Neurocognitive Mechanisms Underlying Smartphone-Assisted Prevention of Relapse in Opioid Use Disorder
智能手机辅助预防阿片类药物使用障碍复发的神经认知机制
基本信息
- 批准号:10459236
- 负责人:
- 金额:$ 54.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AbstinenceAdjuvant AnalgesicAlcohol consumptionAreaArkansasAttenuatedBehaviorBody Weight decreasedBrainBuprenorphineCellular PhoneCessation of lifeClinical TrialsCognitionCoupledCuesDataDependenceDrug MonitoringDrug usageEcological momentary assessmentEnergy IntakeEnrollmentFeedbackFibrinogenFunctional Magnetic Resonance ImagingGeographyGoalsHealthHealthcareHomelessnessHot SpotHotlinesIndividualIndividual DifferencesInpatientsInterventionLocationMental DepressionMethadoneModelingMonitorNaltrexoneNeurocognitiveNotificationOpioidOpioid RotationOutcomeOutpatientsOverdoseParticipantPatientsPatternPharmaceutical PreparationsPublic HealthRandomizedRandomized Controlled TrialsRelapseReportingResourcesRiskRoleRuralSelf AssessmentServicesShapesSubstance Use DisorderTechnologyTelemedicineTestingTimeTreatment outcomeUnited StatesUnsafe SexUrinalysisWithdrawal SymptomWorkalcohol misusearmattentional biasbasebrain behaviorbrief motivational interventioncigarette smokingcravingdisorder later incidence preventiondrug cravingefficacious treatmentefficacy evaluationgeographic barrierhealth care availabilityhigh riskillicit opioidimprovedinnovationinsightmedication-assisted treatmentmeetingsmobile applicationmobile computingmortalityneural networkneuroimagingnovelopioid epidemicopioid misuseopioid overdoseopioid useopioid use disorderpersonalized interventionprescription opioidpreventrecruitreduced substance userelapse patientsrelapse riskrelating to nervous systemresponserural areasmartphone Applicationsmoking cessationtooltreatment responseurban areayoung adult
项目摘要
ABSTRACT
The rising public health burden of opioid misuse, coupled with high relapse rates among individuals seeking
treatment for opioid use disorder, necessitates novel interventions for improving opioid-related treatment
response. Mobile technology such as smartphone-based applications (“apps”) represent one such intervention.
Although smartphone apps are effective in reducing cigarette and alcohol use, their efficacy for reducing opioid
use has not yet been established. The proposed clinical trial would evaluate the app OPTiMA (“OPiate
Treatment Mobile App”) to prevent relapse among patients receiving medication-assisted treatment for opioid
use disorder. OPTiMA implements two features shown to be effective for reducing substance use: daily self-
monitoring of opiate use coupled with personalized feedback. Aim 1 would accrue 204 participants with 1:1
randomization into two arms (OPTiMA vs. Monitoring only) to evaluate differences in monthly opioid use at six
months post-enrollment. Aim 2 would enroll a subset of participants (N=120) into a longitudinal functional
neuroimaging (fMRI) study to model the neurocognitive mechanisms underlying individual differences in
treatment response. Two putative mechanisms (attentional bias for drug cues and cue-induced craving)
promoting abstinence would be studied. Aim 3 would explore the use of location-based geographic ecological
momentary assessment (GEMA) for targeted intervention when participants enter self-identified areas of high
risk for relapse. Collectively, the proposed aims would (1) evaluate mobile technology applications for reducing
opiate use, (2) understand the neurocognitive mechanisms of action to improve upon this and other apps
aiming to reduce drug use, and (3) evaluate the role of personalized, contextually-relevant intervention to
promote successful treatment outcomes.
摘要
阿片类药物滥用造成的公共卫生负担日益加重,加上寻求治疗的个人复发率很高,
阿片类药物使用障碍的治疗,需要新的干预措施来改善阿片类药物相关的治疗
反应移动的技术,如基于智能手机的应用程序(“应用程序”)代表了一种这样的干预。
虽然智能手机应用程序在减少吸烟和饮酒方面有效,但它们在减少阿片类药物使用方面的功效
用途尚未确定。拟议的临床试验将评估应用程序OPTIMA(“OPiate
治疗移动的应用程序”),以防止接受阿片类药物辅助治疗的患者复发
使用障碍。OPTIMA实现了两个功能,可有效减少物质用途:日常自我-
监测鸦片剂的使用情况,加上个性化的反馈。目标1将以1:1的比例增加204名参与者
随机分为两组(OPTIMA与仅监测),以评估6岁时每月阿片类药物使用的差异
入组后数月。目标2将入组一组受试者(N=120),
神经成像(fMRI)研究,以模拟神经认知机制的个体差异,
治疗反应。两种假定的机制(药物线索的注意偏向和线索诱导的渴望)
将研究促进节欲的问题。目标3将探索使用基于位置的地理生态
当参与者进入自我识别的高风险区域时,进行有针对性的干预的瞬时评估(GEMA)
复发的风险。总体而言,拟议的目标将(1)评估移动的技术应用,以减少
阿片类药物的使用,(2)了解神经认知机制的行动,以改善这一点和其他应用程序
目的是减少药物使用,(3)评估个性化的,背景相关的干预措施的作用,
促进成功的治疗结果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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George Andrew James其他文献
A full-size MRI-compatible keyboard response system
- DOI:
10.1016/j.neuroimage.2004.11.016 - 发表时间:
2005-03-01 - 期刊:
- 影响因子:
- 作者:
George Andrew James;Guojun He;Yijun Liu - 通讯作者:
Yijun Liu
George Andrew James的其他文献
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{{ truncateString('George Andrew James', 18)}}的其他基金
Neurocognitive Mechanisms Underlying Smartphone-Assisted Prevention of Relapse in Opioid Use Disorder
智能手机辅助预防阿片类药物使用障碍复发的神经认知机制
- 批准号:
10621945 - 财政年份:2021
- 资助金额:
$ 54.48万 - 项目类别:
The Sex-specific Roles and Neural Processing Correlates of Future Outcome Estimation in the Drug Addiction Process
吸毒过程中未来结果估计的性别特定角色和神经处理相关性
- 批准号:
10398821 - 财政年份:2018
- 资助金额:
$ 54.48万 - 项目类别:
Modeling sex-differences in trauma-related neural organization conferring resilience against addiction
模拟创伤相关神经组织中的性别差异,赋予其抗成瘾的能力
- 批准号:
9317079 - 财政年份:2017
- 资助金额:
$ 54.48万 - 项目类别: