Single-cell computation in auditory brainstem and its impact on cortical coding and behavior

听觉脑干中的单细胞计算及其对皮质编码和行为的影响

基本信息

  • 批准号:
    10455326
  • 负责人:
  • 金额:
    $ 10.06万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-30 至 2023-05-31
  • 项目状态:
    已结题

项目摘要

Project Abstract Understanding how neuronal computations build up a perception of the external world is fundamental to our understanding of how the brain works. This is particularly relevant to sensory systems, where heterogenous inputs representing distinct sensory features must be re-assembled to generate a perception. How individual neurons in early stages of sensory circuits process parallel inputs, and how these circuit elements later contribute to cortical computations that bind the inputs together is completely unknown. Studies have demonstrated that the timing, position and strength of a given input along the dendrite of a given neuron is a critical strategy used by the brain to encode sensory features. However, how such dendritic integrations of inputs in single neurons contribute to an animal's overall perception is not understood. To re-assemble diverse features from the same initial stimulus, the brain needs to determine which features occurred at the same time. Currently, little is known about how or where this timing information might be encoded. The auditory system offers an ideal system to tackle this question based on its tractability to interdisciplinary methods and its known ability to encode even miniscule differences in timing. Specifically, we will take advantage of a unique cell type in the auditory cochlear nucleus, called octopus cells, as a model to investigate the question of how small cell classes contribute to behavioral and perceptual circuits. Octopus cells are prominent in all mammalian species and are well known to encode temporal inputs with submillisecond precision through integration of primary sensory inputs along their large and extensive dendrites. We propose to carry out a multi- lab, integrated analysis of the molecular and biophysical properties of octopus cells and to track how these single cell computations are transformed along the auditory pathway to contribute to an animal's final auditory percept and hence behavior. Using the mouse as a model system, we will apply new sequencing methods together with high resolution brain imaging and single cell reconstructions to create a comprehensive wiring diagram of octopus cells and their auditory inputs. By generating mouse strains for selective access to octopus cells, we will be ideally positioned to investigate the in vitro and in vivo physiology of octopus cells and therefore bridge experimental and computational models for how timing information is encoded at the single cell level. Lastly, we will study how timing information propagates to higher auditory centers by recording from large populations of neurons in the midbrain, thalamus, and cortex and then assessing the functional relevance of temporal coding for auditory behavior. By leveraging molecular, biophysical, electrophysiological, behavioral, and computational approaches toward the study of this model cell type, these studies will allow us to extract general principles of single cell computations and their effects on systems-level circuit function, with broad implications for understanding how parallel streams of information are integrated to generate sensory perception.
项目摘要 理解神经元计算如何建立对外部世界的感知是我们研究的基础。 了解大脑是如何工作的这与感觉系统特别相关,在感觉系统中, 代表不同感觉特征的输入必须被重新组合以产生感知。如何个性化 感觉回路早期阶段的神经元处理并行输入,以及这些回路元件后来如何贡献 大脑皮层的计算是完全未知的。研究已经证明 给定输入沿着给定神经元的树突的定时、位置和强度是所使用的关键策略 来编码感官特征。然而,如何在单个神经元中的输入的这种树突整合, 对动物整体感知的贡献还不清楚。 为了从相同的初始刺激中重新组合不同的特征,大脑需要确定哪些特征 发生在同一时间目前,很少有人知道如何或在哪里可以编码这种定时信息。 听觉系统以其跨学科的易处理性为解决这一问题提供了一个理想的系统 方法及其已知的编码能力,即使是微小的时间差异。具体来说,我们将利用 一种独特的细胞类型在听觉耳蜗核,称为章鱼细胞,作为研究这个问题的模型, 小细胞类如何对行为和感知回路做出贡献。章鱼细胞在所有的 哺乳动物物种,并且众所周知通过以下方式以亚毫秒精度编码时间输入: 初级感觉输入沿着其大而广泛的树突的整合。我们建议开展一项多- 实验室,章鱼细胞的分子和生物物理特性的综合分析,并跟踪这些单一的 细胞计算沿着听觉通路进行转换,以促进动物最终的听觉感知 因此行为也是如此。使用小鼠作为模型系统,我们将应用新的测序方法, 高分辨率脑成像和单细胞重建,以创建一个全面的布线图, 章鱼细胞及其听觉输入。通过产生选择性接触章鱼细胞的小鼠品系,我们将 是研究章鱼细胞体外和体内生理学的理想场所,因此可以 实验和计算模型的时序信息是如何编码在单细胞水平。最后我们 将研究如何通过记录大量的 中脑、丘脑和皮质的神经元,然后评估时间编码的功能相关性 for auditory听觉behavior行为.通过利用分子、生物物理、电生理、行为和计算 这种模型细胞类型的研究方法,这些研究将使我们能够提取的一般原则, 单细胞计算及其对系统级电路功能的影响,具有广泛的影响, 理解平行的信息流是如何被整合以产生感官知觉的。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Nace L Golding其他文献

Nace L Golding的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Nace L Golding', 18)}}的其他基金

Single-Cell Computation in Auditory Brainstem and its Impact on Cortical Coding and Behavior
听觉脑干中的单细胞计算及其对皮质编码和行为的影响
  • 批准号:
    10795699
  • 财政年份:
    2020
  • 资助金额:
    $ 10.06万
  • 项目类别:
Discovery of functional cell types in the inferior colliculus with combined molecular-genetic and electrophysiological approaches
结合分子遗传学和电生理学方法发现下丘功能细胞类型
  • 批准号:
    9300564
  • 财政年份:
    2017
  • 资助金额:
    $ 10.06万
  • 项目类别:
Synergistic in vivo and in vitro approaches in the MSO
MSO 中的体内和体外协同方法
  • 批准号:
    8032251
  • 财政年份:
    2011
  • 资助金额:
    $ 10.06万
  • 项目类别:
Synergistic in vivo and in vitro approaches in the MSO
MSO 中的体内和体外协同方法
  • 批准号:
    8212018
  • 财政年份:
    2011
  • 资助金额:
    $ 10.06万
  • 项目类别:
Pre-Doctoral Training in Interdisciplinary Neuroscience
跨学科神经科学博士前培训
  • 批准号:
    10163823
  • 财政年份:
    2004
  • 资助金额:
    $ 10.06万
  • 项目类别:
PRE-DOCTORAL TRAINING IN INTERDISCIPLINARY NEUROSCIENCE
跨学科神经科学博士前培训
  • 批准号:
    10606255
  • 财政年份:
    2004
  • 资助金额:
    $ 10.06万
  • 项目类别:
Dendritic Integration and Synaptic Plasticity in the MSO
MSO 中的树突整合和突触可塑性
  • 批准号:
    10316175
  • 财政年份:
    2004
  • 资助金额:
    $ 10.06万
  • 项目类别:
Dendritic integration and synaptic plasticity in the MSO
MSO 中的树突整合和突触可塑性
  • 批准号:
    8516491
  • 财政年份:
    2004
  • 资助金额:
    $ 10.06万
  • 项目类别:
Dendritic integration and synaptic plasticity in the MSO
MSO 中的树突整合和突触可塑性
  • 批准号:
    8387949
  • 财政年份:
    2004
  • 资助金额:
    $ 10.06万
  • 项目类别:
Pre-Doctoral Training in Interdisciplinary Neuroscience
跨学科神经科学博士前培训
  • 批准号:
    10441322
  • 财政年份:
    2004
  • 资助金额:
    $ 10.06万
  • 项目类别:

相似海外基金

The earliest exploration of land by animals: from trace fossils to numerical analyses
动物对陆地的最早探索:从痕迹化石到数值分析
  • 批准号:
    EP/Z000920/1
  • 财政年份:
    2025
  • 资助金额:
    $ 10.06万
  • 项目类别:
    Fellowship
Animals and geopolitics in South Asian borderlands
南亚边境地区的动物和地缘政治
  • 批准号:
    FT230100276
  • 财政年份:
    2024
  • 资助金额:
    $ 10.06万
  • 项目类别:
    ARC Future Fellowships
The function of the RNA methylome in animals
RNA甲基化组在动物中的功能
  • 批准号:
    MR/X024261/1
  • 财政年份:
    2024
  • 资助金额:
    $ 10.06万
  • 项目类别:
    Fellowship
Ecological and phylogenomic insights into infectious diseases in animals
对动物传染病的生态学和系统发育学见解
  • 批准号:
    DE240100388
  • 财政年份:
    2024
  • 资助金额:
    $ 10.06万
  • 项目类别:
    Discovery Early Career Researcher Award
Zootropolis: Multi-species archaeological, ecological and historical approaches to animals in Medieval urban Scotland
Zootropolis:苏格兰中世纪城市动物的多物种考古、生态和历史方法
  • 批准号:
    2889694
  • 财政年份:
    2023
  • 资助金额:
    $ 10.06万
  • 项目类别:
    Studentship
Using novel modelling approaches to investigate the evolution of symmetry in early animals.
使用新颖的建模方法来研究早期动物的对称性进化。
  • 批准号:
    2842926
  • 财政年份:
    2023
  • 资助金额:
    $ 10.06万
  • 项目类别:
    Studentship
Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research
研究人类晚期胎儿肺组织和 3D 体外类器官在肺发育研究中替代和减少动物
  • 批准号:
    NC/X001644/1
  • 财政年份:
    2023
  • 资助金额:
    $ 10.06万
  • 项目类别:
    Training Grant
RUI: Unilateral Lasing in Underwater Animals
RUI:水下动物的单侧激光攻击
  • 批准号:
    2337595
  • 财政年份:
    2023
  • 资助金额:
    $ 10.06万
  • 项目类别:
    Continuing Grant
RUI:OSIB:The effects of high disease risk on uninfected animals
RUI:OSIB:高疾病风险对未感染动物的影响
  • 批准号:
    2232190
  • 财政年份:
    2023
  • 资助金额:
    $ 10.06万
  • 项目类别:
    Continuing Grant
A method for identifying taxonomy of plants and animals in metagenomic samples
一种识别宏基因组样本中植物和动物分类的方法
  • 批准号:
    23K17514
  • 财政年份:
    2023
  • 资助金额:
    $ 10.06万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了