Center for Lung Biology and Disease
肺生物学与疾病中心
基本信息
- 批准号:10588205
- 负责人:
- 金额:$ 223.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-01-02 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAcute Lung InjuryAdvisory CommitteesAllergensAlveolar MacrophagesAnimalsAntigen-Antibody ComplexAreaAwardBasic ScienceBiologyBiomedical ResearchCellsCenters of Research ExcellenceClinicalCollaborationsContract ServicesCore FacilityDedicationsDevelopmentDisciplineDiseaseEconomic DevelopmentEducational workshopEnsureEnvironmentEquipmentEthicsExtramural ActivitiesExtrinsic asthmaFeedbackFosteringFundingFutureGoalsGrantHumanImmune responseImmunologicsImmunologyIndividualInfectious Diseases ResearchInfluenzaInfrastructureInstitutionInterdisciplinary StudyInternationalLifeLouisianaLungLung diseasesMentored Research Scientist Development AwardMentorsModelingMolecularMolecular BiologyMusNational Institute of General Medical SciencesPathogenesisPathologicPhasePopulationPre-Clinical ModelProcessProductivityPulmonary InflammationRecording of previous eventsRecordsRegulationResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResourcesRespiratory DiseaseSamplingSenior ScientistSignaling MoleculeSolidStimulusStrategic PlanningT-Lymphocyte SubsetsTuberculosisUnited States National Institutes of HealthUniversitiesVeterinary MedicineVeterinary SchoolsViralWagesWritingcareercareer developmentdesigneosinophilexperienceimmune functionimmunopathologyimprovedinnovationinsightinterestmultidisciplinaryneutrophilnonhuman primatenovelpreventprogramsrecruitresearch and development
项目摘要
ABSTRACT
The objective of this proposal is to establish a Center of Excellence (COE) in Pulmonary Diseases
that is highly interactive and consists of a dynamic group of junior investigators whose research focus
is on understanding the molecular and cellular immunological mechanisms associated with the
pathogenesis if lung diseases. The Promising Junior Investigators (PJIs) have proposed four
independent but complementary research projects that will use molecular, immunological, and
pathological approaches to investigate lung diseases in mouse and non-human primate models. They
will also use de-identified human samples to validate their findings from preclinical models. We will
determine the host signaling molecules, such as IDO, ITK, IL4Rand TTP in the initiation of
protective host immune responses to infectious (bacterial/viral) and non-infectious agents (allergens).
The long-term goal is to establish a collaborative, productive, sustainable, and
nationally/internationally recognized COE in Pulmonary Disease research. The Specific Aims are: 1.
To promote the establishment of a nationally/internationally recognized COE in Pulmonary Diseases.
With the support of LSU, this COBRE-funded center will ensure that the pulmonary disease research
group is sustainable and will provide much-needed resources to expand this research area which is
primarily supported by the state of Louisiana; 2. To facilitate the improvement in research
infrastructure for enhancing competitiveness for extramural grants. In addition to existing core
facilities through NIGMS-funded COBRE-III, INBRE, and Louisiana Clinical and Translational Center
(LA CaTS) in Baton Rouge, we will establish two scientific cores, such as Pulmonary
Immunopathology and Molecular Biology. We will also renovate the office spaces into conventional
animal holding and equipment rooms to have a dedicates suite for COBRE investigators. We will
recruit 2 PJIs with complementary research areas in 2-3 years and 6 PJIs for the entire COBRE-I
duration. The LSU School of Veterinary Medicine (SVM) has committed to purchase of new
equipment, provide service contracts and the COBRE will offer salaries to scientific and technical
staff; and 3. To develop an administrative infrastructure to promote the independent career of PJIs.
We have assembled senior scientists with outstanding track record to serve on the Internal Scientific
and advisory committee (ISAC), external advisory board (EAB), and mentoring committee (MC) that
will carefully evaluate scientific needs of each PJI and tailor the mentoring plan based on the
individual’s need. Two mentors: one local (Baton Rouge) and one outside LSU (Louisiana) have been
assigned. The PJIs will attend career development workshops and will participate in ethics and
scientific writing. We will nominate PJIs for the NIH/CSR Early Career Grant Reviewer program. We
will also assist PJIs with their presentations to the ISAC, EAB, and MC to seek their feedback on their
grants submissions. The team assembled here is exceptionally matched to the research goals,
complementary expertise in lung immunology, multidisciplinary, and has a solid history of productive
collaboration. This COBRE program will provide novel insights into the pathogenesis of devastating
lung diseases that guide future improved strategies to treating and preventing these and other lung
diseases in human population.
摘要
项目成果
期刊论文数量(40)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Higher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells.
雄性对博来霉素诱导的肺部炎症的敏感性更高,与髓样细胞中性别特异性的转录组差异有关。
- DOI:10.1016/j.taap.2022.116228
- 发表时间:2022-11-01
- 期刊:
- 影响因子:3.8
- 作者:Lamichhane R;Patial S;Saini Y
- 通讯作者:Saini Y
In utero exposures to mint-flavored JUUL aerosol impair lung development and aggravate house dust mite-induced asthma in adult offspring mice.
- DOI:10.1016/j.tox.2022.153272
- 发表时间:2022-07
- 期刊:
- 影响因子:4.5
- 作者:Cahill, Kerin M.;Johnson, Trenton K.;Perveen, Zakia;Schexnayder, Matthew;Xiao, Rui;Heffernan, Linda M.;Langohr, Ingeborg M.;Paulsen, Daniel B.;Penn, Arthur L.;Noel, Alexandra
- 通讯作者:Noel, Alexandra
Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development.
- DOI:10.1016/j.celrep.2023.112166
- 发表时间:2023-03-28
- 期刊:
- 影响因子:8.8
- 作者:
- 通讯作者:
The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice.
- DOI:10.4049/jimmunol.2000530
- 发表时间:2020-09-15
- 期刊:
- 影响因子:0
- 作者:Lewis BW;Choudhary I;Paudel K;Mao Y;Sharma R;Wang Y;Deshane JS;Boucher RC;Patial S;Saini Y
- 通讯作者:Saini Y
Ubiquitin Engineering for Interrogating the Ubiquitin-Proteasome System and Novel Therapeutic Strategies.
- DOI:10.3390/cells12162117
- 发表时间:2023-08-21
- 期刊:
- 影响因子:6
- 作者:
- 通讯作者:
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{{ truncateString('TAMMY R DUGAS', 18)}}的其他基金
Novel coatings releasing synergistic polyphenols promote vascular healing
新型涂层释放协同多酚促进血管愈合
- 批准号:
8918078 - 财政年份:2014
- 资助金额:
$ 223.6万 - 项目类别:
Novel coatings releasing synergistic polyphenols promote vascular healing
新型涂层释放协同多酚促进血管愈合
- 批准号:
8716232 - 财政年份:2014
- 资助金额:
$ 223.6万 - 项目类别:
Research Experience and Training Coordination Core (RETCC)
研究经验和培训协调核心(RETCC)
- 批准号:
10341189 - 财政年份:2009
- 资助金额:
$ 223.6万 - 项目类别:
Combustion-Generated EPFRs: Assessing Cardiovascular Risks of Exposure
燃烧产生的 EPFR:评估暴露的心血管风险
- 批准号:
10576461 - 财政年份:2009
- 资助金额:
$ 223.6万 - 项目类别:
Combustion-Generated EPFRs: Assessing Cardiovascular Risks of Exposure
燃烧产生的 EPFR:评估暴露的心血管风险
- 批准号:
10341193 - 财政年份:2009
- 资助金额:
$ 223.6万 - 项目类别:
Antiretroviral Therapy, Endothelial Dysfunction and Atherosclerosis
抗逆转录病毒治疗、内皮功能障碍和动脉粥样硬化
- 批准号:
7838921 - 财政年份:2009
- 资助金额:
$ 223.6万 - 项目类别:
Research Experience and Training Coordination Core (RETCC)
研究经验和培训协调核心(RETCC)
- 批准号:
10576457 - 财政年份:2009
- 资助金额:
$ 223.6万 - 项目类别:
Combustion-Generated EPFRs: Assessing Cardiovascular Risks of Exposure
燃烧产生的 EPFR:评估暴露的心血管风险
- 批准号:
10116407 - 财政年份:2009
- 资助金额:
$ 223.6万 - 项目类别:
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