权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Neurocognitive Mechanisms Underlying Smartphone-Assisted Prevention of Relapse in Opioid Use Disorder

智能手机辅助预防阿片类药物使用障碍复发的神经认知机制

基本信息

批准号：
10621945
负责人：
George Andrew James
金额：
$ 51.86万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10621945
关键词：
2 arm randomized control trial Abstinence Adjuvant Analgesic Alcohol consumption Area Arkansas Attenuated Behavior Body Weight decreased Brain Buprenorphine Cellular Phone Cessation of life Clinical Trials Cognition Coupled Cues Data Dependence Drug Monitoring Drug usage Ecological momentary assessment Energy Intake Enrollment Feedback Functional Magnetic Resonance Imaging Geography Goals Health Healthcare Homelessness Hot Spot Hotlines Individual Individual Differences Inpatients Intervention Location Maps Mental Depression Methadone Modeling Monitor Naltrexone Neurocognitive Notification Opioid Opioid Rotation Outcome Outpatients Overdose Participant Patients Pattern Pharmaceutical Preparations Public Health Randomized Randomized, Controlled Trials Relapse Reporting Resources Risk Role Rural Self Assessment Services Shapes Substance Use Disorder Technology Telemedicine Testing Time Treatment outcome United States Unsafe Sex Urinalysis Withdrawal Symptom Work alcohol misuse arm attentional bias brain behavior brief motivational intervention cigarette smoking craving drug craving efficacious treatment efficacy evaluation geographic barrier health care availability high risk illicit opioid improved innovation insight medication-assisted treatment meetings mobile application mobile computing mortality neural neural network neuroimaging novel opioid epidemic opioid misuse opioid overdose opioid use opioid use disorder personalized intervention prescription opioid recruit reduced alcohol use reduced substance use relapse patients relapse prevention relapse risk response rural area smartphone application smoking cessation tool treatment response urban area young adult

项目摘要

ABSTRACT The rising public health burden of opioid misuse, coupled with high relapse rates among individuals seeking treatment for opioid use disorder, necessitates novel interventions for improving opioid-related treatment response. Mobile technology such as smartphone-based applications (“apps”) represent one such intervention. Although smartphone apps are effective in reducing cigarette and alcohol use, their efficacy for reducing opioid use has not yet been established. The proposed clinical trial would evaluate the app OPTiMA (“OPiate Treatment Mobile App”) to prevent relapse among patients receiving medication-assisted treatment for opioid use disorder. OPTiMA implements two features shown to be effective for reducing substance use: daily self- monitoring of opiate use coupled with personalized feedback. Aim 1 would accrue 204 participants with 1:1 randomization into two arms (OPTiMA vs. Monitoring only) to evaluate differences in monthly opioid use at six months post-enrollment. Aim 2 would enroll a subset of participants (N=120) into a longitudinal functional neuroimaging (fMRI) study to model the neurocognitive mechanisms underlying individual differences in treatment response. Two putative mechanisms (attentional bias for drug cues and cue-induced craving) promoting abstinence would be studied. Aim 3 would explore the use of location-based geographic ecological momentary assessment (GEMA) for targeted intervention when participants enter self-identified areas of high risk for relapse. Collectively, the proposed aims would (1) evaluate mobile technology applications for reducing opiate use, (2) understand the neurocognitive mechanisms of action to improve upon this and other apps aiming to reduce drug use, and (3) evaluate the role of personalized, contextually-relevant intervention to promote successful treatment outcomes.

摘要