)和指导委员会(MC) 将仔细评估每个PJI的科学需求，并根据 个人的需要。两位导师：一位是当地的(巴吞鲁日)，一位是路易斯安那州立大学以外的(路易斯安那) 已分配。PJI将参加职业发展研讨会，并将参加道德和 科学写作。我们将为NIH/CSR早期职业资助评审计划提名PJI。我们 还将协助PJI向ISAC、EAB和MC进行演示，以征求他们对其 资助金申请。聚集在这里的团队与研究目标格外匹配， 在肺部免疫学方面的互补专业知识，多学科，并有坚实的生产历史 协作。这个Cobre计划将为毁灭性的 肺部疾病，指导未来改善治疗和预防这些和其他肺部疾病的策略 人类人口中的疾病。

项目成果

Higher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells.

雄性对博来霉素诱导的肺部炎症的敏感性更高，与髓样细胞中性别特异性的转录组差异有关。

• DOI: 10.1016/j.taap.2022.116228
• 发表时间: 2022-11-01
• 期刊: Toxicology and applied pharmacology
• 影响因子: 3.8
• 作者: Lamichhane R;Patial S;Saini Y
• 通讯作者: Saini Y

In utero exposures to mint-flavored JUUL aerosol impair lung development and aggravate house dust mite-induced asthma in adult offspring mice.

• DOI: 10.1016/j.tox.2022.153272
• 发表时间: 2022-07
• 期刊: TOXICOLOGY
• 影响因子: 4.5
• 作者: Cahill, Kerin M.;Johnson, Trenton K.;Perveen, Zakia;Schexnayder, Matthew;Xiao, Rui;Heffernan, Linda M.;Langohr, Ingeborg M.;Paulsen, Daniel B.;Penn, Arthur L.;Noel, Alexandra
• 通讯作者: Noel, Alexandra

Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development.

• DOI: 10.1016/j.celrep.2023.112166
• 发表时间: 2023-03-28
• 期刊: Cell reports
• 影响因子: 8.8

The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice.

• DOI: 10.4049/jimmunol.2000530
• 发表时间: 2020-09-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Lewis BW;Choudhary I;Paudel K;Mao Y;Sharma R;Wang Y;Deshane JS;Boucher RC;Patial S;Saini Y
• 通讯作者: Saini Y

Role of toll-like receptors and nod-like receptors in acute lung infection.

• DOI: 10.3389/fimmu.2023.1249098
• 发表时间: 2023
• 期刊: FRONTIERS IN IMMUNOLOGY
• 影响因子: 7.3
• 作者: Le, John;Kulatheepan, Yathushigan;Jeyaseelan, Samithamby
• 通讯作者: Jeyaseelan, Samithamby