Quantifying Multi-Scale Architecture of Cardiac Tissues
量化心脏组织的多尺度结构
基本信息
- 批准号:10454132
- 负责人:
- 金额:$ 7.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-20 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressArchitectureBiologicalBiological AssayBiomechanicsCardiacCardiac MyocytesCardiac developmentCellsCodeComputer softwareDataData AnalysesDiseaseEffectivenessElectrophysiology (science)EngineeringExperimental ModelsGene ExpressionGenerationsGenesGeometryGoalsHealthHeartHeart DiseasesHeterogeneityImageImage AnalysisImplantLawsLengthMeasuresMechanicsMethodsModelingMuscleMuscle functionMyocardiumMyofibrilsNatureOrganOutcomePathologicPathologyPatientsPharmacologyProductionPumpSamplingSarcomeresStressStriated MusclesStructureStructure-Activity RelationshipTechniquesTimeTissue EngineeringTissuesWorkautomated image analysiscardiac tissue engineeringheart functioninduced pluripotent stem cellinduced pluripotent stem cell derived cardiomyocytesresponsesecond harmonicsingle-cell RNA sequencingstem cellstool
项目摘要
Project Summary/Abstract
Biological tissues have intricate multi-scale organizations integrating multiple component, and this architec-
ture is often changed in pathology. Moreover, it is suspected that altered architecture contributes to loss
of efficient functionalities in tissues and organs. For instance, the heart muscle's myofibril organization is
disturbed during many heart diseases, and structural changes are known to impact both contractility and
electrophysiology. However, the mechanisms by which architectural changes at a specific spatial scales
impact muscle functionality, such as contractility, are not well understood. One of the big challenges in dis-
covering these mechanisms is the adaptability of living muscle tissue. Indeed, changing the architecture at
some length scales triggers a downstream effect that is reflected in a change to the expression levels of a
variety of genes some of which contribute to the contraction function. Thus the mechanobiology of cardiac
tissue remains, in many aspects, a mystery, which is to be address in this project by discovering, through
experimental and modeling work, some of the biomechanical laws that control the relationship between or-
ganization and contractility. In Aim 1, we will expand the understanding of the mechanical consequences
of the biological changes triggered in some tissues by pursuing exploring if one of the mechanisms that is
important in determining the structure-function relationship in striated muscle is the registration of sarcom-
eres. In Aim 2, we will optimize existing analysis software and codes developed in Aim 1 to understand the
heterogenous maturation nature of stem-cell derived cardiac tissues. New image analysis methods will be
combined with structure-function model to elucidate the mechanisms behind cardiac development.
项目摘要/摘要
生物组织具有复杂的多尺度组织,集成了多种成分,而这种体系结构--
在病理学上,真理往往是变化的。此外,人们怀疑更改的架构也会造成损失
在组织和器官中有效的fi功能。例如,心肌的肌fi纤毛肌组织是
在许多心脏病期间受到干扰,结构变化已知会影响收缩能力和
电生理学。然而,建筑在特定的fic空间尺度上变化的机制
冲击性肌肉的功能,如收缩能力,还没有被很好地理解。分发中的一大挑战是-
覆盖这些机制的是活的肌肉组织的适应性。事实上,在以下方面更改架构
一些长度尺度触发下游效应,这种下游效应在fl基因表达水平的改变中被反映出来
多种基因,其中一些对收缩功能有贡献。因此,心脏的机械生物学
在许多方面,组织仍然是一个谜,这将在这个项目中通过发现
实验和建模工作,一些生物力学定律控制之间的关系或-
组织性和可伸缩性。在目标1中,我们将扩展对机械后果的理解
通过探索在某些组织中触发的生物学变化的机制之一是否是
在确定横纹肌的结构-功能关系中,重要的是肌瘤的注册。
艾瑞斯。在目标2中,我们将优化目标1中开发的现有分析软件和代码,以了解
干细胞来源的心脏组织的异质性成熟特性。新的图像分析方法将是
结合结构-功能模型阐明心脏发育的机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Anna Grosberg其他文献
Anna Grosberg的其他文献
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{{ truncateString('Anna Grosberg', 18)}}的其他基金
Functional and mechanistic analysis of FSHD myocytes
FSHD 肌细胞的功能和机制分析
- 批准号:
10287407 - 财政年份:2021
- 资助金额:
$ 7.09万 - 项目类别:
Quantifying Multi-Scale Architecture of Cardiac Tissues
量化心脏组织的多尺度结构
- 批准号:
10217763 - 财政年份:2021
- 资助金额:
$ 7.09万 - 项目类别:
Cardiac Functional and Structural Implications of Lamin A/C Mutations
Lamin A/C 突变对心脏功能和结构的影响
- 批准号:
9137705 - 财政年份:2015
- 资助金额:
$ 7.09万 - 项目类别:
Cardiac Functional and Structural Implications of Lamin A/C Mutations
Lamin A/C 突变对心脏功能和结构的影响
- 批准号:
9266679 - 财政年份:2015
- 资助金额:
$ 7.09万 - 项目类别:
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