Single-cell computation in auditory brainstem and its impact on cortical coding and behavior
听觉脑干中的单细胞计算及其对皮质编码和行为的影响
基本信息
- 批准号:10455326
- 负责人:
- 金额:$ 10.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AnatomyAnimalsAuditoryAuditory PerceptionAuditory areaAuditory systemAxonBehaviorBehavioralBindingBiological ModelsBiophysicsBrainBrain StemBrain imagingCell physiologyCellsCochleaCochlear nucleusCodeComplexComputer ModelsComputing MethodologiesDataDecision MakingDendritesDetectionDiseaseEarElectron MicroscopyElectrophysiology (science)ElementsExperimental ModelsFrequenciesGene Expression ProfilingGoalsHeadHearingImageIn VitroIndividualInferior ColliculusLearningLinkMethodsMidbrain structureModelingMolecularMolecular AnalysisMorphologyMouse StrainsMusNeuronsOctopusOutputPatternPerceptionPerformancePhysiologicalPhysiologyPlayPopulationPositioning AttributeProcessPropertyPsychometricsResolutionRoleSensoryShapesSpeechStimulusStreamStudy modelsSynapsesSystemTestingThalamic structureTimeTrainingTranslatingTravelWhole-Cell RecordingsWorkauditory pathwayauditory thalamusawakebasebiophysical analysisbrain cellcell typeconfocal imagingexperimental studyin vivoinsightmillisecondmultidisciplinarynervous system disorderneuronal circuitrynovel strategiesoptogeneticsparallel processingpatch sequencingpredictive modelingreconstructionresponsesensory inputsensory mechanismsensory systemsoundspatiotemporalspiral ganglionsuccesstooltranscriptome sequencingtwo-photonvoltage
项目摘要
Project Abstract
Understanding how neuronal computations build up a perception of the external world is fundamental to our
understanding of how the brain works. This is particularly relevant to sensory systems, where heterogenous
inputs representing distinct sensory features must be re-assembled to generate a perception. How individual
neurons in early stages of sensory circuits process parallel inputs, and how these circuit elements later contribute
to cortical computations that bind the inputs together is completely unknown. Studies have demonstrated that
the timing, position and strength of a given input along the dendrite of a given neuron is a critical strategy used
by the brain to encode sensory features. However, how such dendritic integrations of inputs in single neurons
contribute to an animal's overall perception is not understood.
To re-assemble diverse features from the same initial stimulus, the brain needs to determine which features
occurred at the same time. Currently, little is known about how or where this timing information might be encoded.
The auditory system offers an ideal system to tackle this question based on its tractability to interdisciplinary
methods and its known ability to encode even miniscule differences in timing. Specifically, we will take advantage
of a unique cell type in the auditory cochlear nucleus, called octopus cells, as a model to investigate the question
of how small cell classes contribute to behavioral and perceptual circuits. Octopus cells are prominent in all
mammalian species and are well known to encode temporal inputs with submillisecond precision through
integration of primary sensory inputs along their large and extensive dendrites. We propose to carry out a multi-
lab, integrated analysis of the molecular and biophysical properties of octopus cells and to track how these single
cell computations are transformed along the auditory pathway to contribute to an animal's final auditory percept
and hence behavior. Using the mouse as a model system, we will apply new sequencing methods together with
high resolution brain imaging and single cell reconstructions to create a comprehensive wiring diagram of
octopus cells and their auditory inputs. By generating mouse strains for selective access to octopus cells, we will
be ideally positioned to investigate the in vitro and in vivo physiology of octopus cells and therefore bridge
experimental and computational models for how timing information is encoded at the single cell level. Lastly, we
will study how timing information propagates to higher auditory centers by recording from large populations of
neurons in the midbrain, thalamus, and cortex and then assessing the functional relevance of temporal coding
for auditory behavior. By leveraging molecular, biophysical, electrophysiological, behavioral, and computational
approaches toward the study of this model cell type, these studies will allow us to extract general principles of
single cell computations and their effects on systems-level circuit function, with broad implications for
understanding how parallel streams of information are integrated to generate sensory perception.
项目摘要
项目成果
期刊论文数量(0)
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{{ truncateString('Nace L Golding', 18)}}的其他基金
Single-Cell Computation in Auditory Brainstem and its Impact on Cortical Coding and Behavior
听觉脑干中的单细胞计算及其对皮质编码和行为的影响
- 批准号:
10795699 - 财政年份:2020
- 资助金额:
$ 10.06万 - 项目类别:
Discovery of functional cell types in the inferior colliculus with combined molecular-genetic and electrophysiological approaches
结合分子遗传学和电生理学方法发现下丘功能细胞类型
- 批准号:
9300564 - 财政年份:2017
- 资助金额:
$ 10.06万 - 项目类别:
Synergistic in vivo and in vitro approaches in the MSO
MSO 中的体内和体外协同方法
- 批准号:
8032251 - 财政年份:2011
- 资助金额:
$ 10.06万 - 项目类别:
Synergistic in vivo and in vitro approaches in the MSO
MSO 中的体内和体外协同方法
- 批准号:
8212018 - 财政年份:2011
- 资助金额:
$ 10.06万 - 项目类别:
Pre-Doctoral Training in Interdisciplinary Neuroscience
跨学科神经科学博士前培训
- 批准号:
10163823 - 财政年份:2004
- 资助金额:
$ 10.06万 - 项目类别:
PRE-DOCTORAL TRAINING IN INTERDISCIPLINARY NEUROSCIENCE
跨学科神经科学博士前培训
- 批准号:
10606255 - 财政年份:2004
- 资助金额:
$ 10.06万 - 项目类别:
Dendritic Integration and Synaptic Plasticity in the MSO
MSO 中的树突整合和突触可塑性
- 批准号:
10316175 - 财政年份:2004
- 资助金额:
$ 10.06万 - 项目类别:
Dendritic integration and synaptic plasticity in the MSO
MSO 中的树突整合和突触可塑性
- 批准号:
8516491 - 财政年份:2004
- 资助金额:
$ 10.06万 - 项目类别:
Dendritic integration and synaptic plasticity in the MSO
MSO 中的树突整合和突触可塑性
- 批准号:
8387949 - 财政年份:2004
- 资助金额:
$ 10.06万 - 项目类别:
Pre-Doctoral Training in Interdisciplinary Neuroscience
跨学科神经科学博士前培训
- 批准号:
10441322 - 财政年份:2004
- 资助金额:
$ 10.06万 - 项目类别:
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