Dendritic Integration and Synaptic Plasticity in the MSO

MSO 中的树突整合和突触可塑性

基本信息

  • 批准号:
    10316175
  • 负责人:
  • 金额:
    $ 43.03万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2004
  • 资助国家:
    美国
  • 起止时间:
    2004-07-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Project Summary Humans and other mammals use the temporal fine structure in sounds to identify and help localize auditory objects in three-dimensional space. The broad goal of this research is both to understand how sound localization cues are processed in the brain as well as to understand how neurons in the underlying circuitry acquire the appropriate biophysical properties during development. This proposal focuses on the medial superior olive (MSO), the first and critical stage for processing interaural time differences (ITDs) from the two ears, cues that are used for horizontal sound localization as well as for understanding speech patterns in noisy environments. ITDs are computed in the MSO via the process of coincidence detection, in which the simultaneous arrival of excitatory inputs from the two ears is detected and conveyed through action potential firing with a time resolution of a few tens of microseconds. The neurons of the MSO have historically been assumed to be functionally and morphologically homogeneous. However, our preliminary data refutes this simplistic view of the MSO: we hypothesize instead that variation in dendritic morphology and electrical properties critically shapes the location of spatial receptive fields, and that these differences are in part influenced after hearing onset by the level and pattern of neural activity. We will address these questions by combining paired dendritic and somatic patch recordings, compartmental modeling, patterned LED illumination of light-sensitive channel blockers, and hearing manipulations. Aim 1 will address the functional significance of the newly discovered tonotopic diversity in electophysiological properties of MSO neurons both in vitro using patch- clamp recordings. Aim 2 will extend these analyses to understand how the functional diversity in MSO neurons is conferred by differences in the expression levels and properties of voltage-gated channels in the axon initial segment. Aim 3 will explore how the diversity of dendritic structure itself shapes the temporal requirements for optimal detection of binaural coincidence. The information from these experiments will increase our understanding of the mechanisms underlying spatial hearing in mammals, as well as the developmental processes that control the formation of a critical circuit component in the MSO. As binaural hearing is important for speech perception and language acquisition in children, a mechanistic understanding of binaural circuit function and development may ultimately inform clinical strategies for addressing hearing impairments.
项目摘要 人类和其他哺乳动物使用声音中的时间精细结构来识别和帮助 在三维空间中定位听觉对象。这项研究的主要目标是 了解声音定位线索是如何在大脑中处理的,以及了解如何 在发育过程中,底层回路中的神经元获得适当的生物物理特性。 该建议侧重于内侧上级橄榄(MSO),这是加工的第一个关键阶段 来自两耳的耳间时间差(ITD),用于水平声音定位的线索 以及用于理解噪声环境中的语音模式。ITD在MSO中通过 重合检测的过程,其中来自两个兴奋性输入的同时到达 通过动作电位放电检测和传送耳朵,时间分辨率为几十秒。 微秒。 MSO的神经元在历史上一直被认为是功能和形态 同质的然而,我们的初步数据驳斥了这种简单的MSO观点:我们假设 相反,枝晶形态和电性能变化决定性地形成了 空间感受野,并且这些差异在听力开始后部分受到水平的影响。 和神经活动模式我们将通过结合成对的树突和体细胞来解决这些问题。 斑片记录,房室模型,光敏通道的图案化LED照明 阻断剂和听力操纵。目标1将讨论新的 发现了在体外使用贴片,MSO神经元的电生理特性的tonotopic多样性, 钳夹记录。目标2将扩展这些分析,以了解MSO中的功能多样性 神经元中的电压门控通道的表达水平和性质的差异赋予了神经元 轴突起始段。目标3将探讨树突状结构本身的多样性如何塑造 双耳重合的最佳检测的时间要求。 从这些实验中获得的信息将增加我们对机制的理解 哺乳动物潜在的空间听觉,以及控制空间听觉的发育过程。 在MSO中形成关键电路元件。由于双耳听力对说话很重要, 儿童的感知和语言习得,对双耳电路功能的机械理解 和发展可能最终为解决听力障碍的临床策略提供信息。

项目成果

期刊论文数量(15)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
In vivo coincidence detection in mammalian sound localization generates phase delays.
  • DOI:
    10.1038/nn.3948
  • 发表时间:
    2015-03
  • 期刊:
  • 影响因子:
    25
  • 作者:
    Franken, Tom P.;Roberts, Michael T.;Wei, Liting;Golding, Nace L.;Joris, Philip X.
  • 通讯作者:
    Joris, Philip X.
Glycinergic Inhibitory Plasticity in Binaural Neurons Is Cumulative and Gated by Developmental Changes in Action Potential Backpropagation.
双耳神经元中的甘氨酸能抑制可塑性是累积的,并由动作电位反向传播的发育变化控制。
  • DOI:
    10.1016/j.neuron.2018.03.001
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    16.2
  • 作者:
    Winters,BradleyD;Golding,NaceL
  • 通讯作者:
    Golding,NaceL
An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.
Amplitude Normalization of Dendritic EPSPs at the Soma of Binaural Coincidence Detector Neurons of the Medial Superior Olive.
内侧上橄榄双耳符合检测器神经元体树突 EPSP 的振幅标准化。
Perisomatic voltage-gated sodium channels actively maintain linear synaptic integration in principal neurons of the medial superior olive.
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Nace L Golding其他文献

Nace L Golding的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Nace L Golding', 18)}}的其他基金

Single-cell computation in auditory brainstem and its impact on cortical coding and behavior
听觉脑干中的单细胞计算及其对皮质编码和行为的影响
  • 批准号:
    10455326
  • 财政年份:
    2020
  • 资助金额:
    $ 43.03万
  • 项目类别:
Single-Cell Computation in Auditory Brainstem and its Impact on Cortical Coding and Behavior
听觉脑干中的单细胞计算及其对皮质编码和行为的影响
  • 批准号:
    10795699
  • 财政年份:
    2020
  • 资助金额:
    $ 43.03万
  • 项目类别:
Discovery of functional cell types in the inferior colliculus with combined molecular-genetic and electrophysiological approaches
结合分子遗传学和电生理学方法发现下丘功能细胞类型
  • 批准号:
    9300564
  • 财政年份:
    2017
  • 资助金额:
    $ 43.03万
  • 项目类别:
Synergistic in vivo and in vitro approaches in the MSO
MSO 中的体内和体外协同方法
  • 批准号:
    8032251
  • 财政年份:
    2011
  • 资助金额:
    $ 43.03万
  • 项目类别:
Synergistic in vivo and in vitro approaches in the MSO
MSO 中的体内和体外协同方法
  • 批准号:
    8212018
  • 财政年份:
    2011
  • 资助金额:
    $ 43.03万
  • 项目类别:
Pre-Doctoral Training in Interdisciplinary Neuroscience
跨学科神经科学博士前培训
  • 批准号:
    10163823
  • 财政年份:
    2004
  • 资助金额:
    $ 43.03万
  • 项目类别:
PRE-DOCTORAL TRAINING IN INTERDISCIPLINARY NEUROSCIENCE
跨学科神经科学博士前培训
  • 批准号:
    10606255
  • 财政年份:
    2004
  • 资助金额:
    $ 43.03万
  • 项目类别:
Dendritic integration and synaptic plasticity in the MSO
MSO 中的树突整合和突触可塑性
  • 批准号:
    8516491
  • 财政年份:
    2004
  • 资助金额:
    $ 43.03万
  • 项目类别:
Dendritic integration and synaptic plasticity in the MSO
MSO 中的树突整合和突触可塑性
  • 批准号:
    8387949
  • 财政年份:
    2004
  • 资助金额:
    $ 43.03万
  • 项目类别:
Pre-Doctoral Training in Interdisciplinary Neuroscience
跨学科神经科学博士前培训
  • 批准号:
    10441322
  • 财政年份:
    2004
  • 资助金额:
    $ 43.03万
  • 项目类别:

相似海外基金

Targeted ablation of cerebral atherosclerosis using supramolecular self-assembly
利用超分子自组装靶向消融脑动脉粥样硬化
  • 批准号:
    24K21101
  • 财政年份:
    2024
  • 资助金额:
    $ 43.03万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
心房細動に対するPulsed Field Ablationの組織創傷治癒過程を明らかにする網羅的研究
阐明房颤脉冲场消融组织伤口愈合过程的综合研究
  • 批准号:
    24K11201
  • 财政年份:
    2024
  • 资助金额:
    $ 43.03万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
遅延造影心臓MRIによる心房細動Ablation冷却効果の比較:28 vs. 31 mm Cryoballoon
使用延迟对比增强心脏 MRI 比较房颤消融冷却效果:28 毫米与 31 毫米 Cryoballoon
  • 批准号:
    24K11281
  • 财政年份:
    2024
  • 资助金额:
    $ 43.03万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
CAREER: Heat Penetration Depth and Direction Control with Closed-Loop Device for Precision Ablation
职业:利用闭环装置控制热穿透深度和方向,实现精确烧蚀
  • 批准号:
    2338890
  • 财政年份:
    2024
  • 资助金额:
    $ 43.03万
  • 项目类别:
    Continuing Grant
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
  • 批准号:
    2334777
  • 财政年份:
    2024
  • 资助金额:
    $ 43.03万
  • 项目类别:
    Continuing Grant
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
  • 批准号:
    2334775
  • 财政年份:
    2024
  • 资助金额:
    $ 43.03万
  • 项目类别:
    Continuing Grant
InSPACE-VT_Development and Validation of Virtual Pace Mapping to Guide Catheter Ablation of Ventricular Tachycardia
InSPACE-VT_虚拟起搏测绘的开发和验证以指导室性心动过速导管消融
  • 批准号:
    EP/Z001145/1
  • 财政年份:
    2024
  • 资助金额:
    $ 43.03万
  • 项目类别:
    Fellowship
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
  • 批准号:
    2334776
  • 财政年份:
    2024
  • 资助金额:
    $ 43.03万
  • 项目类别:
    Continuing Grant
Cryo laser-ablation system (157+193nm) with 'triple-quad' plasma mass spectrometer, Cryo-LA-ICPMS/MS
带有“三重四极杆”等离子体质谱仪、Cryo-LA-ICPMS/MS 的冷冻激光烧蚀系统 (157 193nm)
  • 批准号:
    515081333
  • 财政年份:
    2023
  • 资助金额:
    $ 43.03万
  • 项目类别:
    Major Research Instrumentation
MRI: Acquisition of a Laser Ablation - Inductively Coupled Plasma - Triple Quadrupole - Mass Spectrometer (LA-ICP-QQQ-MS) System For Research and Education
MRI:获取用于研究和教育的激光烧蚀 - 电感耦合等离子体 - 三重四极杆 - 质谱仪 (LA-ICP-MS/MS) 系统
  • 批准号:
    2320040
  • 财政年份:
    2023
  • 资助金额:
    $ 43.03万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了